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IP6K3 encodes a protein that belongs to the inositol phosphokinase (IPK) family.
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Cow (Bovine) Polyclonal IP6K3 Primary Antibody pour ELISA - ABIN4227719
Saiardi, Nagata, Luo, Snowman, Snyder: Identification and characterization of a novel inositol hexakisphosphate kinase. dans The Journal of biological chemistry 2001
High levels of IP6K3 mRNA were found in myotubes and muscle tissues. In myotubes, IP6K3 was upregulated by dexamethasone treatment, which is known to inhibit glucose metabolism.
High levels of IP6K3 mRNA were found in myotubes and muscle tissues. Expression was elevated under diabetic, fasting, and disuse conditions in mouse skeletal muscles. Ip6k3(-/-) mice had lower blood glucose, less insulin (Montrer INS Anticorps), decreased fat, lower weight, increased plasma lactate, enhanced glucose tolerance, lower glucose during an insulin (Montrer INS Anticorps) tolerance test, and reduced muscle Pdk4 (Montrer PDK4 Anticorps) expression. Ip6k3 deletion extended lifespan.
IP6K3 is highly expressed in cerebellar Purkinje cells. IP6K3-deleted mice display defects of motor learning and coordination. IP6K3-null mice manifest aberrations of Purkinje cells with a diminished number of synapses.
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein.
inositol hexaphosphate kinase 3
, inositol hexakisphosphate kinase 3
, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
, InsP6 kinase 3
, mitochondrial nucleoid factor 1
, mitochondrial protein M19
, insP6 kinase 3