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Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. De plus, nous expédions Late Endosomal/lysosomal Adaptor, MAPK and MTOR Activator 1 Anticorps (24) et Late Endosomal/lysosomal Adaptor, MAPK and MTOR Activator 1 Protéines (6) et beaucoup plus de produits pour cette protéine.
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In vitro reconstitution and experiments with site-directed mutagenesis defined the physiological importance of LAMTOR1 in assembling the remaining components to ensure fidelity of mTORC1 signaling.
LAMTOR1 is a negative regulator of Arl8b (Montrer ARL8B Kits ELISA)- and BORC-dependent late endosomal positioning.
Study found that NF1 (Montrer NF1 Kits ELISA) negatively regulates mTOR (Montrer FRAP1 Kits ELISA) signaling in a LAMTOR1-dependent manner. In addition, the cell growth and survival of NF1 (Montrer NF1 Kits ELISA)-deficient cells have become dependent on hyperactivation of the mTOR (Montrer FRAP1 Kits ELISA) pathway, and the tumorigenic properties of these cells have become dependent on LAMTOR1.
Western blot experiments designed to detect flotillin 2 (Montrer FLOT2 Kits ELISA), TMEM256, Rab3B (Montrer RAB3B Kits ELISA) and LAMTOR1 showed that the level of these proteins was higher in urinary exosomes from prostate cancer patients compared to healthy males
Data suggest that ablation of p18/LAMTOR1 suppresses starvation-induced cell death by stimulating autophagy through modulation of p27(kip1 (Montrer CDKN1B Kits ELISA)) activity.
LAMTOR1 expression affects the tuning of lysosomal activation that can lead to p53 (Montrer TP53 Kits ELISA)-dependent apoptosis through excessive catabolism.
A p27(kip1 (Montrer CDKN1B Kits ELISA))-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA (Montrer RHOA Kits ELISA) and RhoC (Montrer RHOC Kits ELISA).
MT1-MMP (Montrer MMP14 Kits ELISA)-associated protein p27RF-Rho binds p27(kip1 (Montrer CDKN1B Kits ELISA)) and prevents p27(kip1 (Montrer CDKN1B Kits ELISA)) from binding to RhoA (Montrer RHOA Kits ELISA). [p27RF-Rho]
A complex encoded by the MAPKSP1 (Montrer MAPKSP1 Kits ELISA), ROBLD3 (Montrer LAMTOR2 Kits ELISA), and c11orf59 genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
Studies in rat and mic (Montrer CDKN2C Kits ELISA)e, identified the rat p18 protein a (Montrer MAP2K1 Kits ELISA)s an (Montrer EPHB2 Kits ELISA) endosomal membrane anchoring protein which interacts with MEK1 scaffold (Montrer MAP2K1 Kits ELISA)p14/ (Montrer EPHB2 Kits ELISA)MP1 and mobilizes them to late endosome.
this study shows that polarization of Th17 cells, but not Th1 (Montrer HAND1 Kits ELISA) and Th2 cells, diminishes following the loss of Lamtor1; Lamtor1-knockout mice are resistant to experimental autoimmune encephalomyelitis
Findings suggested that the p18 (Montrer CDKN2C Kits ELISA)-associated pathways, mTORC1 and/or MAPK (Montrer MAPK1 Kits ELISA) pathways, are involved in promoting functional interactions between lysosomes and target organelles to regulate lysosome-mediated catabolic processes.
These results suggest that the p18 (Montrer CDKN2C Kits ELISA)-mTORC1 pathway plays crucial roles in the late stages of lysosomal maturation, potentially in late endosome-lysosome fusion, which is required for processing of various macromolecules.
analysis of interactions between kinase scaffold MP1 (Montrer MAPKSP1 Kits ELISA)/p14 (Montrer PCOLCE Kits ELISA) and its endosomal anchoring protein p18 (Montrer CDKN2C Kits ELISA)
lipid raft adaptor p18 (Montrer CDKN2C Kits ELISA) is essential for anchoring the MEK (Montrer MDK Kits ELISA)-ERK (Montrer EPHB2 Kits ELISA) pathway to late endosomes, and shed new light on a role of endosomal MEK (Montrer MDK Kits ELISA)-ERK (Montrer EPHB2 Kits ELISA) pathway in controlling endosome dynamics.
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity).
late endosomal/lysosomal adaptor and MAPK and MTOR activator 1
, p27Kip1-releasing factor from RhoA
, ragulator complex protein LAMTOR1
, rhoA activator C11orf59 homolog
, RhoA activator C11orf59
, lipid raft adaptor protein p18
, p27kip1 releasing factor from RhoA
, protein associated with DRMs and endosomes
, ragulator complex protein PDRO
, RhoA activator C11orf59 homolog