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Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. De plus, nous expédions ICK Protéines (11) et ICK Kits (6) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 76 products:
Human Polyclonal ICK Primary Antibody pour ELISA, WB - ABIN564945
Vallesi, Di Pretoro, Ballarini, Apone, Luporini et al.: A novel protein kinase from the ciliate Euplotes raikovi with close structural identity to the mammalian intestinal and male-germ cell kinases: characterization and functional implications in the ... dans Protist 2010
Human Polyclonal ICK Primary Antibody pour ICC, IF - ABIN4320963
Häggarth, Hägglöf, Jaraj, Wester, Pontén, Ostman, Egevad: Diagnostic biomarkers of prostate cancer. dans Scandinavian journal of urology and nephrology 2011
These data identify ICK as an short rib polydactyly syndromes (SRPS)-associated gene and reveal that abnormalities in signalling pathways contribute to defective skeletogenesis
findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress.
the expressions of ICK/MAK (Montrer MAK Anticorps)/MOK (Montrer MOK Anticorps) proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
In glioblastoma cells with deregulated high levels of CCRK (Montrer CDK20 Anticorps), its depletion restores cilia through ICK and an ICK-related kinase MAK (Montrer MAK Anticorps), thereby inhibiting glioblastoma cell proliferation.
High ICK expression is associated with prostate cancer.
an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor (Montrer RPTOR Anticorps) Thr (Montrer TRH Anticorps)-908.
ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity
ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1 (Montrer CCND1 Anticorps), c-Myc (Montrer MYC Anticorps) and p21Cip1 (Montrer CDKN1A Anticorps).
ICK and FBX9 (Montrer FBXO9 Anticorps) are divergently transcribed from a bidirectional promoter that is GC-rich (Montrer RELB Anticorps) and contains a CpG island.
PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase (Montrer CDK20 Anticorps)) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe (Montrer BAT3 Anticorps), an essential regulator of proliferation and apoptosis during mammalian development.
Data indicate an essential role for intestinal cell kinase (ICK) in lung development and advances the mechanistic understanding of endocrine-cerebro-osteodysplasia (ECO) syndrome.
The results of this study found that loss of Ick leads to abnormal localization of the IFT component in kinocilia, PCP (Montrer BMP1 Anticorps) defects in HCs (Montrer HLCS Anticorps), and hearing dysfunction.
the expressions of ICK/MAK (Montrer MAK Anticorps)/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
Data indicate that ciliary defects caused by a lack of functional intestinal cell kinase (ICK) leads to abnormal Sonic hedgehog (Shh (Montrer SHH Anticorps)) signaling, resulting in congenital disorders such as endocrine-cerebro-osteodysplasia (ECO) syndrome .
ICK is a Kif3a (Montrer KIF3A Anticorps) kinase and essential for proper ciliogenesis in development by regulating ciliary transport at the tip of cilia.
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.
intestinal cell (MAK-like) kinase
, intestinal cell kinase
, serine/threonine-protein kinase ICK-like
, MAK-related kinase
, laryngeal cancer kinase 2
, serine/threonine protein kinase
, serine/threonine-protein kinase ICK
, heart serine-threonine protein kinase