Killer Cell Lectin-Like Receptor Subfamily C, Member 2 (KLRC2) Kits ELISA

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. De plus, nous expédions Killer Cell Lectin-Like Receptor Subfamily C, Member 2 Anticorps (41) et Killer Cell Lectin-Like Receptor Subfamily C, Member 2 Protéines (11) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
KLRC2 3822 P26717
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
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Plus Kits ELISA pour Killer Cell Lectin-Like Receptor Subfamily C, Member 2 partenaires d'interaction

Human Killer Cell Lectin-Like Receptor Subfamily C, Member 2 (KLRC2) interaction partners

  1. From all variants, only the NKG2Cwt/wt genotype was significantly associated with freedom from human cytomegalovirus viremia (P = .0002) and disease (P = .02), compared with the NKG2Cwt/del genotype. Thus, lung transplant recipients expressing the homozygous NKG2C wild type seem to have a selective advantage in human cytomegalovirus defense.

  2. a 16kb deletion encompassing the NKG2C gene is associated with lower carotid intimal media thickness values and higher humoral and T-cell responses to cytomegalovirus in renal transplant recipients

  3. the data of this study extend the characterization of adaptive NK cell subsets that differentiate in response to human Cytomegalovirus, supporting a relationship between their distribution and NKG2C copy number

  4. The new method offers the potential to use SNP arrays from genome wide association studies to study the frequency of KLRC2 deletion in other populations and its association with other diseases

  5. Assessment of NK cell repertoires in 60 NKG2C(-/-) donors revealed a broad range of NK cell populations displaying characteristic footprints of adaptive NK cells, including a terminally differentiated phenotype, functional reprogramming, and epigenetic remodeling of the interferon (IFN)-gamma promoter.

  6. HLA-E regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire

  7. genetic polymorphism is not associated with nasopharyngeal carcinoma in China

  8. Data suggest the proinflammatory potential of NKG2C(bright) NK cells.

  9. lack of expression of NKG2C may be associated with altered control of human cytomegalovirus infection in childhood

  10. No difference in the prevalence of NKG2C deletion was observed.

  11. NKG2C receptor deletion and a functional polymorphism in its ligand HLA-E may play a role in psoriasis susceptibility

  12. NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus.

  13. NKG2Cnull does not seem to constitute a risk factor for HPV-induced cervical lesions.

  14. NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus.

  15. coexpression of killer cell Ig-like receptor (KIR) and NKG2C on expanded NK cell subsets could be related to a functional contribution of KIR in cytomegalovirus infection

  16. NKG2Chi CD57hi natural killer cells are highly responsive to human cytomegalovirus-infected macrophages only in the presence of HCMV-specific antibodies, whereas they are functionally poor effectors of natural cytotoxicity.

  17. The increased expression of NKG2C in HIV patients indicate that NKG2C is important in the defense against HIV infection and progression.

  18. A significantly elevated proportion of ex vivo peripheral blood CD4 T cells, but not CD8 T cells or natural killer (NK) cells, from multiple sclerosis patients express NKG2C, which contributes to tissue injury.

  19. HCMV-infected NKG2C(+/+) children displayed higher absolute numbers of NKG2A(+) and total NK cells than NKG2C(+/-) individuals.

  20. Data indicate that the increased frequency of CD8(+) effector-memory T cells with activating NKR KIR2DS4, NKG2C and NKG2D, and cytotoxicity toward hematopoietic cell lines suggests involvement in bone marrow failure and clonal expansion in PNH.

Killer Cell Lectin-Like Receptor Subfamily C, Member 2 (KLRC2) profil antigène

Antigen Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.

Gene names and symbols associated with KLRC2

  • killer cell lectin like receptor C2 (KLRC2) anticorps
  • killer cell lectin-like receptor subfamily C, member 2 (KLRC2) anticorps
  • CD159c anticorps
  • NKG2-C anticorps
  • NKG2C anticorps

Protein level used designations for KLRC2

CD159 antigen-like family member C , NK cell receptor C , NKG2-C type II integral membrane protein , NKG2-C-activating NK receptor , NKG2-FE

GENE ID SPECIES
3822 Homo sapiens
100125588 Macaca mulatta
450132 Pan troglodytes
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