Islet Cell Autoantigen 1, 69kDa Protéines (ICA1)

ICA1 encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. De plus, nous expédions Islet Cell Autoantigen 1, 69kDa Anticorps (88) et Islet Cell Autoantigen 1, 69kDa Kits (9) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
ICA1 15893 P97411
ICA1 81024  
ICA1 3382 Q05084
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Top Islet Cell Autoantigen 1, 69kDa Protéines sur anticorps-enligne.fr

Showing 9 out of 12 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Détails
Escherichia coli (E. coli) Humain His tag 100 μg 11 Days
$356.40
Détails
Levure Humain His tag 100 μg 8 to 11 Days
$429.00
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human ICA1 Protein. 100 μg 11 to 18 Days
$753.31
Détails
Escherichia coli (E. coli) Souris Inconjugué SDS-PAGE analysis of Mouse ICA1 Protein. 100 μg 11 to 18 Days
$781.74
Détails
Levure Rat His tag   1 mg 60 to 71 Days
$3,356.83
Détails

ICA1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) ,

Rat (Rattus)

Human , , , ,
, ,

Plus protéines pour Islet Cell Autoantigen 1, 69kDa (ICA1) partenaires d'interaction

Mouse (Murine) Islet Cell Autoantigen 1, 69kDa (ICA1) interaction partners

  1. The findings of this study indicated that ICA69 mediates the antihyperalgesic effects of EA on CFA-induced inflammatory pain by regulating spinal GluR2 through PICK1 in mice

  2. ICA69 deficiency promoted formalin-induced long-lasting pain hypersensitivity.

  3. direct link between compromised thymic ICA69 expression and autoimmunity against multiple ICA69-expressing organs, and identify a potential novel mechanism for the development of multi-organ autoimmune diseases.

  4. C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCalpha complex and cerebellar plasticity.

  5. PICK1 and ICA69 are key regulators of the formation and maturation of insulin granules.

  6. polymorphisms within the NOD Ica1 core promoter may determine AIRE-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells.

  7. ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide

Human Islet Cell Autoantigen 1, 69kDa (ICA1) interaction partners

  1. C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCalpha complex and cerebellar plasticity.

  2. Novel association was found between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1.

  3. polymorphisms within the NOD Ica1 core promoter may determine AIRE-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells.

  4. The exon A promoter exhibits greater activity in islet cells, whereas the exon B promoter more efficiently activates transcription in neuronal cells.

  5. ICA69 as a novel Rab2 effector and its role in regulating the early transport of insulin secretory granule proteins

Profil protéine Islet Cell Autoantigen 1, 69kDa (ICA1)

Profil protéine

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with ICA1

  • islet cell autoantigen 1 L homeolog (ica1.L)
  • islet cell autoantigen 1 (ICA1)
  • islet cell autoantigen 1 (ica1)
  • Islet cell autoantigen 1 (ica69)
  • islet cell autoantigen 1 (Ica1)
  • islet cell autoantigen 1 S homeolog (ica1.S)
  • 69kDa Protéine
  • DKFZp469G0321 Protéine
  • ICA1 Protéine
  • Ica69 Protéine
  • ICAp69 Protéine
  • MGC52730 Protéine
  • MGC83241 Protéine
  • zgc:92566 Protéine

Protein level used designations for ICA1

islet cell autoantigen 1, 69kDa , Islet cell autoantigen 1 , islet cell autoantigen 1-like , 69 kDa islet cell autoantigen , ICAp69 , islet cell autoantigen 1, 69 kDa , islet cell autoantigen p69 , p69 , diabetes mellitus type I autoantigen , islet cell autoantigen 1 , islet cell autoantigen 1 isoform

GENE ID SPECIES
379786 Xenopus laevis
463264 Pan troglodytes
549616 Xenopus (Silurana) tropicalis
695889 Macaca mulatta
100171501 Pongo abelii
100380590 Salmo salar
100402491 Callithrix jacchus
100511342 Sus scrofa
100585518 Nomascus leucogenys
437003 Danio rerio
15893 Mus musculus
81024 Rattus norvegicus
414587 Xenopus laevis
420581 Gallus gallus
3382 Homo sapiens
475242 Canis lupus familiaris
535346 Bos taurus
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