anti-Interleukin 17 (IL17) Anticorps

Human Interleukin 17 (IL17) interaction partners

1. study indicates that IL-17A enhances proliferation and osteogenic differentiation of SHED by regulating OPG/RANKL mechanism thus suggests therapeutic potential of IL-17A in bone regeneration.

2. These data suggest that a gene signature of IL-17 airway epithelial response distinguishes a biologically, radiographically, and clinically distinct COPD subgroup that may benefit from personalized therapy.

3. rs4711998 and rs8193036 polymorphisms not associated with bronchiolitis at less than six months of age or postbronchiolitis asthma at 11-13 years of age

4. Kinases SphK1 and SphK2 regulate IL-17 expression in human T cells.

5. pneumococcal carriage initiates an IL-17A-mediated immune response in nasopharyngeal adenoids

6. IL-17A may be a target for future CRC immunotherapy.

7. PD-1(+)CD4(+) T cells with reduced proliferative capacity and increased transforming growth factor-beta (TGF-beta)/interleukin-17A (IL-17A) expression were detected in idiopathic pulmonary fibrosis.

8. IL-17A-inhibited autophagy is related to Bcl2 degradation in hepatocellular carcinoma (HCC) cells. Bcl2 may be degraded via the autophagosome-lysosome pathway in HCC cells.

9. this study shows that IL-6 and type-I collagen production by Systemic Sclerosis fibroblasts are differentially regulated by IL-17A in the presence of TGF-beta 1

10. there was a significant difference in the serum levels of IL-6 and IL-17a between patients and controls, and the elevated levels of these two cytokines associated significantly with poor outcome in breast cancer patients and, therefore, can be used as prognostic markers.

11. Opioid requirements during and after orthognathic surgery are enhanced in carriers of the AA genotype of the rs2275913 SNP of the IL-17A gene.

12. This review elaborated the relationship between IFN-gamma and IL-17 in the progress of periodontitis, providing new explanations into the development of periodontitis and alveolar bone destruction caused by the host immune response [review]

13. Study demonstrated that rs763780 CC functional polymorphism of IL-17A as well as IL-17 serum levels are significantly related to the risk of knee osteoarthritis susceptibility in Han Chinese population.

14. IL-17 and CD40L synergistically mediate the inflammatory response and remodelling associated with tissue injury and glomerular sclerosis in diabetic nephropathy.

15. IL-17A -737T/C, -444A/G, -197G/A, and -121G/A SNPs are not risk factors for rheumatoid arthritis, but the IL-17A TAGA haplotype is a risk factor for systemic lupus erythematosus.

16. this study shows that IL-17A attenuates IFN-lambda expression by inducing suppressor of cytokine signaling expression in airway epithelium

17. highly likely that the pathogenesis of knee osteoarthritis in Chinese Han population is positively related to the genotype AA and allele A of IL-17A

18. The results suggested that elevated IL-17A and IL-9 expressions and decreased levels of adipsin and CCL11 were positively associated with adult asthma.

19. The molecular analysis revealed strong cooperative effects of IL-17A and IL-36 cytokines in regulating target genes, which was dependent on the proteolytic activation of the latter. Together these findings suggest an amplification cycle that can be initiated by IL-17A, involving IL-36 cytokines and immune cell derived proteases and resulting in active IL-36 cytokines which synergize with IL-17A

20. Polymorphisms of the rs3819024 and rs8193037 loci of the IL-17A gene are not associated with the susceptibility to ischemic stroke among ethnic Han Chinese from Guangxi.

Horse (Equine) Interleukin 17 (IL17) interaction partners

1. Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO) horses.

2. cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells

3. This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

4. The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.

Mouse (Murine) Interleukin 17 (IL17) interaction partners

1. these results support a protective role of HDAC2 in HDM-induced airway inflammation by suppressing IL-17A production and might suggest that activation of HDAC2 and/or inhibition of IL-17A production could prevent the development of allergic airway inflammation.

2. During lung inflammation, IL-33 and leukotrienes synergistically induce ILC217s. ILC217s are a highly pathogenic and unexpected source for IL-17 in lung inflammation.

3. B cells produced high levels of the tissue-protective protein, Resistin-like molecule alpha (RELMalpha), which then downregulated IL-17A expression.

4. Secretion of interleukin (IL)-17A, IL-17F, IL-1beta, and interferon-gamma was increased upon exposure lymphoid cells to Giardia lamblia.

5. computational analysis identified IL-17A's early, central organizing role in the rapid evolution of a network of inflammatory mediators that induce neutrophil infiltration and neutrophil extracellular trap formation responsible for hepatic damage after liver ischemia reperfusion

6. key roles for TNF and, to a lesser extent, IL-17 as mediators of liver inflammation and fibrosis induced by constitutive NLRP3 inflammasome activation in myeloid-derived cells.

7. Arid5a orchestrates a feed-forward amplification loop, which promoted IL-17 signaling by controlling mRNA stability and translation

8. The results indicated that S100A9 gene silencing suppressed the release of pro-inflammatory cytokines through blocking of the IL-17 pathway in acute pancreatitis (AP).

9. IL-17A contributed to an enhanced inflammatory response during the coinfection with Leishmania major and Staphylococcus aureus in a mouse model.

10. In serum of human IL-1c transgenic mice, IL-6 and IL-17 levels significantly increased, and signal transducer and activator of transcription 3 (Stat3) was activated in joints.

11. GLK induces IL-17A transcription by activating AhR and ROR-gammat.GLK controls IL-17A production and autoimmune responses through AhR.

12. these data suggest a mechanism in which macrophage ATF3 promotes IL-17A production in gammadelta T cells to rapidly induce host defenses during early S. pneumoniae infection.

13. IL-17A modulates apoptosis of osteoclast precursors through Beclin1-autophagy-TRAF3 signaling pathway, thereby influencing osteoclastogenesis.

14. In conclusion, these results demonstrate that eosinophils control IL-17-mediated response and contribute to lung pathology after Aspergillus fumigatus infection.

15. Via noncanonical Wnt signaling and IL-17A-related pathways.

16. Combination treatment of IL-17A mAb.

17. IL17 role in the lung mucous cell hyperplasia caused by respiratory syncytial virus infection.

18. Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1beta and IL-17A.

19. study revealed that miR-340 can specifically bind to the 3' untranslated region of mouse IL-17A and downregulate the expression of endogenous IL-17A.

20. revealed that IL-17 induced the infiltration of a specific subtype of macrophages to aggravate fibrosis through an monocyte chemotactic protein-dependent mechanism

Cow (Bovine) Interleukin 17 (IL17) interaction partners

1. These results support previous gene transcription studies and extend the observation of increased IL-22 and IL-17A responses in M. bovis-infected animals to the level of protein production.

2. calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.

3. Data show that CD4(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.

4. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.

5. IL-17A and IL-17F have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.

6. The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.

Pig (Porcine) Interleukin 17 (IL17) interaction partners

1. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.

2. Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.

3. conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3(+)CD4(+) and CD3(+)gammadeltaTCR(+).

4. Cloning and expression of interleukin-17.

Guinea Pig Interleukin 17 (IL17) interaction partners

1. molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.

Rabbit Interleukin 17 (IL17) interaction partners

1. one of the interaction sites between IL17A and its receptor IL17RA