anti-Holocytochrome C Synthase (HCCS) Anticorps

The protein encoded by HCCS is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. De plus, nous expédions Holocytochrome C Synthase Kits (20) et Holocytochrome C Synthase Protéines (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
HCCS 3052 P53701
HCCS 317444  
HCCS 15159 P53702
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Top anti-Holocytochrome C Synthase Anticorps sur anticorps-enligne.fr

Showing 10 out of 101 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Chien Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IC, IF, IP, IHC, WB Immunofluorescent analysis of HCCS staining in Raw264.7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of HCCS staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué IF, IHC, ELISA, WB Western blot analysis of extracts from HeLa/HepG2/COLO cells, using Cytochrome c-type Heme Lyase Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using Cytochrome c-type Heme Lyase Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB Western blot analysis of extracts from rat kidney, using Cytochrome c-type Heme Lyase Antibody. Western blot analysis of extracts from HeLa cells using Cytochrome c-type Heme Lyase antibody. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded colon carcinoma reacted with HCCS / CCHL Antibody (Center) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of HCCS / CCHL Antibody (Center) in mouse heart tissue lysates (35ug/lane). HCCS (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human Hela Cells; Lane2: Rat Placenta Tissue. Figure. Western Blot; Sample: Recombinant HCCS, Human. 100 μg 13 to 16 Days
$350.00
Détails
Humain Lapin Inconjugué ELISA, IF, IHC, WB 100 μL Disponible
$363.46
Détails
Chien Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails
Hamster Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails

anti-Holocytochrome C Synthase Anticorps mieux référencés

  1. Human Polyclonal HCCS Primary Antibody pour ICC, IF - ABIN4316664 : Thinon, Serwa, Broncel, Brannigan, Brassat, Wright, Heal, Wilkinson, Mann, Tate: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. dans Nature communications 2014 (PubMed)

Plus d’anticorps contre Holocytochrome C Synthase partenaires d’interaction

Human Holocytochrome C Synthase (HCCS) interaction partners

  1. Data suggest that although HCCS mediates heme attachment to N-terminal cysteine in heme-attachment site (CXXXH) of cytochrome C variants, up to 50% of cytochrome C produced is modified in an oxygen-dependent manner, resulting in a mixed population of cytochrome c. [HCCS = holocytochrome c synthase]

  2. Bacterial cyt c biogenesis pathways (Systems I and II) appear to recognize simply the CXXCH motif, not requiring alpha helix-1. Results here explain mechanistically how HCCS (System III) requires an extended region adjacent to CXXCH for maturation.

  3. cysteines and histidine of the heme attachment site, Cys-XX-Cys-His play a key role in mitochondrial holocytochrome c synthase

  4. These data indicate that heme contacts mediated by residues within these domains modulate the dynamics of heme binding and contribute to the stability of the HCCS-heme-cytochrome c steady state ternary complex.

  5. Identification of a deletion in two patients, including HCCS, leads to the diagnosis of microphthalmia with linear skin defects syndrome

  6. Spectroscopic analyses of HCCS alone and complexes of HCCS with site-directed variants of cytochrome c revealed the fundamental steps of heme attachment and maturation.

  7. Through the study of genetically engineered mice, the loss of HCCS is demonstrated to cause the male lethality of microphthalmia with linear skin defects (MLS) syndrome.

  8. mutant proteins (R217C and Delta 197-268) were unable to complement a Saccharomyces cerevisiae mutant deficient for the HCCS orthologue Cyc3p, in contrast to wild-type HCCS

  9. Missense mutation p.E159K of HCCS, leading to loss-of-function of encoded holocytochrome c-type synthase, in female with microphthalmia of both eyes and bilateral sclerocornea may suggest HCCS as candidate for severe ocular manifestations.

Mouse (Murine) Holocytochrome C Synthase (HCCS) interaction partners

  1. Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice

Holocytochrome C Synthase (HCCS) profil antigène

Profil protéine

The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with HCCS

  • holocytochrome c synthase b (hccsb) anticorps
  • holocytochrome c synthase (hccs) anticorps
  • cytochrome c heme-lyase (cchl) anticorps
  • holocytochrome c synthase (HCCS) anticorps
  • holocytochrome c synthase (Hccs) anticorps
  • cytochrome c-type heme lyase (LOC100356413) anticorps
  • holocytochrome c synthetase (Hccs) anticorps
  • CCHL anticorps
  • DDBDRAFT_0217711 anticorps
  • DDBDRAFT_0266707 anticorps
  • DDB_0217711 anticorps
  • DDB_0266707 anticorps
  • hccsb anticorps
  • id:ibd1278 anticorps
  • MCOPS7 anticorps
  • RGD1563855 anticorps
  • wu:fb18h01 anticorps
  • wu:fc64e12 anticorps
  • wu:fi43e01 anticorps

Protein level used designations for HCCS

cytochrome c-type heme lyase , holocytochrome c synthetase b , holocytochrome c synthase (cytochrome c heme-lyase) , holocytochrome c synthase , cytochrome c heme-lyase , holocytochrome c-type synthase , holocytochrome c synthetase , CCHL

GENE ID SPECIES
58016 Danio rerio
448226 Xenopus (Silurana) tropicalis
8620147 Dictyostelium discoideum AX4
3052 Homo sapiens
317444 Rattus norvegicus
506250 Bos taurus
424482 Gallus gallus
480834 Canis lupus familiaris
100356413 Oryctolagus cuniculus
15159 Mus musculus
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