anti-Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) Anticorps

LRSAM1 encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. De plus, nous expédions LRSAM1 Protéines (6) et LRSAM1 Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
LRSAM1 90678 Q6UWE0
LRSAM1 227738 Q80ZI6
LRSAM1    
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Top anti-LRSAM1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 63 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue reacted with LRSAM1 Antibody (N-term) followed which was peroxidase conjugated to the secondary antibody and   followed by DAB staining. Western blot analysis of LRSAM1 Antibody 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué IP, WB Immunoprecipitation of LRSAM1 transfected lysate using anti-LRSAM1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with LRSAM1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of LRSAM1 expression in transfected 293T cell line by LRSAM1 MaxPab polyclonal antibody.Lane 1: LRSAM1 transfected lysate(83.60 KDa).Lane 2: Non-transfected lysate. 100 μL 11 to 12 Days
$425.71
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of LRSAM1 using HT29 whole cell lysates Western blot analysis of extracts from rat muscle, using LRSAM1 Antibody. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cells, using LRSAM1 antibody. 100 μL 11 to 13 Days
$366.77
Détails
Humain Lapin Inconjugué WB LRSAM1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LRSAM1 expression in human liver. Western Blot analysis of LRSAM1 expression in transfected 293T cell line by LRSAM1 MaxPab polyclonal antibody.Lane 1: LRSAM1 transfected lysate(83.60 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$425.71
Détails
Humain Souris Inconjugué WB Western Blot analysis of LRSAM1 expression in transfected 293T cell line by LRSAM1 MaxPab polyclonal antibody.Lane 1: LRSAM1 transfected lysate(79.53 KDa).Lane 2: Non-transfected lysate. LRSAM1 MaxPab polyclonal antibody. Western Blot analysis of LRSAM1 expression in human liver. 50 μg 11 to 12 Days
$440.00
Détails
Souris Lapin Inconjugué IHC, ELISA, WB   200 μL 11 to 16 Days
$658.43
Détails
Humain Lapin Cy7 IF (p)   100 μL 14 to 21 Days
$416.90
Détails
Humain Lapin Cy5 IF (p)   100 μL 14 to 21 Days
$416.90
Détails
Humain Lapin Cy3 IF (p)   100 μL 14 to 21 Days
$416.90
Détails

anti-LRSAM1 Anticorps mieux référencés

  1. Human Polyclonal LRSAM1 Primary Antibody pour IHC, IHC (p) - ABIN4331719 : Bogdanik, Sleigh, Tian, Samuels, Bedard, Seburn, Burgess: Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease. dans Disease models & mechanisms 2013 (PubMed)

Plus d’anticorps contre LRSAM1 partenaires d’interaction

Human Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners

  1. We report a novel LRSAM1 mutation c.2021-2024del (p.E674VfsX11) in 4 members of a Chinese autosomal dominant Charcot-Marie-Tooth disease type 2 family

  2. The article systematically represents the molecular functions, nature and detailed characterization of LRSAM1 E3 ubiquitin ligase, which are linked to molecular mechanisms of neurodegeneration. (Review)

  3. Our study shows the potential function of mir-939 through regulating LRSAM1 in Hirschsprung's disease

  4. We identified a novel LRSAM1 missense mutation (c.2120C > T, p.Pro707Leu) mapping to the RING domain. The identified missense mutation, as well as of another recently reported pathogenic missense mutation (c.2081G > A, p.Cys694Tyr), revealed that in vitro ubiquitylation activity was largely abrogated.

  5. findings suggest that the mutant LRSAM1 may aberrantly affect the formation of transcription machinery.

  6. findings demonstrate that the isolated genetic entity Charcot-Marie-Tooth type 2G is caused by a missense mutation in LRSAM1.

  7. LRSAM1 exhibited self-association in vitro and in vivo. The study found the self-association of LRSAM1 promotes intermolecular ubiquitination and proved a potential N-terminal ubiquitination.

  8. Plant homeodomain finger protein 23 negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1

  9. disruption of the C-terminal RING domain confers dominant negative properties to LRSAM1

  10. Our data further confirms that LRSAM1 mutations are associated with CMT2 of AD inheritance.

  11. Authors identify LRSAM1 as the E3 ligase responsible for anti-Salmonella autophagy-associated ubiquitination.

  12. homozygous mutation in LRSAM1 was proposed as a strong candidate for the disease in a family with recessive axonal polyneuropathy

  13. LRSAM1 as a component of the antibacterial autophagic response.

  14. LRSAM1 is a strong candidate for the causal gene for the Charcot-Marie-Tooth disease.

  15. Results suggest that RIFLE represents a novel signaling protein that mediates components of the Wnt/wingless signaling pathway and cell adhesion in PC12 cells [RIFLE protein].

  16. Tal regulates a Tsg101-associated complex responsible for the sorting of cargo into cytoplasm-containing vesicles that bud at the multivesicular body and at the plasma membrane

  17. Tal polyubiquitinates lysine residues in the C-terminus of uncomplexed Tsg101, resulting in proteasomal degradation.

Mouse (Murine) Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners

  1. downregulation of miR-431-5p promoted proliferation of enteric neural crest cells via targeting LRSAM1, which provides an innovative and candidate target for treatment of Hirschsprung's disease

  2. TLR4/NF-kappaB-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury.

  3. Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised.

LRSAM1 profil antigène

Profil protéine

This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with LRSAM1

  • leucine rich repeat and sterile alpha motif containing 1 (LRSAM1) anticorps
  • leucine rich repeat and sterile alpha motif containing 1 (Lrsam1) anticorps
  • CMT2P anticorps
  • RIFLE anticorps
  • TAL anticorps

Protein level used designations for LRSAM1

E3 ubiquitin-protein ligase LRSAM1 , Tsg101-associated ligase , leucine-rich repeat and sterile alpha motif-containing protein 1 , tsg101-associated ligase

GENE ID SPECIES
90678 Homo sapiens
227738 Mus musculus
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