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Plays a central role in hair and nail formation. De plus, nous expédions Keratin 75 Anticorps (52) et Keratin 75 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Studies show that mutation in epithelial hair keratin KRT75 leads to a skin condition called pseudofollicularis barbae. Carriers of this mutation have an altered enamel structure and mechanical properties leading to much higher prevalence of caries. [review]
The expression of CK5/6 and of P63 suggests a squamous differentiation including in the basaloid thyroid lymphoepithelial complexes
CK5/6 have roles in biologically aggressive tumors likely to display resistance to trastuzumab ab initio in women diagnosed with HER2+ cancer
There were differences between CK5/6, p63,CK34betaE12 and TTF-1 expression with tumor differentiation in squamous cell carcinoma or adenocarcinomas
Analysis of teeth from individuals carrying the KRT75(A161T) variant revealed an altered enamel structure and a marked reduction of enamel hardness, suggesting that a functional keratin network is required for the mechanical stability of tooth enamel.
we observed a possible association between CK5/6 expression in the primary tumor and multiple versus solitary breast carcinoma brain metastasis
K75 expression is closely associated with the process of desquamation of the inner root sheath of hair follicles.
Cytokeratin 5/6 can be a useful adjunct in cases with ductal hyperplasia but not in columnar cell lesions, on breast core biopsies
Positive staining for CK5/6 or CK17 was associated with a worse prognosis, high tumor grade and positive axillary lymph nodes.
mK6a and mK75 thus exhibit temporally distinct, and spatially opposed, expression patterns in the companion layer (Cl) during postnatal anagen.
Mice expressing mutant form of Krt75 developed hair and nail defects resembling pachyonychia congenita
Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
cytokeratin type II
, type II alpha-keratin IIB
, keratin 75
, keratin, type II cytoskeletal 75
, keratin-6 hair follicle
, type II keratin-18
, type II keratin-K6hf
, type-II keratin Kb18
, cytokeratin KRT2-6HF
, keratinocyte associated protein 1
, type II keratin Kb18