Kinase Suppressor of Ras 2 (KSR2) Kits ELISA

Location-regulated scaffold connecting MEK to RAF. De plus, nous expédions Kinase Suppressor of Ras 2 Anticorps (87) et Kinase Suppressor of Ras 2 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
KSR2 283455 Q6VAB6
KSR2 333050  
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Top Kinase Suppressor of Ras 2 Kits ELISA sur anticorps-enligne.fr

Showing 3 out of 9 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 46.9 pg/mL 78 pg/mL - 5000 pg/mL A typical standard curve 96 Tests 13 to 16 Days
$641.23
Détails
Souris 0.094 ng/mL 0.15 ng/mL - 10 ng/mL A typical standard curve 96 Tests 13 to 16 Days
$641.23
Détails
Humain
  96 Tests 2 to 3 Days
$380.00
Détails

Plus Kits ELISA pour Kinase Suppressor of Ras 2 partenaires d'interaction

Human Kinase Suppressor of Ras 2 (KSR2) interaction partners

  1. These observations suggest that, in the brain, KSR2 regulates energy balance via control of feeding behavior and adaptive thermogenesis, while a second KSR2-dependent mechanism, functioning through one or more other tissues, modulates sensitivity to leptin and activators of the energy sensor AMPK.

  2. A pleiotropic effect of KSR2-rs7973260 was found on the risk of metabolic syndrome, severe hypertriglyceridemia, and diabetes.

  3. KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization.

  4. Study explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 that disrupt signaling through the Raf-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells.

  5. study demonstrated that miR-31 upregulated IL-2 expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation

  6. The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis.

  7. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans

  8. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells.

  9. hKSR-2, a new member of the KSR family, negatively regulates Cot-mediated MAP kinase and NF-kappaB pathway signaling

  10. We find that while hKSR-2 blocks MEKK3 activation, it has little to no effect on other members of the MAP3K family, including MEKK4, TAK1, and Ras-Raf, suggesting that its effects are selective.

  11. These results demonstrate that kinase suppressor of Ras 2 is a direct target of 1,25-dihydroxyvitamin D(3)in HL60 cells, and is required for optimal monocytic differentiation.

  12. KSR-2 may act as a scaffold protein similar as KSR-1 to mediate the MAPK core (RAF-MEK-ERK) signaling but with a distinct RAF isoform specificity; KSR-2 may only mediate the A-RAF signaling while KSR-1 transduces signals only from c-RAF.

Mouse (Murine) Kinase Suppressor of Ras 2 (KSR2) interaction partners

  1. These data indicate that KSR2 functions in a cell non-autonomous fashion to regulate GH-stimulated IGF-1 expression in the liver of neonatal mice, which plays a key role in the development of body length.

  2. KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization.

  3. KSR2 is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways

  4. The metabolic phenotype of KSR2 heterozygous (KSR2(+/minus;)) and KSR2(-/-) mice suggests that human KSR2 variants may contribute to a similar phenotype linked to human chromosome 12q24

  5. KSR2 regulates AMPK-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line.

  6. The protein phosphatase calcineurin selectively interacts with KSR2 and KSR2 uniquely contributes to Ca2+-mediated ERK signaling.

Kinase Suppressor of Ras 2 (KSR2) profil antigène

Antigen Summary

Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Gene names and symbols associated with KSR2

  • kinase suppressor of ras 2 (KSR2) anticorps
  • kinase suppressor of ras 2 (Ksr2) anticorps

Protein level used designations for KSR2

kinase suppressor of Ras 2

GENE ID SPECIES
283455 Homo sapiens
333050 Mus musculus
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