anti-Leucine Carboxyl Methyltransferase 1 (LCMT1) Anticorps

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999. De plus, nous expédions Leucine Carboxyl Methyltransferase 1 Protéines (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
LCMT1 51451 Q9UIC8
LCMT1 30949  
LCMT1 361643 Q6P4Z6
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Top anti-Leucine Carboxyl Methyltransferase 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 69 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Souris Inconjugué FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Détails
Humain Souris Inconjugué IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Détails
Humain Souris Inconjugué FACS, IF, IHC, WB Anti-LCMT1 mouse monoclonal antibody (ABIN2454745) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LCMT1 (RC200018). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LCMT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LCMT1. 0.1 mL 2 to 3 Days
$462.00
Détails
Humain Souris Inconjugué FACS, WB 100 μL 11 to 14 Days
$522.50
Détails
Humain Souris Inconjugué FACS, IF, WB HEK293T cells transfected with either RC200018 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LCMT1 antibody (ABIN2454742), and then analyzed by flow cytometry. Anti-LCMT1 mouse monoclonal antibody (ABIN2454742) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LCMT1 (RC200018). 0.1 mL 2 to 3 Days
$462.00
Détails
Humain Souris Inconjugué IHC, WB Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-LCMT1 mouse monoclonal antibody. (ABIN2454743) HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LCMT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LCMT1. 0.1 mL 2 to 3 Days
$482.90
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Mouse cerebellum lysates probed with LCMT1 Polyclonal Antibody, unconjugated  at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 90 minutes at 37°C. 100 μL 3 to 7 Days
$317.90
Détails
Humain Lapin Inconjugué IP, WB Immunoprecipitation of LCMT1 transfected lysate using anti-LCMT1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with LCMT1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of LCMT1 expression in transfected 293T cell line by LCMT1 MaxPab polyclonal antibody.Lane 1: LCMT1 transfected lysate(38.40 KDa).Lane 2: Non-transfected lysate. 100 μL 11 to 12 Days
$425.71
Détails
Souris Souris Inconjugué WB   100 μg 11 to 14 Days
$771.83
Détails
Humain Lapin Inconjugué WB Western Blot analysis of LCMT1 expression in transfected 293T cell line by LCMT1 MaxPab polyclonal antibody.Lane 1: LCMT1 transfected lysate(38.40 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$425.71
Détails

anti-Leucine Carboxyl Methyltransferase 1 Anticorps mieux référencés

  1. Human Monoclonal LCMT1 Primary Antibody pour FACS, IF - ABIN2724546 : Tang, Qin, Wang, Liang, Cai, Mo, Huang, Liang, Wei, Ao, Xu, Liu, Xiao, Guo, Lu, Li: H2 O2 induces PP2A demethylation to downregulate mTORC1 signaling in HEK293 cells. dans Cell biology international 2018 (PubMed)

Plus d’anticorps contre Leucine Carboxyl Methyltransferase 1 partenaires d’interaction

Human Leucine Carboxyl Methyltransferase 1 (LCMT1) interaction partners

  1. We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK).

  2. LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  3. alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD.

  4. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  5. GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1

  6. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A

  7. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet) has been solved to a resolution of 2 A.

  8. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Mouse (Murine) Leucine Carboxyl Methyltransferase 1 (LCMT1) interaction partners

  1. Loss of Lcmt1 expression is associated with severe defects in fetal liver hematopoiesis.

  2. LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.

  3. In LCMT1 deficiency enzyme activity and methylation of PP2A are reduced in a coordinate fashion, suggesting that LCMT1 is the only PP2A methyltransferase.

  4. Enhanced expression of LCMT1 in cultured neuroblastoma cells, which increases endogenous methylated catalytic C subunit and Balpha levels, induces changes in F-actin organization.

  5. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Leucine Carboxyl Methyltransferase 1 (LCMT1) profil antigène

Profil protéine

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA\; MIM 176915) (De Baere et al., 1999

Gene names and symbols associated with LCMT1

  • leucine carboxyl methyltransferase 1 (LCMT1) anticorps
  • leucine carboxyl methyltransferase 1 (lcmt1) anticorps
  • leucine carboxyl methyltransferase 1 L homeolog (lcmt1.L) anticorps
  • leucine carboxyl methyltransferase 1 (ANI_1_2090074) anticorps
  • leucine carboxyl methyltransferase 1 (PTRG_02142) anticorps
  • leucine carboxyl methyltransferase 1 (MCYG_00360) anticorps
  • leucine carboxyl methyltransferase 1 (AOR_1_842194) anticorps
  • leucine carboxyl methyltransferase 1 (Tsp_08223) anticorps
  • leucine carboxyl methyltransferase 1 (Lcmt1) anticorps
  • AL033290 anticorps
  • Lcmt anticorps
  • LCMT-1 anticorps
  • MGC114784 anticorps
  • PPMT1 anticorps
  • zgc:101094 anticorps

Protein level used designations for LCMT1

leucine carboxyl methyltransferase 1 , [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 , protein phosphatase methyltransferase 1 , protein-leucine O-methyltransferase

GENE ID SPECIES
416565 Gallus gallus
447907 Danio rerio
467930 Pan troglodytes
548787 Xenopus (Silurana) tropicalis
608360 Canis lupus familiaris
734508 Xenopus laevis
4983025 Aspergillus niger CBS 513.88
6338383 Pyrenophora tritici-repentis Pt-1C-BFP
9225317 Arthroderma otae CBS 113480
10099666 Aspergillus oryzae RIB40
10906787 Trichinella spiralis
100196453 Salmo salar
100528205 Ictalurus punctatus
100606762 Nomascus leucogenys
51451 Homo sapiens
30949 Mus musculus
361643 Rattus norvegicus
618021 Bos taurus
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