Ketohexokinase Protéines (KHK)

KHK encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. De plus, nous expédions Ketohexokinase Anticorps (139) et Ketohexokinase Kits (10) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
KHK 16548 P97328
Rat KHK KHK 25659 Q02974
KHK 3795 P50053
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Top Ketohexokinase Protéines sur anticorps-enligne.fr

Showing 10 out of 15 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Escherichia coli (E. coli) Humain Inconjugué 0.05 mg Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Escherichia coli (E. coli) Humain Inconjugué Figure annotation denotes ug of protein loaded and % gel used. 100 μg Connectez-vous pour afficher 6 to 8 Days
$322.14
Détails
Human Cells Humain His tag   50 μg Connectez-vous pour afficher 4 Days
$352.00
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Human Cells Humain His tag   10 μg Connectez-vous pour afficher 15 to 16 Days
$212.50
Détails
Levure Orang-Utan His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,786.67
Détails
Escherichia coli (E. coli) Humain Inconjugué   1 mg Connectez-vous pour afficher 2 to 3 Days
$3,055.38
Détails

KHK Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , , , ,
, ,

Plus protéines pour Ketohexokinase (KHK) partenaires d'interaction

Mouse (Murine) Ketohexokinase (KHK) interaction partners

  1. This studies provided the first evidence that fructokinase modulates vasopressin (Montrer AVP Protéines) synthesis in the SON and secretion from the posterior pituitary into circulation.

  2. Fructokinase knockout mice were protected from renal injury both at baseline and after high salt intake (3 wk) compared with wild-type mice. This was associated with higher levels of active (phosphorylated serine 1177) endothelial nitric oxide synthase (Montrer NOS3 Protéines) in their kidneys.

  3. Feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations.

  4. Significant levels of blood fructose are maintained independent of dietary fructose, KHK, and GLUT5, probably by endogenous synthesis of fructose.

  5. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (Montrer HIF1A Protéines)) activation of SF3B1 (Montrer SF3B1 Protéines) and SF3B1 (Montrer SF3B1 Protéines)-mediated splice switching of KHK-A to KHK-C

  6. Fructokinase-knockout mice with delayed hydration were protected from renal injury. Thus, recurrent dehydration can induce renal injury via a fructokinase-dependent mechanism, likely from the generation of endogenous fructose via the polyol pathway.

  7. This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin (Montrer INS Protéines) resistance induced by high fructose, a widespread component of Western diets.

  8. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.

  9. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.

  10. Fructose-induced metabolic syndrome is prevented in mice lacking both fructokinase B and A but is exacerbated in mice lacking fructokinase A.

Human Ketohexokinase (KHK) interaction partners

  1. Data indicate metabolic enzymes NAD kinase (Montrer NADK Protéines) and ketohexokinase as candidate metabolic gene targets, and the chromatin remodeling protein INO80C (Montrer INO80C Protéines) as a tumor suppressor in KRAS(MUT (Montrer MUT Protéines)) colorectal tumor xenograft.

  2. Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C.

  3. compared with normal hepatocytes, hepatocellular carcinoma (HCC (Montrer FAM126A Protéines)) cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc (Montrer MYC Protéines)-dependent and heterogeneous nuclear ribonucleoprotein (Montrer PCBP2 Protéines) (hnRNP (Montrer HNRNPC Protéines)) H1- and H2-mediated switch from expression of the high-activity fructokinase (KHK)-C to the low-activity KHK-A isoform.

  4. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (Montrer HIF1A Protéines)) activation of SF3B1 (Montrer SF3B2 Protéines) and SF3B1 (Montrer SF3B2 Protéines)-mediated splice switching of KHK-A to KHK-C

  5. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.

  6. This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 and SLC2A5 and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes.

  7. In human hepatocytes uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose.

  8. ketohexokinase-A serves an unknown physiologic function that remains intact in essential fructosuria.

  9. The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma (Montrer MOK Protéines)

  10. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.

Profil protéine Ketohexokinase (KHK)

Profil protéine

This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Ketohexokinase Protéines (KHK)

  • ketohexokinase (KHK)
  • ketohexokinase (khk)
  • ketohexokinase (Hhal_0921)
  • ketohexokinase (AaeL_AAEL006316)
  • Ketohexokinase (Nwat_0240)
  • ketohexokinase (Khk)
  • KETHPRO Protéine
  • khk Protéine
  • wu:fj68h03 Protéine
  • zgc:92219 Protéine
  • zgc:92626 Protéine

Protein level used designations for Ketohexokinase Protéines (KHK)

ketohexokinase , Ketohexokinase , hepatic fructokinase

GENE ID SPECIES
100055449 Equus caballus
436909 Danio rerio
698328 Macaca mulatta
4710193 Halorhodospira halophila SL1
5567860 Aedes aegypti
9391692 Nitrosococcus watsonii C-113
100306748 Salmo salar
100351729 Oryctolagus cuniculus
16548 Mus musculus
25659 Rattus norvegicus
3795 Homo sapiens
100170647 Canis lupus familiaris
614868 Bos taurus
100447147 Pongo abelii
100523241 Sus scrofa
Fournisseurs de qualité sélectionnés pour Ketohexokinase Protéines (KHK)
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