Profil protéine

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Gene names and symbols associated with KIR2DS2

• killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 (KIR2DS2) anticorps

• 183ActI anticorps
• CD158b anticorps
• CD158J anticorps
• cl-49 anticorps
• NKAT5 anticorps

Protein level used designations for KIR2DS2

1060P11.9.2 , CD158 antigen-like family member J , MHC class I NK cell receptor , NK receptor 183 ActI , NKAT-5 , killer cell immunoglobulin-like receptor 2DS2 , killer-cell Ig-like receptor , killer-cell immunoglobulin-like receptor two domains short tail 2 protein , natural killer associated transcript 5 , natural killer cell inhibitory receptor , natural killer-associated transcript 5 , p58 KIR , p58 NK receptor CL-49 , p58 killer cell inhibitory receptor KIR-K7a , p58 natural killer cell receptor clone CL-49