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LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR\; MIM 600946) and leptin receptor (OBR, or LEPR\; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]\; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010].. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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Transgenic mice expressing either human LEPROT or human LEPROTL1 displayed growth retardation, reduced plasma IGF1 levels, and impaired hepatic sensitivity to GH, as measured by STAT5 phosphorylation and Socs2 mRNA expression.
the increased expression of FGF21 during chronic undernutrition inhibits GH action on chondrocytes by activating LEPROT and LEPROTL1.
both LEPROT and LEPROTL1 expression were regulated in liver by physiologic and pathologic changes in glucose homeostasis
Results indicated that the positive effect of the T allele at the SCD gene on monounsaturated fatty acid and of the T allele at the LEPR gene on saturated fatty acid are maintained throughout the growing-finishing period, both in longissimus thoracis and subcutaneous fat.
LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR\; MIM 600946) and leptin receptor (OBR, or LEPR\; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007
DnaJ (Hsp40) homolog, subfamily C, member 6 , OB-R gene-related protein , leptin receptor gene related protein , leptin receptor gene-related protein , leptin receptor overlapping transcript protein , OB-receptor gene related protein (OB-RGRP)