anti-LEM Domain Containing 3 (LEMD3) Anticorps

This locus encodes a LEM domain-containing protein. De plus, nous expédions LEM Domain Containing 3 Protéines (3) et LEM Domain Containing 3 Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
LEMD3 23592 Q9Y2U8
LEMD3 380664 Q9WU40
LEMD3 680066  
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Top anti-LEM Domain Containing 3 Anticorps sur anticorps-enligne.fr

Showing 10 out of 20 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Chien Souris Inconjugué FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Détails
Chien Souris Inconjugué FACS, IF, WB 100 μL 11 to 14 Days
$522.50
Détails
Humain Souris Inconjugué FACS, IF, IP, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. Immunohistochemical staining of paraffin-embedded liver tissue using anti-LEMD3mouse monoclonal antibody. (ABIN2453228, Dilution 1:50) 0.1 mL 2 to 3 Days
$462.00
Détails
Humain Lapin Inconjugué ELISA, IF, IHC, IHC (p), WB Anti-LEMD3 / MAN1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$616.00
Détails
Humain Souris Inconjugué FACS, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. Flow cytometric Analysis of Hela cells, using anti-LEMD3 antibody (ABIN2453808), (Red), compared to a nonspecific negative control antibody, (Blue). 0.1 mL 2 to 3 Days
$462.00
Détails
Humain Lapin Inconjugué EIA, IF, IHC (p), WB   0.1 mg 4 to 8 Days
$522.50
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Immunohistochemical analysis of LEMD3 in human colon tissue with LEMD3 polyclonal antibody  at 2.5 ug/mL. Western blot analysis of LEMD3 in human colon tissue with LEMD3 polyclonal antibody  at 1 ug/mL. 100 μg 11 to 12 Days
$356.00
Détails
Humain Souris Inconjugué IF, IP, WB Anti-LEMD3 mouse monoclonal antibody (ABIN2453229) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEMD3 (RC212759). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. 0.1 mL 2 to 3 Days
$462.00
Détails
Humain Souris Inconjugué FACS, IF, IP, IHC, WB Immunohistochemical staining of paraffin-embedded breast tissue using anti-LEMD3 mouse monoclonal antibody. (ABIN2453231, Dilution 1:50) Immunohistochemical staining of paraffin-embedded colon tissue using anti-LEMD3mouse monoclonal antibody. (ABIN2453231, Dilution 1:50) 0.1 mL 2 to 3 Days
$462.00
Détails
Humain Souris Inconjugué FACS, IF, IP, WB Anti-LEMD3 mouse monoclonal antibody (ABIN2453230) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEMD3 (RC212759). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. 0.1 mL 2 to 3 Days
$482.90
Détails

anti-LEM Domain Containing 3 Anticorps mieux référencés

  1. Human Monoclonal LEMD3 Primary Antibody pour FACS, IF - ABIN2724623 : Bermeo, Al-Saedi, Kassem, Vidal, Duque: The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation. dans Journal of cellular biochemistry 2018 (PubMed)

Plus d’anticorps contre LEM Domain Containing 3 partenaires d’interaction

Human LEM Domain Containing 3 (LEMD3) interaction partners

  1. Here we describe the unusual case of a 60-year-old woman with isolated nevus elasticus and a mutation in the LEMD3 (LEM Domain Containing 3) gene.

  2. analysis of the structural basis for R-SMAD recognition by MAN1 using SMAD2-MAN1 and SMAD1-MAN1 complex structures

  3. LEMD3 is cleaved by PPM1a into fragments that enter the cytosol to bind SMAD2 and SMAD3, thereby antagonizing signaling initiated by stiffness-triggered activity of TGFbeta.

  4. studies demonstrated that lower levels of MAN1 in differentiating MSC are associated with higher osteogenesis and lower adipogenesis. High levels of MAN1 only affected adipogenesis.

  5. LAMD3 Y871X mutation is associated with osteopoikilosis.

  6. Letter/Case-Report: novel frameshift mutation in RNA recognition motif of LEMD3 in patient with Buschke-Ollendorff syndrome.

