Ligand of Numb-Protein X 1 (LNX1) Kits ELISA

Zebrafish Ligand of Numb-Protein X 1 (LNX1) interaction partners

1. Bozozok (Boz, also known as Dharma or Nieuwkoid) as a binding partner and substrate of Lnx-l.

Mouse (Murine) Ligand of Numb-Protein X 1 (LNX1) interaction partners

1. Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1.

2. These findings provide functional insights into the LNX protein family, particularly the neuronal LNX1p70 isoform.

3. the PDZ domain-containing protein ligand-of-numb protein-X (LNX) is found in complex with the coxsackievirus and adenovirus receptor (CAR)

4. LNX1 may play a role in regulating neuregulin-1/ErbB signaling in perisynaptic Schwann cells.

5. LNX1 provides an endocytic scaffold for JAM4 that is implicated in the reorganization of cell junctions.

6. LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and the turnover of tight junctions is regulated by ubiquitylation.

Human Ligand of Numb-Protein X 1 (LNX1) interaction partners

1. Study reveals how the LNX1 RING domain is structurally and mechanistically dependent on other motifs for its E3 ligase activity, and describes how dimeric LNX1 recruits ubiquitin (Ub)-loaded Ubc13 for Ub transfer via E3 ligase-mediated catalysis.

2. study provided the evidences that LNX1 signaling plays important roles in regulating the stemness of colon cancer cells

3. LNX was closely related to human gliomas and suggested it plays an important role in gliomas by notch signaling.

4. LNX1-mediated ubiquitination and degradation of PBK inhibited cell proliferation and enhanced sensitivity to doxorubicin-induced apoptosis.

5. identify and confirm six novel LNX1 binding partners: KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2 and PBK, and suggest that LNX1 functions as a signalling scaffold.

6. The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever.

7. LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis

8. Down-regulation of LNX could result in cell cycle arrest in G0/G1 phase through inhibition of beta-catenin, MAPK, NFkappaB, c-Myc-dependent pathway and activation of p53, TGF-beta-dependent pathway.

9. LNX and RhoC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1.

10. identifed ligand of Numb protein X as an Np9-interacting partner; findings point to the possibility that Np9 affects tumorigenesis through the LNX/Numb/Notch pathway

11. The presence of multiple protein binding domains involved in signal transduction and interaction with Numb and SKIP suggested an important role for LNX in tumorogenesis.

12. The interaction of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src.

13. Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas.

14. A direct interaction between ErbB2 and mouse LNX1 was identified, suggesting that LNX1 may be involved in neuregulin-1/ErbB signaling in perisynaptic Schwann cells.

15. The tyrosine phosphorylation of the LDNPAY sequence motif in mouse LNX could generate a binding site for the phosphorylation-dependent binding of other PTB domain-containing proteins.

16. Describes various glioblastoma multiforms containing the amplicon on chromosomal segment 4q12, including the LNX1 gene.