Kinesin Family Member 11 (KIF11) Kits ELISA

KIF11 encodes a motor protein that belongs to the kinesin-like protein family. De plus, nous expédions KIF11 Anticorps (135) et KIF11 Protéines (4) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
KIF11 3832 P52732
Anti-Souris KIF11 KIF11 16551 Q6P9P6
Anti-Rat KIF11 KIF11 171304  
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  2 x 96 Tests 2 to 3 Days

Plus Kits ELISA pour KIF11 partenaires d'interaction

Human Kinesin Family Member 11 (KIF11) interaction partners

  1. The results show that at metaphase both Eg5-EGFP and TPX2-EGFP are enriched toward spindle poles, but only TPX2-EGFP is enriched relative to microtubules. Eg5-EGFP and TPX2-EGFP show distinct localization patterns in anaphase, with Eg5-EGFP relocalizing to the midzone earlier than TPX2-EGFP.

  2. both KIF15 and the C-terminal-truncated KIF11 contributes to the S-trityl L-cysteine resistance of the U-2OS derived cells

  3. Levels of Kif11 were significantly higher in clear cell renal cell carcinoma (CCRCC) tissues compared with non-cancerous tissues. Expression of Kif11 protein was significantly associated with clinicopathologial parameters, including nuclear grade and TNM stage. High Kif11 expression, nuclear grade and TNM stage were independent factors to predict poor prognosis in patients with CCRCC.

  4. VPS28, an ESCRT-I protein, interacts with Gbetagamma and Eg5-TPX2. VPS28 organizes Aster Microtubules via Gbetagamma. VPS28 recruits Eg5 and TPX2 to regulate mitotic spindle bipolarity.

  5. The mitotic spindle is chiral. Chirality is evident from the finding that microtubule bundles in human spindles follow a left-handed helical path, which cannot be explained by forces but rather by torques. Kinesin-5 (Kif11/Eg5) inactivation abolishes spindle chirality.

  6. PP2A controls mitotic exit through EG5 dephosphorylation.

  7. These data demonstrate the functional interplay between PTEN and EG5 in controlling mitotic spindle structure and chromosome behaviour during mitosis.

  8. the RNF20/40 complex, a major ubiquitin ligase catalysing histone H2B monoubiquitination, interacts with the motor protein Eg5 during mitosis and participates in spindle assembly.

  9. Stability of protein-ligand complexes were analyzed using molecular dynamic simulations. Our studies suggest that pyridazine analogs have good MDCK, permeability properties and high binding affinity to the human Eg5.

  10. These results illustrate how a posttranslational modification of a kinesin can be used to fine tune motor behavior to meet specific physiological needs.

  11. Immunohistochemical analysis demonstrated that KIF11 was expressed in 64 of 99 (64.6%) oral cancer tissues but not in healthy oral epithelia. Strong KIF11 expression was significantly associated with poor prognosis among oral cancer patients (P=0.034), and multivariate analysis confirmed its independent prognostic value.

  12. Results identified 7 novel KIF11 mutations during the screening of 142 patients with familial exudative vitreoretinopathy (FEVR), and further confirmed that KIF11 is causative of FEVR in an autosomal dominant manner.

  13. results demonstrate that Eg5 is phosphorylated in cultured cells by Src family kinases (SFKs) at three sites in the motor head: Y125, Y211, and Y231. Mutation of these sites diminishes motor activity in vitro, and replacement of endogenous Eg5 with phosphomimetic Y211 in LLC-Pk1 cells results in monopolar spindles, consistent with loss of Eg5 activity.

  14. Results show that KIF11 mRNA expression was upregulated in prostate cancer tissues and associated with aggressive characteristics.

  15. Eg5 is overexpressed in the livers of the hepatocellular carcinoma patients and is predictive of poor prognosis.

  16. The data suggested that Eg5 may be identified as a novel prognostic biomarker and targeting Eg5 seems to be a novel strategy for LSCC treatment.

  17. Progressive retinal degeneration in KIF11-related retinopathy indicates a role for KIF11 not only in ocular development but also in maintaining retinal morphology and function. The remarkable variability of the ocular phenotype suggests four different types of retinopathy which may overlap.

  18. Among the detected mutations, LRP5 accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (3/31, 9.7%), FZD4 (2/31, 6.5%), TSPAN12 (1/31, 3.2%), and KIF11 (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  19. Data show that the kinesin 5 (Eg5) binding time has less sensitivity on MCF7 as compared to bovine brain microtubules.

