Interferon-Induced Protein with Tetratricopeptide Repeats 2 Protéines (IFIT2)

IFIT2 encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. De plus, nous expédions Interferon-Induced Protein with Tetratricopeptide Repeats 2 Anticorps (74) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
IFIT2 3433 P09913
Rat IFIT2 IFIT2 294091  
IFIT2 15958 Q64112
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
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Levure Chinese Hamster His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,314.67
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IFIT2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2) partenaires d'interaction

Human Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2) interaction partners

  1. The results of the present study revealed that the inhibition of proteasome activity blocked the degradation of IFIT2 and promoted the aggregation of IFIT2 in the centrosome, which in turn induced cell apoptosis. In short, IFIT2 may be a potential target for cancer therapeutics.

  2. Mechanistic investigations reveal that AJUBA specifically binds the FERM domain of JAK1 to dissociate JAK1 from the IFNgamma recepter, resulting in an inhibition of STAT1 phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA in CRC specimens is negatively correlated with the levels of IFIT2 and pSTAT1

  3. LINC00161 is an essential regulator in cisplatin-induced apoptosis, and the LINC00161-miR-645-IFIT2 signalling axis plays an important role in reducing osteosarcoma chemoresistance.

  4. there is a positive feedback loop between phosphorylated STAT1 and ISG56, ISG54 or ISG60.

  5. Data show that interferon-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 and IFIT2) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps.

  6. Data shows that IFIT2 expression is downregulated in adenocarcinoma of gastric esophageal junction cells; its ectopic expression leads to cell apoptosis, suggesting its role as a tumor suppressor.

  7. IFIT2, a protein responsible for interferon stimulation, may prevent oral squamous cell carcinoma (OSCC) metastasis and serve as a valuable prognostic marker.

  8. ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation.

  9. Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.

  10. The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls.

  11. role of ISG54 in the induction of apoptosis via a mitochondrial pathway shedding new light on the mechanism by which IFN elicits anti-viral and anti-cancer effects

  12. The expression of interferon-induced genes IFI-54K and IFI-56K in the infected cells was found to increase 50-100-fold

  13. We observed that, although double-stranded RNA or Sendai virus infection induced the two genes with similar kinetics, their induction kinetics in response to interferon-beta were quite different.

  14. IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma.

  15. IFIT2/GARG39 was identified as a microtubule-associated protein enriched in the mitotic spindle of mouse NIH3T3 and B16F10 melanoma cells.

Mouse (Murine) Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2) interaction partners

  1. The authors provide evidence that IFIT2 increases the pathological effects of invasive Candida albicans and that administration of interferon-beta has deleterious effects during infection.

  2. this study shows that activation of IRF3 contributes to IFN-gamma and ISG54 expression during the immune responses to B16F10 tumor growth

  3. Ifit2 exerts its antiviral effect mainly at the level of viral replication, as opposed to functioning as a mechanism that restricts viral entry/egress or transports rabies virus particles through axons.

  4. the mechanism for the observed differential induction of the mouse Ifit1, Ifit2, and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8), which is highly expressed in B cells, played an essential role in this regulation.

  5. These results indicate that high Sendai virus replication in the lungs of infected Ifit2(-/-) mice cooperates with elevated IFN-beta induction to cause disease.

  6. Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus.

  7. Ifit2 is a positive regulator of IFN-alpha/beta expression during mouse hepatitis virus induced encephalitis.

  8. IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-alpha secretion and LPS-induced endotoxin shock.

  9. These results suggest that Ifit2 restricts West Nile virus infection and pathogenesis in different tissues in a cell type-specific manner.

  10. results indicate that in the brain, but not in other organs, Ifit2 is a major mediator of IFN's protective effect against VSV

  11. Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.

  12. results demonstrate that the 2'-O methylation of the 5' cap of viral RNA functions to subvert innate host antiviral responses through escape of IFIT-mediated suppression

  13. Expression increased significantly during LCMV and WNV infection, being widespread and localized predominantly to common as well as distinct neuronal populations in the brain.

  14. Our findings provide the first evidence of a differential pattern of expression of ISG54 and ISG56 genes by IFN-alpha and IFN-beta.

  15. IFIT-2 may affect selectively LPS induced protein expression probably by regulation at different posttranscriptional levels

  16. IFIT2/GARG39 was identified as a microtubule-associated protein enriched in the mitotic spindle of mouse NIH3T3 and B16F10 melanoma cells.

Profil protéine Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2)

Profil protéine

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.

Gene names and symbols associated with IFIT2

  • interferon induced protein with tetratricopeptide repeats 2 (IFIT2)
  • interferon-induced protein with tetratricopeptide repeats 2 (Ifit2)
  • interferon-induced protein with tetratricopeptide repeats 15 (ifit15)
  • interferon induced protein with tetratricopeptide repeats 2 (Ifit2)
  • AV302338 Protéine
  • cig42 Protéine
  • DKFZp468G198 Protéine
  • G10P2 Protéine
  • GARG-39 Protéine
  • IFI-54 Protéine
  • IFI-54K Protéine
  • Ifi54 Protéine
  • IFIT-2 Protéine
  • ISG-54 K Protéine
  • ISG-54K Protéine
  • ISG54 Protéine
  • P54 Protéine
  • wu:fb58d07 Protéine

Protein level used designations for IFIT2

Interferon, alpha-inducible protein (MW 54kD) , interferon-induced 54 kDa protein , interferon-induced protein 54 , interferon-induced protein with tetratricopeptide repeats 2 , GARG-39 , IFI-54K , IFIT-2 , glucocorticoid-attenuated response gene 39 protein

GENE ID SPECIES
3433 Homo sapiens
294091 Rattus norvegicus
322336 Danio rerio
450585 Pan troglodytes
479183 Canis lupus familiaris
527528 Bos taurus
695452 Macaca mulatta
100173024 Pongo abelii
100341555 Oryctolagus cuniculus
100584973 Nomascus leucogenys
15958 Mus musculus
100763118 Cricetulus griseus
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