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Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. De plus, nous expédions ICK Protéines (11) et ICK Kits (9) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 90 products:
Human Polyclonal ICK Primary Antibody pour ICC, IF - ABIN4320963
Häggarth, Hägglöf, Jaraj, Wester, Pontén, Ostman, Egevad: Diagnostic biomarkers of prostate cancer. dans Scandinavian journal of urology and nephrology 2011
Human Polyclonal ICK Primary Antibody pour ELISA, WB - ABIN564945
Vallesi, Di Pretoro, Ballarini, Apone, Luporini et al.: A novel protein kinase from the ciliate Euplotes raikovi with close structural identity to the mammalian intestinal and male-germ cell kinases: characterization and functional implications in the ... dans Protist 2010
Our data provide evidence that heterozygous variants in ICK caused juvenile myoclonic epilepsy in 7% of the patients included in our analysis. Variant ICK affects cell processes that help explain microdysgenesis and polyspike networks observed on EEG in juvenile myoclonic epilepsy.
These data identify ICK as an short rib polydactyly syndromes (SRPS)-associated gene and reveal that abnormalities in signalling pathways contribute to defective skeletogenesis
findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress.
the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation.
High ICK expression is associated with prostate cancer.
an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908.
ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity
ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1, c-Myc and p21Cip1.
ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island.
PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe, an essential regulator of proliferation and apoptosis during mammalian development.
ICK is the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs.
These results suggest that Ick is expressed in proliferating regions in the adult mouse brain, testis, and intestine.
Data indicate an essential role for intestinal cell kinase (ICK) in lung development and advances the mechanistic understanding of endocrine-cerebro-osteodysplasia (ECO) syndrome.
The results of this study found that loss of Ick leads to abnormal localization of the IFT component in kinocilia, PCP defects in HCs, and hearing dysfunction.
Data indicate that ciliary defects caused by a lack of functional intestinal cell kinase (ICK) leads to abnormal Sonic hedgehog (Shh) signaling, resulting in congenital disorders such as endocrine-cerebro-osteodysplasia (ECO) syndrome .
ICK is a Kif3a kinase and essential for proper ciliogenesis in development by regulating ciliary transport at the tip of cilia.
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.
intestinal cell (MAK-like) kinase
, intestinal cell kinase
, serine/threonine-protein kinase ICK-like
, MAK-related kinase
, laryngeal cancer kinase 2
, serine/threonine protein kinase
, serine/threonine-protein kinase ICK
, heart serine-threonine protein kinase