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Mouse studies suggest that LPIN2 functions during normal adipose tissue development and may play a role in human triglyceride metabolism. De plus, nous expédions Lipin 2 Protéines (3) et et beaucoup plus de produits pour cette protéine.
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Human Polyclonal LPIN2 Primary Antibody pour ELISA - ABIN547407
Phan, Péterfy, Reue: Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. dans The Journal of biological chemistry 2004
lipin-2 control TLR4 signaling, and P2X7R activation and sensitization, that finally culminate in a restricted activation of NLRP3 inflammasome.
we proposed that four newly identified peripheral blood mononuclear cells-derived genes( DHRS3, TTC38, SAP30BP and LPIN2 )could be integrated with previously reported rheumatoid arthritis (RA)-associated genes to monitor and/or diagnose RA.
Structural variants unique to the malignant cell line inactivated: LPIN2, a phosphatidic acid phosphatase and a co-factor of PGC1a that is important for lipid metabolism and for suppressing autoinflammation.
We describe two brothers with Majeed syndrome, homozygous novel 2-base pair deletion in LPIN2 (c.1312_1313delCT; p.Leu438fs+16X)
LPIN1-related myolysis constitutes a major cause of early-onset rhabdomyolysis and occasionally in adults. Heterozygous LPIN1 mutations may cause mild muscular symptoms. No major defects of LPIN2 or LPIN3 genes were associated with muscle manifestations.
role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages
Data revealed that lipin 1 formed stable homo-oligomers with itself and hetero-oligomers with lipin 2/3.
LPIN2 gene was excluded as a candidate for myopia 2 (MYP2), but the SNPs detected in this study will aid in future mapping and association studies involving this gene.
We conclude that homozygous mutations in LPIN2 result in Majeed syndrome. Understanding the aberrant immune response in this condition will shed light on the aetiology of other inflammatory disorders of multifactorial aetiology
A single nucleotide polymorphism of the LPIN2 gene is associated with type 2 diabetes and fat distribution.
distinct and non-redundant functions of lipin 1 and 2 regulate lipid production during the cell cycle and adipocyte differentiation
lipin 2 plays an important role as a hepatic PAP-1 enzyme.
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Association analysis showed that different genotypes of LPIN2 were associated with back-fat thickness between the 6th and 7th ribs (P < 0.01).
Suppression of lipin 1 and lipin2 are the primary mechanism of increased phosphatidic acid levels in the liver during acetaminophen-induced liver injury and recovery.
Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond but the phosphorylation of lipin 2 is not induced by insulin signaling.
in addition to their roles during early adipogenesis, lipin1 and lipin2 also have a role in lipid droplet biogenesis.
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
Data show that in the high-Chol diet apoE-KO mice, the mRNA and protein expression of lipin-1 and lipin-2 was markedly decreased.
The results demonstrate that ER stress-induced LIPIN2 would contribute to the perturbation of hepatic insulin signaling via a DAG-protein kinase C epsilon-dependent manner in DIO mice.
Lipin-2 exhibits phosphatidate phosphatase type-1 (PAP1) activity, which has a key role in glycerolipid synthesis.
Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
, phosphatidate phosphatase LPIN2
, phosphatidate phosphatase LPIN2-like