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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. De plus, nous expédions IL27 Kits (58) et IL27 Protéines (26) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 164 products:
Mouse (Murine) Monoclonal IL27 Primary Antibody pour ICS, Neut - ABIN2689756
Hall, Silver, Hunter: The immunobiology of IL-27. dans Advances in immunology 2012
Show all 7 Pubmed References
Mouse (Murine) Monoclonal IL27 Primary Antibody pour FACS - ABIN4896017
Yoshida, Yoshimi, Yoshii, Kim, Dey, Xiong, Munasinghe, Yazawa, ODonovan, Maximova, Sharma, Zhu, Wang, Morse, Ozato: The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. dans Immunity 2014
Mouse (Murine) Monoclonal IL27 Primary Antibody pour WB - ABIN1043835
Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. dans Proceedings of the National Academy of Sciences of the United States of America 2010
Mouse (Murine) Polyclonal IL27 Primary Antibody pour WB - ABIN1043831
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. dans Immunity 2002
Human Monoclonal IL27 Primary Antibody pour CyTOF, FACS - ABIN4900122
Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. dans European journal of immunology 2010
IL-27 rs153109 and rs17855750 Polymorphisms are associated with Risk and Response to Therapy in Acute Lymphoblastic Leukemia.
IL-27 was down-regulated in the malignant Middle Cerebral Artery Infarction.
IL-27 may be involved in the development of coronary artery lesions in acute Kawasaki disease.
Hepatitis B virus infection can lead to overexpression of interleukin-27 gene in liver transplant patients.
this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer
IL-27 signaling (IL-27 and its receptor) may be involved in the pathogenesis of HIV infection and immune reconstitution in HIV/AIDS patients who underwent HAART. IL-27 may exert effects through regulating Th1 (Montrer TH1L Anticorps) / Th2 ratio.
This study provides additional evidence that IL-27 may contribute to autoimmune processes in MS patients.
this study shows that IL-27 regulates the adherence, proliferation, and migration of placenta-derived mesenchymal stromal cells and enhances their regulatory effects on Th1 (Montrer TH1L Anticorps) and Th2 subset generations
This study failed to find an association between common variants in the functional region of IL27 and coronary artery disease in a Chinese Han population
Data point out to a broad set of activities shared by IL-27 and IFN-gamma (Montrer IFNG Anticorps), which are dependent on the common activation of the STAT1 (Montrer STAT1 Anticorps) pathway. These data add further explanation to the anti-tumor activity of IL-27 and also to its dual role in immune regulation
Mechanistic studies have identified that hyperlipidemia induces IL-27 production in a TLR4 (Montrer TLR4 Anticorps)-dependent manner, likely via downregulating LXR (Montrer NR1H3 Anticorps) expression in dendritic cells. In this case, mice lacking IL-27 do not develop enhanced antibody responses.
IFN-gamma (Montrer IFNG Anticorps) induces IL-30 production which suppresses IFN-gamma (Montrer IFNG Anticorps) mediated liver inflammation.
IL-27 signaling in Foxp3 (Montrer FOXP3 Anticorps)(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system
this study has revealed an important role of thymic dendritic cells-derived IL-27 in the regulation of the phenotypic maturation of CD4 (Montrer CD4 Anticorps)(+) single positive thymocytes.
TTP (Montrer ZFP36 Anticorps), encoded by Zfp36 (Montrer ZFP36 Anticorps), degrades p28 (Montrer GSTO1 Anticorps) to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.
these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1 (Montrer TXNRD1 Anticorps)-like cells in celiac disease
endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (Montrer TP53 Anticorps) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.
Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (Montrer LTF Anticorps).
Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS (Montrer TLR4 Anticorps) injection compared with control specimens.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit