anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) Anticorps

HCN4 encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. De plus, nous expédions HCN4 Kits (14) et HCN4 Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
HCN4 10021 Q9Y3Q4
HCN4 59266 Q9JKA7
HCN4 330953  
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Top anti-HCN4 Anticorps sur anticorps-enligne.fr

Showing 10 out of 90 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Mammifères Souris Inconjugué ISt, IHC, WB   5 mL Connectez-vous pour afficher 2 to 6 Days
$366.67
Détails
Humain Souris HRP AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$422.40
Détails
Humain Souris FITC AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$426.80
Détails
Humain Souris Alkaline Phosphatase (AP) AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$429.00
Détails
Humain Souris Biotin AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$431.20
Détails
Humain Souris PE AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$432.30
Détails
Humain Souris Streptavidin AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$433.40
Détails
Humain Souris APC AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$434.50
Détails
Humain Souris PerCP AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$434.50
Détails
Humain Souris Atto 488 AA, ICC, IF, IHC, WB Immunohistochemistry analysis using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human T-HEK cell lysate showing detection of HCN4 protein using Mouse Anti-HCN4 Monoclonal Antibody, Clone S114-10 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-HCN4 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$435.60
Détails

anti-HCN4 Anticorps mieux référencés

  1. Mammalian Monoclonal HCN4 Primary Antibody pour ISt, IHC - ABIN1304701 : Stradleigh, Ishida: Fixation strategies for retinal immunohistochemistry. dans Progress in retinal and eye research 2015 (PubMed)
    Show all 19 Pubmed References

  2. Human Polyclonal HCN4 Primary Antibody pour IF (p), IHC (p) - ABIN733043 : Li, Hong, Zhang, Zhou, Ji, Li, Hu, Li, Sun, Zhang, Xin, Yusufuaji, Xiong, Tang: Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation. dans Medical science monitor : international medical journal of experimental and clinical research 2014 (PubMed)

Plus d’anticorps contre HCN4 partenaires d’interaction

Human Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) interaction partners

  1. These findings indicate that HCN4(G811E) may not be a monogenic factor to cause the cardiac disorders.

  2. We here report on multiple families harboring HCN4 mutations, who show significant dilation of the aorta ascendens

  3. A novel splice site HCN4 gene mutation was identified in a large family with familial bradycardia.

  4. Sick sinus syndrome (SSS) with HCN4 mutations may form a distinct SSS subgroup characterized by early clinical manifestation after adolescence and frequent association with atrial fibrillation and left ventricular noncompaction.

  5. This study has identified 4 synonymous variants in the HCN4 gene and 3 SNPs in the CYP3A4 (Montrer CYP3A4 Anticorps) gene. None of the variants appear to have a major effect on the reduction of HR produced by ivabradine.

  6. HCN4 channel remodeling following exercise and subsequent sinus bradycardia in athletes is controlled by miR (Montrer MLXIP Anticorps)-423-5p.

  7. Our results indicate that HCN4 channel function is modulated by cav-3 (Montrer CAV3 Anticorps). LQTS-associated mutations of cav-3 (Montrer CAV3 Anticorps) differentially influence pacemaker current properties indicating a pathophysiological role in clinical manifestations.

  8. Identified in Brugada syndrome patient HCN4 mutation results in reduced channel function in HEK293 cells.

  9. S672R mutation results in a constitutive shift of the dynamic auto-inhibitory equilibrium toward inactive states of HCN4 and broadens the free-energy well of the apo (Montrer C9orf3 Anticorps)-form, enhancing the millisecond to microsecond dynamics of the holo-form at sites critical for gating cAMP binding.

  10. Our results confirm the genetic evidence for the involvement of the HCN4 mutations in the combined bradycardia-non compaction cardiomyopathy phenotype and illustrates that.

Rabbit Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) interaction partners

  1. HCN4-overexpressing mouse embryonic stem cell -derived cardiomyocytes produce rapid ectopic ventricular rhythms as a biological pacemaker.