  7. A novel mutation in LEMD3 splice site results in Buschke-Ollendorff syndrome.

  8. Data indicate that the inner nuclear membrane protein MAN1 directly binds the transcription activator BMAL1 promoter and enhances its transcription.

  9. a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A.

  10. The absence of direct binding of BAF to MAN1-C eliminates disruption of this interaction as the cause of the premature aging phenotype.

  11. Genetic analyses of three generations of a family with Buschke-Ollendorff syndrome having a variable phenotype showed a novel c.2203C>T nonsense mutation at the LEMD3 locus. The mutation induced a change in the 735 arginine codon to a stop codon.

  12. Buschke-Ollendorff syndrome in a three-generation family: influence of a novel LEMD3 mutation to tropoelastin expression.

  13. We found a novel c.2203C > T (p.R735X) mutation in exon 9 of LEMD3, resulting in a premature stop codon at amino acid position 735.

  14. Absence of LEMD3 mutation in the exons and splice sites of a family with BOS suggests that there is genetic heterogeneity for this disorder.

  15. The C-terminal domain of human MAN1 binds to Smad2 and Smad3 and antagonizes signaling by transforming growth factor-beta

  16. Overexpression results in inhibition of R-Smad phosphorylation, heterodimerization with Smad4, and nuclear translocation

  17. Data describe the direct binding of the nuclear membrane protein MAN1 to emerin in vitro.

  18. germline LEMD3 mutations are rare in sporadic patients with isolated melorheostosis

  19. MAN1 binds simultaneously to R-Smads and their targeted DNA sequences

  20. novel mutation associated with familial cutaneous collagenomas

Mouse (Murine) LEM Domain Containing 3 (LEMD3) interaction partners

  1. a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A.

  2. the heterozygous Lemd3 gene-trapped mouse is not a good model to study osteopoikilosis and the Buschke-Ollendorff syndrome.

  3. In Man1-deficient embryos, the expression of Tgfb1 is upregulated and Smad2/3 signaling is abnormally activated, resulting in increased extracellular matrix deposition, a hallmark of the resolution phase of angiogenesis.

  4. The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac.

  5. Man1 regulates left-right asymmetry by controlling Nodal signaling in a node-independent manner

Pig (Porcine) LEM Domain Containing 3 (LEMD3) interaction partners

  1. Genome-wide analysis combined with linkage results revealed LEMD3 and WIF1 as the candidates for porcine ear size.

Xenopus laevis LEM Domain Containing 3 (LEMD3) interaction partners

  1. LEM proteins, involved in signalling essential for organ development during early embryogenesis and suggests that loss of MAN1 may cause muscle and retina specific diseases

LEM Domain Containing 3 (LEMD3) profil antigène

Profil protéine

This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.

Gene names and symbols associated with LEMD3

  • LEM domain containing 3 (LEMD3) anticorps
  • LEM domain containing 3 (Lemd3) anticorps
  • LEM domain containing 3 (lemd3) anticorps
  • LEM domain containing 3 S homeolog (lemd3.S) anticorps
  • AI316861 anticorps
  • im:7158446 anticorps
  • lemd3 anticorps
  • man1 anticorps
  • RGD1561001 anticorps
  • sane anticorps
  • si:dkey-6a5.6 anticorps
  • wu:fb34b12 anticorps
  • xman1 anticorps

Protein level used designations for LEMD3

LEM domain-containing protein 3 , inner nuclear membrane protein Man1 , integral inner nuclear membrane protein , integral inner nuclear membrane protein MAN1 , LEM domain containing 3 , Smad1 antagonistic effector , LEM domain containing 3 S homeolog , nuclear membrane protein XMAN1

GENE ID SPECIES
23592 Homo sapiens
380664 Mus musculus
417832 Gallus gallus
452050 Pan troglodytes
530659 Bos taurus
558474 Danio rerio
608380 Canis lupus familiaris
680066 Rattus norvegicus
717597 Macaca mulatta
100038042 Xenopus (Silurana) tropicalis
100079476 Ornithorhynchus anatinus
100346960 Oryctolagus cuniculus
100402143 Callithrix jacchus
100441107 Pongo abelii
100511508 Sus scrofa
100553511 Anolis carolinensis
398582 Xenopus laevis
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