  20. mixing of Eg5 and MTs produced a range of spatiotemporal dynamics

Pig (Porcine) Kinesin Family Member 11 (KIF11) interaction partners

  1. Data suggest that poleward transport of TPX2, which requires dynein and Eg5, down-regulates its microtubule nucleating activity near kinetochores and links microtubules to dynein for incorporation into the spindle.

Mouse (Murine) Kinesin Family Member 11 (KIF11) interaction partners

  1. Kif11 regulates excitatory synaptic transmission. Kif11 knockdown enhanced dendritic arborization, synapse number, expression of synaptophysin and Piccolo in vitro.

  2. NEK7 regulates dendrite morphogenesis in vitro and in vivo. NEK7 kinase activity is required for dendrite growth and branching, as well as spine formation and morphology. NEK7 regulates these processes in part through phosphorylation of the kinesin Eg5/KIF11, promoting its accumulation on microtubules in distal dendrites.

  3. that Pten, through the Dlg1-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes

  4. Fbxo30-Eg5 interaction as a critical checkpoint in mammopoiesis.

  5. Data show that the STIM1 Ksp (Eg5)-cre knockout mice produced more urine compared to control.

  6. Data suggest that amyloid-beta (here, Abeta 1-42) induces acute and chronic synaptic dysfunction in part through inhibition of Eg5 (kinesin-5) in hippocampal neurons.

  7. Disruption of the in vivo interaction of KIF11 with ZBP1 delocalizes beta-actin mRNA and affects cell migration.

  8. Its inhibition reduces neutrotrophin and transmitter receptor function.

  9. These results suggest that 4-(N-(2-(N-acetylcysteine-S-yl) acetyl) amino)-4'- (N-(2-(N-(triphenylmethyl)amino)acetyl)amino)azobenzene could be used as photochromic inhibitor of Eg5 to achieve photocontrol of living cells.

  10. incorporation of photochromic molecules into the key region of loop L5 facilitates the photocontrol of the function of kinesin Eg5.

  11. Finally, when kinesin spindle protein (KSP) siRNA was encapsulated in lipid nanoparticles containing a modest amount of PEG, the proliferation of endothelial cells was inhibited due to the efficient knock down of KSP mRNA.

  12. These results show that intratumoral electro-transfer of siRNA is feasible and kinesin spindle protein (KSP)-specific siRNA may provide a novel strategy for therapeutic intervention.

  13. observations explain the poleward accumulation of Eg5 in early mitosis and its redistribution in anaphase. Inhibition of dynein blocked Eg5 movement on microtubules, whereas depletion of the Eg5-binding protein TPX2 resulted in end-directed Eg5 movement.

  14. Observations further support the conclusion that Eg5 is essential for cell division early in mouse development.

  15. Results indicate that Eg5 overexpression disrupts the unique balance of forces associated with normal spindle assembly and function, and thereby leads to the development of spindle defects, genetic instability, and tumors.

  16. Eg5 is essential during early mouse development and cannot be compensated by another molecular motor.

Cow (Bovine) Kinesin Family Member 11 (KIF11) interaction partners

  1. Data show that the kinesin 5 (Eg5) binding time has less sensitivity on MCF7 as compared to bovine brain microtubules.

KIF11 profil antigène

Antigen Summary

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.

Gene names and symbols associated with KIF11

  • P-loop containing nucleoside triphosphate hydrolases superfamily protein (AT2G36200) anticorps
  • kinesin family member 11 (kif11) anticorps
  • kinesin family member 11 (KIF11) anticorps
  • kinesin family member 11 (Kif11) anticorps
  • DDBDRAFT_0189194 anticorps
  • DDBDRAFT_0201556 anticorps
  • DDB_0189194 anticorps
  • DDB_0201556 anticorps
  • Eg5 anticorps
  • F2H17.19 anticorps
  • F2H17_19 anticorps
  • HKSP anticorps
  • Kif8 anticorps
  • Kifl1 anticorps
  • Knsl1 anticorps
  • MCLMR anticorps
  • TRIP5 anticorps

Protein level used designations for KIF11

TR-interacting protein 5 , TRIP-5 , kinesin-like protein 1 , kinesin-like protein KIF11 , kinesin-like spindle protein HKSP , kinesin-related motor protein Eg5 , thyroid receptor-interacting protein 5 , kinesin 11 , kinesin-like 1

818192 Arabidopsis thaliana
8627935 Dictyostelium discoideum AX4
3832 Homo sapiens
100526080 Sus scrofa
16551 Mus musculus
171304 Rattus norvegicus
423809 Gallus gallus
477769 Canis lupus familiaris
508467 Bos taurus
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