  2. Ischemia-reperfusion is harmful to the sinoatrial node and reduces the expression of HCN4.

  3. SAP97 contributes to isoform specific organization of HCN channels within specific domains in the sinoatrial node of the rabbit.

  4. HCN protein expression in the rabbit pacemaker region, was investigated.

Mouse (Murine) Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) interaction partners

  1. This study demonstrated that HCN4 (Montrer HCN3 Anticorps) regulate the glutamate (Montrer GRIN1 Anticorps) release from presynaptic terminals that target excitatory, but not inhibitory spinal substantia gelatinosa interneurons.

  2. Data show that prostaglandin E2 receptor EP3 subtype (EP3 (Montrer PTGER3 Anticorps)) was expressed in the interstitial cells of Cajal (ICCs) of the bladder and activated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

  3. that hyperpolarization-activated cyclic nucleotide-gated cation channel 4 (HCN4) expression was significantly higher and HCN2 (Montrer HCN2 Anticorps) expression was significantly lower in fetal day 13 mice than in adults

  4. beating rate of hiPSC-CMs (Montrer Cd2ap Anticorps) co-cultured with aggregates of HCN4 (Montrer HCN3 Anticorps)-overexpressing mESC-CMs (Montrer Cd2ap Anticorps) was significantly higher than that of non-treated hiPSC-CMs (Montrer Cd2ap Anticorps) and that of hiPSC-CMs (Montrer Cd2ap Anticorps) co-cultured with aggregates of non-overexpressing mESC-CMs (Montrer Cd2ap Anticorps)

  5. study establishes the role of f-channels in cardiac automaticity and indicates that arrhythmia related to HCN loss-of-function may be managed by pharmacological or genetic inhibition of GIRK4 (Montrer KCNJ5 Anticorps) channels

  6. HCN1 (Montrer HCN1 Anticorps), HCN2 (Montrer HCN2 Anticorps), and HCN4 (Montrer HCN3 Anticorps) subunits may have distinct physiological roles in the developing hippocampus.

  7. Shox2 (Montrer SHOX2 Anticorps) regulates dorsal mesenchymal protrusion fate and development by controlling BMP signaling through the Smad (Montrer SMAD1 Anticorps)-dependent pathway to drive tissue growth and to induce Hcn4 (Montrer HCN3 Anticorps) expression

  8. HCN4 (Montrer HCN3 Anticorps) dynamically marks the first heart field and conduction system precursors.

  9. testosterone induced cardiomyogenesis, at least in part, by recruiting the AR receptor to the regulatory regions of the MEF2C (Montrer MEF2C Anticorps) and HCN4 (Montrer HCN3 Anticorps) genes.

  10. Data suggest that TRPM7 (Montrer TRPM7 Anticorps) influences diastolic membrane depolarization and automaticity in embryonic myocardium and sinoatrial node (SAN) indirectly via regulation of Hcn4 (Montrer HCN3 Anticorps) expression.

HCN4 profil antigène

Profil protéine

This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15.

Gene names and symbols associated with HCN4

  • hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4) anticorps
  • hyperpolarization activated cyclic nucleotide gated potassium channel 4 (hcn4) anticorps
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (Hcn4) anticorps
  • hyperpolarization-activated, cyclic nucleotide-gated K+ 4 (Hcn4) anticorps
  • Bcng3 anticorps
  • HAC4 anticorps
  • Hcn3 anticorps
  • SSS2 anticorps

Protein level used designations for HCN4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4 , hyperpolarization activated cyclic nucleotide-gated cation channel 4 , potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 , hyperpolarization-activated, cyclic nucleotide-gated K+ 4 , HAC-4 , hyperpolarization activated cation channel , hyperpolarization-activated cation channel 4 , BCNG-3 , brain cyclic nucleotide-gated channel 3 , hyperpolarization-activated, cyclic nucleotide-gated K+ 3

GENE ID SPECIES
100544822 Meleagris gallopavo
100560546 Anolis carolinensis
10021 Homo sapiens
59266 Rattus norvegicus
785689 Bos taurus
100009452 Oryctolagus cuniculus
330953 Mus musculus
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