anti-Jumonji Domain Containing 6 (JMJD6) Anticorps

JMJD6 encodes a nuclear protein with a JmjC domain. De plus, nous expédions Jumonji Domain Containing 6 Protéines (13) et Jumonji Domain Containing 6 Kits (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
JMJD6 360665 Q6AYK2
JMJD6 23210 Q6NYC1
JMJD6 107817 Q9ERI5
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Top anti-Jumonji Domain Containing 6 Anticorps sur

Showing 10 out of 129 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-JMJD6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Hela cell lysate 100 μL 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué IHC, WB IHC Suggested Anti-PTDSR antibody  Titration: 5ug/ ml Positive Control: Breast WB Suggested Anti-PTDSR Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human kidney 100 μL 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-PTDSR Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Thymus 100 μL 2 to 3 Days
Humain Lapin Inconjugué WB JMJD6 Antibody (C-term) (ABIN658081) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the JMJD6 antibody detected the JMJD6 protein (arrow). 400 μL 10 to 11 Days
Humain Lapin Inconjugué WB Western blot analysis of anti-PTDSR (N-term) Pab (ABIN387893) in mouse heart, Hela, and HL60 cell line lysates. PTDSR (N-term)(arrow) was detected using the purified polyclonal antibody. Anti-PTDSR Antibody (N-term) at 1:1000 dilution + human heart lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 47 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL 10 to 11 Days
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB Anti-JMJD6 / PSR antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1102638 dilution 38538 ug/ml. 100 μL 11 to 14 Days
Humain Lapin Inconjugué IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: NIH-3T3 10% SDS PAGE PSR antibody antibody diluted at 1:1000 WB Image Sample (30 ug of whole cell lysate) A: A431 , 10% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
Humain Lapin Inconjugué EIA, WB 0.4 mL 6 to 8 Days
Humain Souris Inconjugué ELISA, WB   100 μL Disponible
Chimpanzé Lapin Inconjugué WB 50 μg 2 to 3 Days

anti-Jumonji Domain Containing 6 Anticorps mieux référencés

  1. Human Polyclonal JMJD6 Primary Antibody pour ELISA, WB - ABIN543181 : Fadok, Bratton, Rose, Pearson, Ezekewitz, Henson: A receptor for phosphatidylserine-specific clearance of apoptotic cells. dans Nature 2000 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal JMJD6 Primary Antibody pour ICC - ABIN1742540 : Hahn, Wegener, Burrells, Böse, Wolf, Erck, Butler, Schofield, Böttger, Lengeling: Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. dans PLoS ONE 2010 (PubMed)

Plus d’anticorps contre Jumonji Domain Containing 6 partenaires d’interaction

Human Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. knockdown of JMJD6 reduces the proliferation, migration and invasion of neuroglioma stem cells

  2. The JMJD6-H2A.X(Y39ph) axis promoted triple negative breast cance cell growth via the autophagy pathway.

  3. results indicate for the first time that JMJD6 plays an important role in the regulation of ADSCs proliferation and migration through the modulation of PDE1C expression.

  4. Consistent with its role in transcriptional activation, JMJD6 is required for estrogen/ERalpha-induced breast cancer cell growth and tumorigenesis, via modulation of recruitment of CARM1/MED12 co-activator complex.

  5. JMJD6 is a novel Stress Granule component that interacts with G3BP1 complexes, and its expression reduces G3BP1 monomethylation and asymmetric dimethylation at three Arg residues.

  6. JMJD6 regulates VHL gene expression in the human placenta. VHL downregulation in preeclampsia is dependent on decreased JMJD6 demethylase activity due to hypoxia and reduced Fe2+ bioavailability.

  7. In tumor samples but not normal breast tissue, the expression of JMJD6 linearly correlated with HOTAIR suggesting that JMJD6-mediated up-regulation may occur specifically in tumors.

  8. Results show that JMJD6 is up-regulated in melanoma, and high expression of JMJD6 protein is strongly correlated with advanced stages and aggressiveness of melanoma. It enhances the MAPK signaling through regulation of alternative splicing of PAK1 promoting multiple cellular processes including melanogenesis, proliferation, invasion, and angiogenesis in melanoma cells.

  9. High JMJD6 expression is associated with Neuroblastomas.

  10. miR-770 acted on a tumor suppressor by binding to the 3'UTR of JMJD6 and downregulated its expression in NSCLC cells; this study also demonstrated that JMJD6 played as an oncogene in NSCLC cells

  11. JMJD6 regulated a large set of alternative splicing events, and importantly, its regulated splicing events were significantly overlapped those controlled by U2AF65.

  12. AcK27-HOXB9 suppresses the transcription of its target gene Jumonji domain-containing protein 6 (JMJD6) by direct occupying the promoter of JMJD6 gene.

  13. These findings provide evidence that JMJD6 may play a role in regulating the production of sFLT-1 in the preeclamptic placenta. Decreased placental JMJD6 expression may be an important component to the pathophysiology of preeclampsia.

  14. Study identified a novel epigenetic mechanism showing how JMJD6 cooperates with Myc during oncogenic transformation. Combined high expression of Myc and JMJD6 confers a more aggressive phenotype in mouse and human tumors.

  15. Our studies identify JMJD6 as a molecular determinant of cancer stem cell phenotype

  16. Although JMJD6 displays anti-tumoral properties in cell lines, its expression in breast tumours may be a marker of poor prognosis, suggesting that its function could be altered in breast cancer

  17. The expression of JMJD6 was reduced in T lymphocytes in chronic hepatitis B.

  18. A novel role for JMJD6 as an oxygen sensor in the human placenta, and alterations in the JMJD6-VHL-HIF1A feedback loop may indirectly contribute to elevated HIF1A found in preeclampsia.

