Leucine Rich Repeat and Sterile alpha Motif Containing 1 Protéines (LRSAM1)

LRSAM1 encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. De plus, nous expédions LRSAM1 Anticorps (57) et LRSAM1 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
LRSAM1 90678 Q6UWE0
LRSAM1 227738 Q80ZI6
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Top LRSAM1 Protéines sur anticorps-enligne.fr

Showing 4 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails

LRSAM1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) partenaires d'interaction

Human Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners

  1. We identified a novel LRSAM1 missense mutation (c.2120C > T, p.Pro707Leu) mapping to the RING domain. The identified missense mutation, as well as of another recently reported pathogenic missense mutation (c.2081G > A, p.Cys694Tyr), revealed that in vitro ubiquitylation activity was largely abrogated.

  2. findings suggest that the mutant LRSAM1 may aberrantly affect the formation of transcription machinery.

  3. findings demonstrate that the isolated genetic entity Charcot-Marie-Tooth type 2G is caused by a missense mutation in LRSAM1.

  4. LRSAM1 exhibited self-association in vitro and in vivo. The study found the self-association of LRSAM1 promotes intermolecular ubiquitination and proved a potential N-terminal ubiquitination.

  5. Plant homeodomain finger protein 23 negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1

  6. disruption of the C-terminal RING domain confers dominant negative properties to LRSAM1

  7. Our data further confirms that LRSAM1 mutations are associated with CMT2 of AD inheritance.

  8. Authors identify LRSAM1 as the E3 ligase responsible for anti-Salmonella autophagy-associated ubiquitination.

  9. homozygous mutation in LRSAM1 was proposed as a strong candidate for the disease in a family with recessive axonal polyneuropathy

  10. LRSAM1 as a component of the antibacterial autophagic response.

Mouse (Murine) Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners

  1. TLR4 (Montrer TLR4 Protéines)/NF-kappaB (Montrer NFKB1 Protéines)-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury.

  2. Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised.

Profil protéine LRSAM1

Profil protéine

This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with LRSAM1

  • leucine rich repeat and sterile alpha motif containing 1 (LRSAM1)
  • leucine rich repeat and sterile alpha motif containing 1 (Lrsam1)
  • CMT2P Protéine
  • RIFLE Protéine
  • TAL Protéine

Protein level used designations for LRSAM1

E3 ubiquitin-protein ligase LRSAM1 , Tsg101-associated ligase , leucine-rich repeat and sterile alpha motif-containing protein 1 , tsg101-associated ligase

GENE ID SPECIES
90678 Homo sapiens
227738 Mus musculus
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