anti-Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) Anticorps

The protein encoded by INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase.

afficher tous les anticorps Gène GeneID UniProt
Anti-Souris INPP5E INPP5E 64436 Q9JII1
Anti-Rat INPP5E INPP5E 114089  
Anti-Humain INPP5E INPP5E 56623 Q9NRR6
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Top anti-INPP5E Anticorps sur anticorps-enligne.fr

Showing 10 out of 18 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC (p) Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) 0.05 mg Connectez-vous pour afficher 10 to 13 Days
$514.63
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: INPP5E Antibody [NBP2-49463] - Analysis of human cell line U-2 OS shows positivity in the Golgi apparatus, cell junctions & nucleus but excluded from the nucleoli. Immunohistochemistry-Paraffin: INPP5E Antibody [NBP2-49463] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$491.63
Détails
Humain Souris Inconjugué WB Western Blot analysis of INPP5E expression in transfected 293T cell line by INPP5E MaxPab polyclonal antibody.<br><br>Lane 1: INPP5E transfected lysate(70.84 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Connectez-vous pour afficher 11 to 12 Days
$440.00
Détails
Humain Souris Inconjugué WB   50 μg Connectez-vous pour afficher 7 to 9 Days
$837.83
Détails
Humain Lapin Inconjugué WB Western Blot analysis of INPP5E expression in transfected 293T cell line by INPP5E MaxPab polyclonal antibody.<br><br>Lane 1: INPP5E transfected lysate(70.2 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Connectez-vous pour afficher 11 to 12 Days
$425.71
Détails
Humain Lapin Inconjugué WB   100 μL Connectez-vous pour afficher 7 to 9 Days
$581.17
Détails
Humain Lapin Inconjugué ELISA, IF, IHC, IP, WB   100 μg Connectez-vous pour afficher 13 to 16 Days
$380.00
Détails
Humain Lapin Inconjugué IF, IHC, WB   100 μL Connectez-vous pour afficher 11 to 16 Days
$743.29
Détails
Humain Lapin Inconjugué WB   100 μL Connectez-vous pour afficher 2 to 3 Days
$614.84
Détails

Plus d’anticorps contre INPP5E partenaires d’interaction

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT (Montrer AKT1 Anticorps)/GSK3beta signaling axis at cilia in SHH (Montrer SHH Anticorps)-dependent medulloblastoma that is regulated by INPP5E to maintain tumor cell cilia, promote SHH (Montrer SHH Anticorps) signaling and thereby medulloblastoma progression.

  2. we identify Inpp5e as an essential inhibitor of the PI3K/Akt (Montrer AKT1 Anticorps)/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD (Montrer PRKD1 Anticorps)) suppression

  3. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit.

  4. INPP5E is an essential point of convergence between Hedgehog (Montrer SHH Anticorps) and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog (Montrer SHH Anticorps)-dependent embryonic development.

  5. the affinity to PDE6delta and the release by Arl2 (Montrer ARL2 Anticorps)/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.

  6. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  7. Inpp5e, through functional interactions with Rab20 (Montrer RAB20 Anticorps) on the phagosome, activates Rab5 (Montrer RAB5A Anticorps), which, in turn, increases PtdIns3P and delays phagosome acidification.

  8. Inpp5e and SHIP1 (Montrer INPP5D Anticorps) exhibit specificity in regulating FcgammaR- versus CR3 (Montrer ITGAM Anticorps)-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup.

  9. Inpp5e mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in the mouse.

Human Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. INPP5E associates with the N-terminus of RPGR (Montrer RPGR Anticorps) and trafficking of INPP5E to cilia is dependent upon the ciliary localization of RPGR (Montrer RPGR Anticorps).

  2. we identify Inpp5e as an essential inhibitor of the PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps)/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD (Montrer PRKD1 Anticorps)) suppression

  3. ARL13B (Montrer ARL13B Anticorps) regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E.

  4. In neuronal cells, INPP5E knockdown strongly inhibited autophagy by impairing the autophagosome-lysosome fusion step.

  5. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit.

  6. INPP5E is an essential point of convergence between Hedgehog (Montrer SHH Anticorps) and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog (Montrer SHH Anticorps)-dependent embryonic development.

  7. MKS1 (Montrer MKS1 Anticorps) functions in the transition zone at the base of the cilium to regulate ciliary INPP5E content.

  8. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  9. These findings establish the first direct link between AURKA (Montrer AURKA Anticorps) and phosphoinositide signaling and suggest that the function of INPP5E in cilia is at least partly mediated by its interactions with AURKA (Montrer AURKA Anticorps)

  10. Proteomic analysis identified INPP5E, whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D (Montrer PDE6D Anticorps). Mutant PDE6D (Montrer PDE6D Anticorps) shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues.

INPP5E profil antigène

Profil protéine

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome\; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.

Gene names and symbols associated with INPP5E

  • inositol polyphosphate-5-phosphatase E (Inpp5e) anticorps
  • inositol polyphosphate-5-phosphatase E (INPP5E) anticorps
  • 72kDa anticorps
  • 1200002L24Rik anticorps
  • CORS1 anticorps
  • CPD4 anticorps
  • JBTS1 anticorps
  • mKIAA0123 anticorps
  • MORMS anticorps
  • PMPCA anticorps
  • PPI5PIV anticorps

Protein level used designations for INPP5E

72 kDa inositol polyphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase, 72 kDa , phosphatidylinositol 4,5-bisphosphate 5-phosphatase , phosphatidylinositol polyphosphate 5-phosphatase type IV , phosphatidylinositol-4,5-bisphosphate 5-phosphatase , 5-phosphatase that induces arborization , inositol polyphosphate 5-phosphatase , pharbin , phosphatidylinositol (4,5) bisphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase E , peptidase (mitochondrial processing) alpha

GENE ID SPECIES
64436 Mus musculus
114089 Rattus norvegicus
56623 Homo sapiens
748603 Pan troglodytes
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