anti-Interferon Induced Transmembrane Protein 2 (IFITM2) Anticorps

Human Interferon Induced Transmembrane Protein 2 (IFITM2) interaction partners

1. These studies identify a novel role for IFITM1, 2, and 3 in inhibiting HIV replication at the level of translation.

2. overexpression of IFITM1, 2 and 3 suppressed entry of CXCR4 and CCR5 tropic viruses; entry of transmitted founder HIV-1 in U87 cells is more sensitive to inhibition by IFITM2 and IFITM3 than by IFITM1

3. Delta20 IFITM2 may serve as a major contributor to the gatekeeping mechanism that explains restriction of X4 viruses in the early stage of HIV-1 infection

4. These results indicate that IFITM2 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes.

5. The transcriptional regulation of IFITM1, 2 and 3 expression.

6. IFITM2 promotes gastric cancer growth and metastasis via IGF1/IGF1R/STAT3 signaling pathway.

7. findings show that the sensitivity of influenza A viruses to the IFN-induced antiviral state and IFITM2 and IFITM3 proteins depends on the pH value at which the viral HA undergoes a conformational transition and mediates membrane fusion

8. IFITM2 and IFITM3 specifically antagonize the HIV-1 envelope glycoprotein (Env), thereby inhibiting viral infection.

9. propose that the IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation and demonstrate that the actions of the IFITM proteins are indeed virus and cell-type specific

10. G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.

11. In virus-producing cells, IFITMs coalesce with forming virions and are incorporated into HIV-1 viral particles.

12. Incorporation of IFITM1, IFITM2 and IFITM3 into HIV-1 virions impair viral fusion and spread.

13. Host IFITM3,IFITM2 and IFITM1 facilitate morphogenesis of the human cytomegalovirus assembly.

14. Although their inhibitory activities were modest when compared to that of tetherin, IFITMs, but not tetherin, directly reduced the expression of HIV-1 proteins including Gag, Vif and Nef.

15. Authors show that interferon-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity against several members of the Bunyaviridae family.

16. IFITM1, IFITM2, and IFITM3 inhibit HIV-1 replication through interfering with virus entry.

17. IFITM2 and IFITM3, disrupted early steps (entry and/or uncoating) of the viral infection, viperin, ISG20, and double-stranded-RNA-activated protein kinase, inhibited steps in west nile virus and dengue virus viral proteins and/or RNA biosynthesis.

18. Single Nucleotide Polymorphisms in 1-8D is associated with neoplasms.

Mouse (Murine) Interferon Induced Transmembrane Protein 2 (IFITM2) interaction partners

1. this study shows that IFITM2 drives type 2 T helper cell differentiation and exacerbate allergic airway inflammation