anti-Leprecan Like Protein 1 (LEPREL1) Anticorps

LEPREL1 encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. De plus, nous expédions LEPREL1 Kits (4) et LEPREL1 Protéines (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
LEPREL1 210530 Q8CG71
LEPREL1 288016 Q4KLM6
LEPREL1 55214 Q8IVL5
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Top anti-LEPREL1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 26 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cells, using LEPREL1 antibody. 100 μL 11 to 13 Days
$366.77
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of NCI-H460 cells, using LEPREL1 antibody. 200 μL 12 to 14 Days
$438.90
Détails
Humain Lapin Inconjugué IHC, ELISA, WB   100 μL 11 to 14 Days
$390.50
Détails
Humain Lapin Inconjugué IHC (p) Immunohistochemical staining of human placenta with LEPREL1 polyclonal antibody  shows strong cytoplasmic positivity in trophoblastic cells and decidual cells at 1:50-1:200 dilution. 100 μL 11 to 12 Days
$577.33
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with LEPREL1 polyclonal antibody . Immunohistochemical staining of human skeletal muscle with LEPREL1 polyclonal antibody  shows strong cytoplasmic positivity in myocytes. 100 μL 11 to 12 Days
$577.33
Détails
Humain Lapin Inconjugué WB   100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué ELISA, WB   100 μL 11 to 13 Days
$335.04
Détails
Humain Lapin Biotin ELISA   100 μg 11 to 16 Days
$469.05
Détails
Humain Lapin FITC ELISA   100 μg 11 to 16 Days
$469.05
Détails
Humain Lapin HRP ELISA   100 μg 11 to 16 Days
$469.05
Détails

anti-LEPREL1 Anticorps mieux référencés

  1. Human Polyclonal LEPREL1 Primary Antibody pour IHC, IHC (p) - ABIN4330688 : Fernandes, Farnand, Traeger, Weis, Eyre: A role for prolyl 3-hydroxylase 2 in post-translational modification of fibril-forming collagens. dans The Journal of biological chemistry 2011 (PubMed)

Plus d’anticorps contre LEPREL1 partenaires d’interaction

Mouse (Murine) Leprecan Like Protein 1 (LEPREL1) interaction partners

  1. Altered collagen prolyl 3-hydroxylation is caused by loss of P3H2.

  2. prolyl 3-hydroxylation of type IV collagen by P3H2 has an important function preventing maternal platelet aggregation in response to the early developing embryo

  3. P3H2 is responsible for the hydroxylation of collagen IV, which has the highest 3-hydroxyproline content of all collagens. It is thus possible that P3H2 mutations may lead to a disease with changes in basement membranes.

  4. Study found that all 3 mouse Leprecan genes Lepre1, leprel1 and leprel2 are expressed in the notochord; additionally, they are expressed in dorsal root ganglia, limb buds, branchial arches, and developing kidneys.

  5. This report characterizes expression of the P3H1, P3H2 and P3H3 genes in embryonic and adult mice.

Human Leprecan Like Protein 1 (LEPREL1) interaction partners

  1. Data identified an enhancer region within the TP63/LEPREL1 locus containing genetic variants associated with bladder cancer risk.

  2. Recessive LEPREL1 mutations should be recognized as part of the differential diagnosis of lens subluxation.

  3. LEPREL1 plays an important role in eye development and homozygous loss-of-function mutation of this gene can cause severely high myopia and early-onset cataract.

  4. mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.

  5. High myopia is caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2.

  6. P3H2 has preferred substrate sequences among the classes of 3Hyp sites in clade A collagen chains

  7. P3H2 is responsible for the hydroxylation of collagen IV, which has the highest 3-hydroxyproline content of all collagens. It is thus possible that P3H2 mutations may lead to a disease with changes in basement membranes.

  8. The restriction of silencing in P3H2 to breast carcinomas, and its association with oestrogen-receptor-positive cases, suggests that P3H2 may be a breast-cancer-specific tumour suppressor.

LEPREL1 profil antigène

Profil protéine

This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with LEPREL1

  • prolyl 3-hydroxylase 2 (P3h2) anticorps
  • prolyl 3-hydroxylase 2 (P3H2) anticorps
  • 4832416N06 anticorps
  • AW553532 anticorps
  • MCVD anticorps
  • MLAT4 anticorps
  • P3H2 anticorps

Protein level used designations for LEPREL1

leprecan-like protein 1 , myxoid liposarcoma associated protein 4 , prolyl 3-hydroxylase 2 , myxoid liposarcoma-associated protein 4 , prolyl 3-hydroxylase 3

GENE ID SPECIES
210530 Mus musculus
288016 Rattus norvegicus
55214 Homo sapiens
414143 Gallus gallus
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