  19. JMJD6 is a potential biomarker for colon cancer aggressiveness and a potential target for colon cancer intervention.

  20. Study reports that a unique cohort of JMJD6 and Brd4 cobound distal enhancers, termed anti-pause enhancers, regulate promoter-proximal pause release of a large subset of transcription units via long-range interactions.

Zebrafish Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. results suggest that YY1a regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development

  2. PSR-dependent system in zebrafish embryos that engulfs apoptotic cells mediated by PSR-phagocytes during development, with the system assuming an important role in the normal development of tissues such as the brain, heart, notochord and somite

Mouse (Murine) Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. TEC-specific deletion of Jmjd6 exacerbates development of autoimmune diabetes in a mouse model, which express both ovalbumin (OVA) under the control of the rat insulin gene promoter and OT-I T cell receptor specific for OVA peptide bound to major histocompatibility complex class I K(b) molecules.

  2. Although Jmjd6 deficiency does not affect abundance of Aire transcript, the intron 2 of Aire gene is not effectively spliced out in the absence of Jmjd6, resulting in reduction of mature Aire protein and spontaneous multi-organ autoimmunity in mice.

  3. The results indicate dual roles for JMJD6 in promoting adipogenic gene expression program by post-transcriptional regulation of C/EBPbeta and C/EBPdelta and direct transcriptional activation of Ppargamma2 and Cebpalpha during adipocyte differentiation.

  4. histones are additional substrates of JMJD6 in vivo. Because 5-hydroxylation of lysyl residues inhibited N-acetylation and N-methylation by an acetyltransferase and a methyltransferase

  5. confirmed that Jmjd6 forms multimers and showed that nuclear localization of the protein involves association with a nucleic acid matrix

  6. protein kinase C beta activation is dependent upon phosphatidylserine receptor action

  7. data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations

  8. during embryonic development, phosphatidylserine receptor-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses

  9. Ptdsr is localized in the cell nucleus via multiple nuclear localization signals.

  10. Ptdsr is essential for the development and differentiation of multiple organs during embryogenesis but not for apoptotic cell clearance.

  11. identified cardiac malformations in Ptdsr deficient embryos, including ventricular septal defects, double-outlet right ventricle, and hypoplasia of the pulmonary artery and thymus.

  12. Results suggest that the presumptive phosphatidylserine receptor is not involved generally in either specific innate recognition or engulfment of apoptotic cells.

Cow (Bovine) Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. JMJD6 contributes to foot-and-mouth disease virus infectivity and may be a previously unidentified foot-and-mouth disease receptor.

  2. Demethylated RHA bound JMJD6 monomer during foot-and-mouth disease virus infection.

Jumonji Domain Containing 6 (JMJD6) profil antigène

Profil protéine

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells\; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with JMJD6

  • arginine demethylase and lysine hydroxylase (Jmjd6) anticorps
  • arginine demethylase and lysine hydroxylase (JMJD6) anticorps
  • jumonji domain containing 6 (jmjd6) anticorps
  • jumonji domain containing 6 (Jmjd6) anticorps
  • bifunctional arginine demethylase and lysyl-hydroxylase PSR (LOC411069) anticorps
  • jumonji domain containing 6 (JMJD6) anticorps
  • jmjC domain-containing protein 4 homolog (LOC5577546) anticorps
  • phosphatidylserine receptor (CpipJ_CPIJ004848) anticorps
  • phosphatidylserine receptor (CpipJ_CPIJ019866) anticorps
  • jumonji domain containing 6 S homeolog (jmjd6.S) anticorps
  • jumonji domain containing 6 L homeolog (jmjd6.L) anticorps
  • 5730436I23Rik anticorps
  • cg5383 anticorps
  • D11Ertd195e anticorps
  • GB15204 anticorps
  • jmjd6 anticorps
  • mKIAA0585 anticorps
  • psr anticorps
  • PtdSerR anticorps
  • ptdsr anticorps
  • ptdsr1 anticorps
  • zfpsr anticorps
  • zgc:66264 anticorps

Protein level used designations for JMJD6

bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 , histone arginine demethylase JMJD6 , jmjC domain-containing protein 6 , jumonji domain-containing protein 6 , lysyl-hydroxylase JMJD6 , peptide-lysine 5-dioxygenase JMJD6 , phosphatidylserine receptor , jumonji domain containing 6 , apoptotic cell clearance receptor PtdSerR , protein PTDSR , Histone arginine demethylase JMJD6 , bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-B , histone arginine demethylase JMJD6-B , jmjC domain-containing protein 6-B , jumonji domain-containing protein 6-B , lysyl-hydroxylase JMJD6-B , peptide-lysine 5-dioxygenase JMJD6-B , phosphatidylserine receptor-B , protein PTDSR-B , bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A , histone arginine demethylase JMJD6-A , jmjC domain-containing protein 6-A , jumonji domain-containing protein 6-A , lysyl-hydroxylase JMJD6-A , peptide-lysine 5-dioxygenase JMJD6-A , phosphatidylserine receptor-A , protein PTDSR-A

360665 Rattus norvegicus
23210 Homo sapiens
266962 Danio rerio
100230335 Taeniopygia guttata
107817 Mus musculus
411069 Apis mellifera
417355 Gallus gallus
508343 Bos taurus
5577546 Aedes aegypti
6036446 Culex quinquefasciatus
6054124 Culex quinquefasciatus
468338 Pan troglodytes
548957 Xenopus (Silurana) tropicalis
100173544 Pongo abelii
380206 Xenopus laevis
444377 Xenopus laevis
483335 Canis lupus familiaris
100722696 Cavia porcellus
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