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The protein encoded by IL22RA2 is a soluble class II cytokine receptor.
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Human Polyclonal IL22RA2 Primary Antibody pour IHC, IHC (p) - ABIN4324964
Laaksonen, Guerreiro-Cacais, Adzemovic, Parsa, Zeitelhofer, Jagodic, Olsson: The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation. dans Genes and immunity 2014
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suggest that the human IL-22BP isoforms have distinct spatial and temporal roles and coordinately fine-tune IL-22 (Montrer IL22 Anticorps)-dependent STAT3 (Montrer STAT3 Anticorps) responses in tissues as a type of rheostat.
thia study shows shows that nonaffected skin of psoriasis patients displays lower expression of IL-22BP than skin of healthy controls, and that the strong IL-22 (Montrer IL22 Anticorps) increase in lesional psoriatic skin is accompanied by a moderate induction of IL-22BP
The deletion of IFNGR1 (Montrer IFNGR1 Anticorps) causes complete IFN-gammaR1 deficiency. Despite the deletion ending very close to the IL22RA2 gene, it does not appear to affect IL22RA2 transcription.
IL-22BP is produced by eosinophils in the gut (Montrer GUSB Anticorps) and blocks IL-22 (Montrer IL22 Anticorps) protective actions in colitis.
Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene.
The IL-22R (Montrer IL22RA1 Anticorps) and IL-10R2 (Montrer IL10RB Anticorps) binding sites are juxtaposed on adjacent IL-22 (Montrer IL22 Anticorps) surfaces contributed mostly by helices A, D, and F and loop AB.
Crystallization and preliminary X-ray diffraction results of the IL-22-IL-22 (Montrer IL22 Anticorps) binding protein (IL-22BP) complex are described.
Comparison of IL-22 (Montrer IL22 Anticorps)/IL-22BP and IL-22 (Montrer IL22 Anticorps)/IL-22R1 crystal structures shows that both receptors display an overlapping IL-22 (Montrer IL22 Anticorps) binding surface, which is consistent with the inhibitory role played by IL-22 (Montrer IL22 Anticorps) binding protein.
Polymorphisms in IL22RA1 (Montrer IL22RA1 Anticorps) are associated with severe CRS (Montrer CARS Anticorps).
Il22bp-deficient mice were more susceptible to acute liver damage in models of acute liver damage induced by ischemia reperfusion and acetaminophen administration. IL-22BP plays a protective role in acute liver damage, via controlling IL-22 (Montrer IL22 Anticorps)-induced Cxcl10 (Montrer CXCL10 Anticorps) expression.
IL-22BP promotes bacterial uptake into Peyer's patches by influencing follicle-associated epithelium gene expression and function.
IL22RA2 KO displayed a less severe EAE course, less demyelination and less infiltration of immune cells in the CNS.
the IL-22 (Montrer IL22 Anticorps)-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon
cloning and characterization; gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 (Montrer IL22 Anticorps) binding protein; upregulated by LPS (Montrer TLR4 Anticorps) stimulation in monocytes
The protein encoded by this gene is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
interleukin 22-binding protein
, interleukin 22 receptor, alpha 2
, interleukin 22-binding protein-like
, cytokine receptor class-II member 10
, cytokine receptor family type 2, soluble 1
, interleukin-22 receptor subunit alpha-2
, IL-22 receptor subunit alpha-2
, cytokine receptor family II soluble 1
, interleukin-22-binding protein