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Oral white sponge nevus may manifest variable clinical features. The novel mutation found in the KRT13 gene is believed to add evidence for a mutational hotspot in the mucosal keratins
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this study reports that KRT13 plays a directive role in prostate cancer bone, brain, and soft tissue metastases
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Keratin 13 gene is epigenetically suppressed during TGFB1-induced epithelial-mesenchymal transition in a human keratinocyte cell line.
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Four rare missense variants were identified (ACTBL2 rs73757391 (5q11.2), BTD rs200337373 (3p25.1), KRT13 rs150321809 (17q21.2) and MC2R rs104894658 (18p11.21)), but only MC2R rs104894668 had a large effect size (OR = 9.66).
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KRT13 expression is associated with poor prognosis at multiple stages of disease progression
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Loss of CK13 expression is associated with invasive oral squamous cell carcinoma.
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Low KRT13 mRNA expression is associated with oral squamous cell carcinoma.
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Decreased KRT13 was associated with Esophageal Squamous Cell Carcinoma.
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Our data provide mechanistic insights into the epigenetic silencing of KRT13 genes in OSCC cells and might be useful for the development of diagnostic markers and novel therapeutic approaches against OSCCs.
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The immunofluorescent staining pattern of Wnt1 and CK7 as well as Wnt1 and CK13 was consistent with IHC results. Thus, in pleomorphic adenoma, Wnt is involved in tumor cell differentiation of peripheral columnar cells forming solid nests
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keratin14 expression can be used to detect early epithelial dysplasia, and that keratin13 and keratin17 expression are useful for detecting neoplastic changes
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Immunoexpression of CK13 and CK17 in light green-stained superficial cells was associated with more severe morphological atypia in tongue squamous cell carcinoma
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Fluorescent keratin 13 integrates into the endogenous keratin cytoskeleton in human vulva carcinoma-derived A431 cells, thereby serving as a reliable marker of keratin dynamics.
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Loss of K13 in oral carcinoma in situ is partly due to its gene repression, but may also be due to some unknown post-translational events.
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The aberrant expression of K4 and K13 and concomitant up-regulation of the other keratins may be one of the causative factors for morphological alterations in the affected epithelium.
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Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19.
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CK13 expression is elevated in KB cells treated with all-trans retinoic acid or arsenic trioxide.
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Expression was altered in oral lichen planus lesions
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exhibits a regular expression pattern in luminal epithelial cells of secretory phase human endometrium
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Metaplastic squamous cells differentiate with a decrease of CK18 and an increase of CK13 expression.
