anti-Lectin, Galactoside-Binding, Soluble, 7 (LGALS7) Anticorps

Human Lectin, Galactoside-Binding, Soluble, 7 (LGALS7) interaction partners

1. Herein, the authors first revealed that Galectin-7 was one of the Tid1-interacting client proteins. An inverse association of protein expression profile between Tid1 and Galectin-7 was determined in head and neck squamous cell carcinoma patients. Low Tid1 and high Galectin-7 expression predicted poor overall survival in head and neck squamous cell carcinoma.

2. We further demonstrated using the NMR-based hydrogen-deuterium exchange (HDX) that lactose binding increases the exchange rates of residues located on the opposite side of the ligand-binding pocket for hGal1 and hGal8(NTD), indicative of allostery. Additionally, lactose binding induces significant stabilisation of hGal8(CTD) across the entire domain

3. Increased O-linked N-Acetyl-glucosamine (O-GlcNAc) is responsible for reduced Gal-7 expression in cultured human keratinocytes exposed to high glucose environment.

4. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7.

5. Data suggest that evaluation of galectin-7 could help guide postsurgical management for non-metastatic clear cell renal cell carcinoma (ccRCC).

6. these findings reveal the existence of a positive self-amplification pathway that regulates intracellular gal-7 expression in breast and ovarian cancer cells.

7. Gal-7 re-expression affects the regulation of molecular networks in cervical cancer that are involved in diverse cancer hallmarks, such as metabolism, growth control, invasion and evasion of apoptosis

8. Measurement of scGal-7 content in tape-stripped samples was useful for the evaluation of the skin barrier function in dry skin conditions such as AD

9. It is a beta-galactose-binding animal lectin and known to be distributed throughout the body.

10. Data indicate that the galectin inhibitor specifically binds galectin-7 (hGal-7), disrupts the formation of homodimers, and inhibits the pro-apoptotic activity of hGal-7 on Jurkat T cells.

11. Galectin-7 regulates keratinocytes proliferation and differentiation through JNK1 pathway.

12. The assessment of a carbohydrate-recognition domain (CRD)-defective mutant form of gal-7 (R7S) showed that the ability of this protein to modulate apoptosis was independent of its CRD activity.

13. our study validates the clinical significance of gal-7 overexpression in ovarian cancer

14. Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.

15. Galectin-7 is produced by the premenstrual and menstrual endometrium, where it accumulates in menstrual fluid and likely acts as a paracrine factor to facilitate post-menstrual endometrial re-epithelialization.

16. Understanding how these dendrimeric compounds interact with hGal-7 would help in the design of new tools to investigate the recognition of carbohydrates by lectins.

17. galectin-7 is a potential predictive marker of chemotherapy and/or radiotherapy resistance in patients with oral squamous cell carcinoma

18. Results suggest that galectin-3, -4, -7 and -9 could be involved in the biology of inverted papillomas.

19. galectin-7 may have a role in amyloidogenesis of primary localized cutaneous amyloidosis

20. C/EBPbeta is an important mediator of galectin-7 gene activation in breast cancer cells

Mouse (Murine) Lectin, Galactoside-Binding, Soluble, 7 (LGALS7) interaction partners

1. Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.

2. Serum galectin-7 was not useful for predicting prognosis in threatened abortion

3. Diabetic mice model shows that increased O-linked N-Acetyl-glucosamine (O-GlcNAc) is responsible for reduced Gal-7 expression in keratinocytes exposed to high glucose environment.

4. The data suggest that gal-7 could potentiate the phenotype of HER-2 positive primary breast cancer.

5. results indicate that an excess of galectin-7 leads to a destabilisation of adherens junctions associated with defects in epidermal repair

6. Overexpression of galectin-7 increased the resistance of melanoma cells to apoptosis while inducing de novo egr-1 expression.

7. In cardiac transplantation galectin-7 relates to acute allograft rejection and T-cell responses possibly as an accelerant.

8. Extracellular superoxide dismutase plays a role not only as a reactive oxygen species scavenger, but also as a pro-apoptotic factor via COX-2/galectin-7 pathways in the epidermis.

9. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells.

10. Data show that high levels of galectin-7 expression in breast cancer cells drastically increased their ability to metastasize to lungs and bones, and were restricted to high-grade breast carcinomas.

11. Galectin-3 and galectin-7 play a role in corneal epithelial wound healing.

12. Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype.

13. Galectin-7 promotes maliganacy by upregulating MMP-9 gene expression.

14. A comparative profiling has been started in the mouse as a model organism, combining sequence analysis, expression patterns and structural features in the cases of the homodimeric galectins-1, -2 and -7.

15. demonstrates cell-type specificity and cycle-associated regulation for galectin-3 with increased presence in atretic preantral follicles and in late stages of luteolysis

16. These studies provide the first genetic evidence showing that galectin-7 can modulate keratinocyte apoptosis, proliferation, and migration during skin repair.

Pig (Porcine) Lectin, Galactoside-Binding, Soluble, 7 (LGALS7) interaction partners

1. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells.