IQ Motif and Sec7 Domain 1 Protéines (IQSEC1)

In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.. De plus, nous expédions IQSEC1 Anticorps (10) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
IQSEC1 9922 Q6DN90
IQSEC1 232227 Q8R0S2
Rat IQSEC1 IQSEC1 686590  
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
Détails

IQSEC1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour IQ Motif and Sec7 Domain 1 (IQSEC1) partenaires d'interaction

Human IQ Motif and Sec7 Domain 1 (IQSEC1) interaction partners

  1. both Arf6 (Montrer ARF6 Protéines) activation through GluN2B (Montrer GRIN2B Protéines)-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 (Montrer ARF6 Protéines) signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.

  2. Brag2 is essential for developmental and pathological angiogenesis by promoting endothelial cell sprouting through regulation of adhesion by beta1-integrin internalization and link for the first time the process of beta1-integrin endocytosis with angiogenesis.

  3. The EGFR (Montrer EGFR Protéines)-GEP100-Arf6 (Montrer ARF6 Protéines) axis affected the prognosis of patients with primary lung adenocarcinoma.

  4. Data show that co-overexpression of GEP100 and AMAP1 (ASAP1 (Montrer ASAP1 Protéines)) correlates with rapidity of the local recurrence.

  5. GEP100 regulates an Arf6 (Montrer ARF6 Protéines)/ERK (Montrer EPHB2 Protéines)/uPAR (Montrer PLAUR Protéines) signaling cascade in EGF (Montrer EGF Protéines)-induced breast cancer cell invasion.

  6. GEP100 plays a significant role in pancreatic cancer invasion through regulating the expression of E-cadherin (Montrer CDH1 Protéines) and the process of mesenchymal to epithelial transition (MET).

  7. BRAG2 acts at clathrin-coated pits to promote integrin internalization by activating Arf5 and suggest a previously unrecognized role for Arf5 in clathrin-mediated endocytosis of specific cargoes.

  8. GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells.

  9. The PH domain and the interdomain linker of Brag2 may be targets for selectively regulating the activity of Brag2.

  10. Data suggest that GEP100-Arf6 (Montrer ARF6 Protéines)-AMAP1 (Montrer ASAP1 Protéines)-cortactin (Montrer CTTN Protéines) pathway, activated by VEGFR2 (Montrer KDR Protéines), appears to be common in angiogenesis and cancer invasion and metastasis, and provides their new therapeutic targets.

Mouse (Murine) IQ Motif and Sec7 Domain 1 (IQSEC1) interaction partners

  1. The present study provided evidence that BRAG2a is a novel component of the photoreceptor dystrophin (Montrer DMD Protéines)-associated glycoprotein complex (DGC (Montrer GGCX Protéines)), suggesting functional involvement of the BRAG2a-Arf6 (Montrer ARF6 Protéines) pathway downstream of the DGC (Montrer GGCX Protéines).

  2. both Arf6 (Montrer ARF6 Protéines) activation through GluN2B (Montrer GRIN2B Protéines)-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 (Montrer ARF6 Protéines) signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.

  3. BRAG2 localized to postsynaptic processes at bipolar dyads, while BRAG3 localized to postsynaptic components at conventional synapses in mouse retina

Profil protéine IQSEC1

Profil protéine

In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.

Gene names and symbols associated with IQSEC1

  • IQ motif and Sec7 domain 1 (IQSEC1)
  • IQ motif and Sec7 domain 1 (Iqsec1)
  • ARF-GEP100 Protéine
  • ARFGEP100 Protéine
  • AW561907 Protéine
  • BC026481 Protéine
  • BRAG2 Protéine
  • cI-43 Protéine
  • D6Ertd349e Protéine
  • GEP100 Protéine
  • mKIAA0763 Protéine

Protein level used designations for IQSEC1

ADP-ribosylation factors guanine nucleotide-exchange protein 100 , ADP-ribosylation factors guanine nucleotide-exchange protein 2 , IQ motif and SEC7 domain-containing protein 1 , brefeldin A-resistant ARF-GEF2 , brefeldin-resistant Arf-GEF 2 protein

GENE ID SPECIES
9922 Homo sapiens
232227 Mus musculus
686590 Rattus norvegicus
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