anti-Killer Cell Immunoglobulin Like Receptor 2DS1 Anticorps

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.

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Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1) profil antigène

Profil protéine

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Gene names and symbols associated with KIR2DS1

  • killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 (KIR2DS1) anticorps
  • CD158a anticorps
  • CD158H anticorps
  • p50.1 anticorps

Protein level used designations for KIR2DS1

CD158 antigen-like family member H , KIR2DL1-KIR2DS1 , MHC class I NK cell receptor Eb6 ActI , killer cell immunoglobulin-like receptor 2DS1 , killer cell immunoglobulin-like receptor KIRDS1 , killer-cell immunoglobulin-like receptor

GENE ID SPECIES
3806 Homo sapiens
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