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ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. De plus, nous expédions ID4 Anticorps (79) et ID4 Protéines (6) et beaucoup plus de produits pour cette protéine.
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ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states
results indicate that Id4 marks spermatogonial stem cells in the mouse testis.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.
Id4 regulates NKX3.1, Sox9 and PTEN.
Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (Montrer ESR1 Kits ELISA) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary
High expression levels of Id1 (Montrer ID1 Kits ELISA)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell
ID4 promotes mammary gland development by suppressing p38MAPK (Montrer MAPK14 Kits ELISA) activity.
Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.
Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.
id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (Montrer WNT2 Kits ELISA) signaling in the developing AVC endocardium
Study demonstrates that ID4, can promote p53 (Montrer TP53 Kits ELISA)- dependent apoptosis and senescence in prostate cancer cells by specifically modifying the acetylation of p53 (Montrer TP53 Kits ELISA), which increases its transcriptional activity and promotes the expression of pro-apoptotic and cell cycle regulatory genes.
The cellular uptake of inhibitor of DNA binding 4 protein (ID4) resulted in increased apoptosis, decreased proliferation and colony formation.
Several lines of evidence suggest ID4 may suppress BRCA1 function in basal-like breast cancer (BLBC) and in doing so, define a subset of BLBC patients who may respond to therapies traditionally used in BRCA1-mutant cancers. This review highlights recent advances in our understanding of the requirement for ID4 in mammary lineage commitment and the role for ID4 in BLBC.
The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC) patients, and overexpression of Id4 promoted HCC cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.
ID4 selectively regulates AR activity through direct interaction with FKBP52 (Montrer FKBP4 Kits ELISA).
High ID4 expression is associated with basal breast cancer.
A cell-autonomous positive-signaling circuit is associated with the PDGFB (Montrer PDGFB Kits ELISA)-NO-ID4-regulatory axis in glioblastoma cells.
ID4 expression induces AR expression in PC3 (Montrer PCSK1 Kits ELISA) cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.
CEACAM1 (Montrer CEACAM1 Kits ELISA) is able to maintain the active transcription of ID4 by an epigenetic mechanism involving HDAC4 (Montrer HDAC4 Kits ELISA) and CaMK2D (Montrer CAMK2D Kits ELISA), and the same kinase enables lumen formation by CEACAM1 (Montrer CEACAM1 Kits ELISA)
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (Montrer NR4A2 Kits ELISA))early growth response (EGR)2 (Montrer EGR2 Kits ELISA) and NR4A2EGR3. Therefore, RUNX1 (Montrer RUNX1 Kits ELISA), NR4A2 (Montrer NR4A2 Kits ELISA), EGR2 (Montrer EGR2 Kits ELISA), EGR3 (Montrer EGR3 Kits ELISA) and ID4 may be key genes associated with the pathogenesis of DS.
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.
DNA-binding protein inhibitor ID-4
, inhibitor of DNA binding 4 a
, class B basic helix-loop-helix protein 27