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HOXB2 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain.
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Human Polyclonal HOXB2 Primary Antibody pour WB - ABIN1881427
Acampora, DEsposito, Faiella, Pannese, Migliaccio, Morelli, Stornaiuolo, Nigro, Simeone, Boncinelli: The human HOX gene family. dans Nucleic acids research 1990
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HOXB2 and HOXB3 (Montrer HOXB3 Anticorps) act as tumor suppressors in acute myeloid leukemia (Montrer BCL11A Anticorps) patients carrying the FLT3 (Montrer FLT3 Anticorps) protein mutations.
Increased expression of HOXB2 protein is associated with HPV infection and cervical cancer progression.
HOXB2 acts as a negative tumor growth regulator, decreasing proliferation in mammary adenocarcinoma tumors.
hoxb2 and hoxb4 (Montrer HOXB4 Anticorps) expression is related to erythroid hematopoiesis, and hoxb4 (Montrer HOXB4 Anticorps) has greater relevance to erythroid hematopoiesis as compared with hoxb2.
Downregulation of HoxB2, HoxB4 (Montrer HOXB4 Anticorps) and Alx4 (Montrer ALX4 Anticorps) expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation.
Data show that inducible Hox (Montrer MSH2 Anticorps) genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox (Montrer MSH2 Anticorps) genes.
Hoxb2 is a direct target for regulation by PLZF (Montrer ZBTB16 Anticorps) in the developing CNS and suggest that deregulation of Hox (Montrer MSH2 Anticorps) gene expression may contribute to APL (Montrer FASL Anticorps) pathogenesis.
HOXB2 up-regulated lesions to have much higher HOXB2 expression than the corresponding normal tissue.
These results establish a role for Hox (Montrer MSH2 Anticorps) factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit.
Hoxb2 antagonizes Hoxa2 (Montrer HOXA2 Anticorps) during rostral hindbrain oligodendrogenesis.
results describe the functional requirements in hindbrain neuronal patterning that follow the establishment of the genetic regulatory hierarchy between Hoxa1 (Montrer HOXA1 Anticorps), Hoxb1 (Montrer HOXB1 Anticorps) and Hoxb2
Interaction of HoxB2 with mutant SOD1 (Montrer SOD1 Anticorps) occurs in motor neurons of G93A mutant SOD1 (Montrer SOD1 Anticorps) transgenic mice and suggest that this interaction may modulate the neurotoxicity of mutant SOD1 (Montrer SOD1 Anticorps).
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.
, homeobox protein Hoxb-2
, homeobox protein Hox-B2a
, homeobox gene B-2
, transcription factor Hoxb2
, K8 home protein
, homeo box 2H
, homeo box B2
, homeobox protein Hox-2.8
, homeobox protein Hox-2H
, homeobox protein Hox-B2
, Hoxb2-like epididymal protein