anti-Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Anticorps

Human Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

1. AA can protect cardiomyocytes against hypoxia-induced apoptosis through regulating the miR (Montrer MLXIP Anticorps)-1290/HIF3A/HIF-1alpha (Montrer HIF1A Anticorps) axis, and miR (Montrer MLXIP Anticorps)-1290 may be a potential target in the prevention of myocardial ischemia-reperfusion injury

2. NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha (Montrer HIF1A Anticorps)/HIF2alpha (Montrer EPAS1 Anticorps), VEGF (Montrer VEGFA Anticorps)/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX (Montrer BAX Anticorps) and Bcl2 (Montrer BCL2 Anticorps).

3. HIF3A methylation was found in the association between the HIF3A rs3826795 polymorphism and alanine aminotransferase (Montrer ALT Anticorps) among obese children.

4. TIMP2 (Montrer TIMP2 Anticorps) suppression, in a hypoxic environment, was induced through a regulatory feedback circuit consisting of hypoxia-inducible factor (HIF) 1 alpha (Montrer HIF1A Anticorps), microRNA-210 (miR (Montrer MLXIP Anticorps)-210), and HIF-3alpha.

5. Results were discordant with those expected if HIF3A methylation has a causal effect on body mass index (BMI) & provided more evidence for causality in the reverse direction (i.e., an effect of BMI on HIF3A methylation); results also show a long-lasting intergenerational influence of maternal BMI on offspring methylation at this locus, which may confound associations between own adiposity & HIF3A methylation.

6. DNA methylation (Montrer HELLS Anticorps) in HIF3A shares moderate correlation between adipose tissue and blood, and both are associated with BMI. In contrast, methylation in FASN (Montrer FASN Anticorps) is poorly correlated across tissues, but the DNA methylation (Montrer HELLS Anticorps) in adipose tissue but not blood is highly associated with BMI

7. Reduced lifetimes of the donor were partially restored by coexpression of HIF-1alpha (Montrer HIF1A Anticorps) or Bcl-xL (Montrer BCL2L1 Anticorps), binding proteins of IPAS in the nucleus and mitochondria, respectively.

8. Results confirmed a positive association between BMI and HIF3A DNA promoter methylation in the blood. The tissue-specific results of HIF3A gene expression indicate that subcutaneous adipose tissue is the more functional tissue in which a low expression may adversely affect whole-body insulin (Montrer INS Anticorps) sensitivity.

9. Parkin (Montrer PARK2 Anticorps) is downregulated under hypoxia and that it interferes with HIF expression based on cellular oxygen tension.

10. This provides a compelling model for how hypoxia-induced miR (Montrer MLXIP Anticorps)-429 regulates the switch between HIF-1 (Montrer HIF1A Anticorps) adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A (Montrer HIF1A Anticorps) levels while simultaneously slowing the progression of HIF3A expression until the miR (Montrer MLXIP Anticorps)-429 levels drop below normoxic levels.

Mouse (Murine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

1. Phosphorylation of inhibitory PAS domain protein (IPAS) at Ser184 by MAPK-activated protein kinase 2 (MK2 (Montrer MAPKAPK2 Anticorps) or MAPKAPK2 (Montrer MAPKAPK2 Anticorps)) enhances the proapoptotic function of IPAS.

2. Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a (Montrer HIF1A Anticorps)

3. mRNA of HIF-2alpha (Montrer EPAS1 Anticorps) and Ets-1 (Montrer ETS1 Anticorps) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin (Montrer CDH5 Anticorps) gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin (Montrer CDH5 Anticorps) gene.

4. our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf (Montrer VEGFA Anticorps) in bone, which explain, at least in part, the small body size of Tnni2K175del mice

5. Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha (Montrer HIF1A Anticorps) and HIF-3alpha expression.

6. alternative splicing and expression of IPAS is induced by hypoxia.

7. By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling.

8. Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta (Montrer ARNT Anticorps).

Cow (Bovine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners