LIM and SH3 Protein 1 (LASP1) Kits ELISA

LASP1 encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. De plus, nous expédions LASP1 Anticorps (114) et LASP1 Protéines (13) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
LASP1 3927 Q14847
LASP1 16796 Q61792
LASP1 29278 Q99MZ8
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.065 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days
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  96 Tests 15 to 18 Days

Plus Kits ELISA pour LASP1 partenaires d'interaction

Human LIM and SH3 Protein 1 (LASP1) interaction partners

  1. HBX contributes to LASP-1 expression via the activation of c-Jun to increase the promoter activity of LASP-1.

  2. LASP1 enhances cell proliferation, plate cloning, metastasis and invasion, G2/M phase transition of cell cycle, promotes lung metastasis in nude mice and docetaxel resistance of oral squamous cell carcinoma cell line HN30.

  3. Low expression of microRNA-203 could promote the invasion and inhibit apoptosis of laryngeal cancer cells viainhibiting LASP1. microRNA-203 and LASP1 both play a very important role in the development of laryngeal cancer

  4. LASP1 activates the PI3K/AKT signaling pathway and is downregulated by miR-377-3p during glioma progression.

  5. LASP1 may function as an oncogene in glioblastoma and regulate cell proliferation and chemosensitivity in a PI3K/AKT-dependent mechanism.

  6. A positive correlation was found between the expression of LASP1 and COPS5 while a negative correlation existed between 14-3-3sigma and COPS5/LASP1 in most CRC samples.

  7. Data shows that LASP1 is significantly upregulated in breast cancer tissues and cell lines, and its upregulation significantly associated with disease progression. Also, LASP1 was identified as a target gene of miR-133a, and its expression negatively regulated by miR-133a in breast cancer cells.

  8. An in vitro study showed that overexpression of miR-133b inhibited the proliferation, migration, and invasion of HepG2 and Hep3B cells. Similarly, knockdown of LASP1 reduced HepG2 and Hep3B cell proliferation, migration, and invasion.

  9. Findings indicated that LASP-1, as a downstream target of SOX9, may act as a novel biomarker for lung cancer and plays an important role in cell proliferation, migration, and invasion.

  10. miR-203a-3p suppresses tumor growth and metastasis through targeting LASP1 in NPC.

  11. LASP1 silencing elicited effects similar to miR-326 overexpression on HCC cells.

  12. A combination of low 14-3-3sigma and high LASP1 expression shows a worse trend with overall survival of colorectal cancer patients.

  13. Furthermore, we identify flotillin-1 (FLOT1) and histone H1 as downstream factors for cytoplasmic and nuclear pathway of S100A11, which are required for LASP1-S100A11 axis-mediated epithelial-mesenchymal transition and colorectal cancer progression.

  14. Overexpression of LASP-1 in thyroid cancer tissues.LASP-1 role in thyroid cancer cell proliferation and invasion.LASP-1 is an oncogene.

  15. Study found LASP1 to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown in esophageal squamous cell carcinoma.

  16. Data indicate that LIM and SH3 protein 1 (LASP1) is a direct target of miR-145.

  17. LASP1 enhances the expression and secretion of MMPs, favoring breast cancer cell migration and invasiveness.

  18. miR-218 contributes to PE by targeting LASP1 to inhibit trophoblast invasion

  19. The correlation between LIM and SH3 domain-containing protein expression levels in cancer and the poor outcome and metastatic behavior of tumors denotes the clinical significance of this protein and hints its potential value as a new cancer prognostic or even diagnostic biomarker

  20. LASP-1 contributes to the formation and progression of prostate cancer through a NF-kappaappa B pathway.

Mouse (Murine) LIM and SH3 Protein 1 (LASP1) interaction partners

  1. Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC.

  2. Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.

  3. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions

  4. Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM proteins.

  5. Data suggest that there are no functional differences between human and mouse LASP-1.

  6. The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.

  7. role of Lasp1 in chondrocyte differentiation during cartilage to bone transition

LASP1 profil antigène

Antigen Summary

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.

Gene names and symbols associated with LASP1

  • LIM and SH3 protein 1 (lasp1) anticorps
  • LIM and SH3 protein 1 L homeolog (lasp1.L) anticorps
  • LIM and SH3 protein 1 (LASP1) anticorps
  • LIM and SH3 protein 1 (Lasp1) anticorps
  • AA408629 anticorps
  • Def-4 anticorps
  • fb92f05 anticorps
  • lasp-1 anticorps
  • LASP1 anticorps
  • MGC53336 anticorps
  • MGC89667 anticorps
  • mln50 anticorps
  • SH3P6 anticorps
  • Tg(Col1a1-lacZ)1Ngma anticorps
  • wu:fb92f05 anticorps
  • zgc:77542 anticorps

Protein level used designations for LASP1

LIM and SH3 domain protein 1 , LIM and SH3 protein 1 , lasp1 protein , metastatic lymph node gene 50 protein , LASP-1 , MLN 50 , Tg(11Col1a1)NG , 40 kDa phosphoprotein , phosphoprotein Lasp-1 , pp40

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694950 Macaca mulatta
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16796 Mus musculus
29278 Rattus norvegicus
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323216 Danio rerio
495167 Xenopus laevis
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100009568 Oryctolagus cuniculus
100173670 Pongo abelii
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