anti-Lon Peptidase 1, Mitochondrial (LONP1) Anticorps

LONP1 encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases.

afficher tous les anticorps Gène GeneID UniProt
Anti-Humain LONP1 LONP1 9361 P36776
Anti-Souris LONP1 LONP1 74142 Q8CGK3
Anti-Rat LONP1 LONP1 170916 Q924S5
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top anti-Lon Peptidase 1, Mitochondrial Anticorps sur anticorps-enligne.fr

Showing 10 out of 84 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), SimWes, WB Western Blot: LONP1 Antibody [NBP1-81734] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells). Lane 3: PC12 cell lysate (Pheochromocytoma of rat adrenal medulla). Immunofluorescence: LONP1 Antibody [NBP1-81734] - Staining of human cell line U-251 MG shows positivity in mitochondria. Antibody staining is shown in green. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human cervical carcinoma labeled with Anti- LONP1 Polyclonal Antibody, Unconjugated (ABIN705806) at 1:200 followed by conjugation to the secondary antibody Formalin-fixed and paraffin embedded rat colon labeled with Anti- LONP1 Polyclonal Antibody, Unconjugated (ABIN705806) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C 100 μL Connectez-vous pour afficher 3 to 7 Days
$306.90
Détails
Humain Lapin Inconjugué WB LONP1 Antibody (Center) (ABIN1881504) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the LONP1 antibody detected the LONP1 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué IF, WB LONP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in human kidney. LONP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in mouse kidney. 100 μg Connectez-vous pour afficher 11 to 12 Days
$425.71
Détails
Humain Lapin Inconjugué WB Western blot analysis in Hela cell line lysates (35ug/lane). 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extract of various cells, using LONP1 antibody. 100 μL Connectez-vous pour afficher 16 Days
$476.15
Détails
Humain Souris Inconjugué ELISA, IHC, WB Western Blot: LONP1 Antibody (LON20/H1) [NBP2-50478] - U87 cells were transfected with siRNA against the Lon protease (siLonp1.1 and siLonp1.2) or a control sequence (siControl) or transfection reagent alone (mock) and then western blotted using anti-LONP1 [LON20/H1] and a loading control antibody (B-actin). Molecular weight markers are labelled in kilodaltons 0.1 mL Connectez-vous pour afficher 34 Days
$345.00
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 200 μL Connectez-vous pour afficher 7 to 9 Days
$484.00
Détails
Humain Lapin Alexa Fluor 488 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails
Humain Lapin Alexa Fluor 647 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails

anti-Lon Peptidase 1, Mitochondrial Anticorps mieux référencés

  1. Human Polyclonal LONP1 Primary Antibody pour WB - ABIN1881504 : Merra, Lago, Ricci, Antuzzi, Gasbarrini, Gasbarrini, Ghirlanda: Splenomegaly as a primary manifestation of Gaucher disease in a young adult woman. dans Case reports in gastroenterology 2011 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal LONP1 Primary Antibody pour ICC, IF - ABIN4331301 : Gozal, Duong, Gearing, Cheng, Hanfelt, Funderburk, Peng, Lah, Levey: Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer's disease. dans Journal of proteome research 2009 (PubMed)
    Show all 4 Pubmed References

Plus d’anticorps contre Lon Peptidase 1, Mitochondrial partenaires d’interaction

Human Lon Peptidase 1, Mitochondrial (LONP1) interaction partners

  1. mitochondrial ATP-dependent Lon protease may serve as a potential biomarker for cancer diagnosis and novel target for the development of anticancer drugs and for predicting of the efficiency and effectiveness of chemotherapy of a variety of cancers.

  2. We demonstrate that Lon plays a key role in glioma cell hypoxic survival and mitochondrial respiration, and propose Lon as a promising therapeutic target in the treatment of malignant gliomas.

  3. Some features were not consistent with CODAS syndrome but overlapped with Marinesco-Sjogren syndrome, a multisystem disorder caused by a mutation in SIL1 (Montrer SIL1 Anticorps). An atypical mutation site may result in atypical presentation of the LONP1 mutation

  4. LONP1 function and implication in human aging and disease was reviewed.

  5. we observed that Lon protease downregulation is linked to a higher lipofuscinogenesis whereas the application of the mitochondrial-targeted antioxidant mitoTEMPO is able to prevent the accumulation of this protein aggregate.

  6. Lon preferentially degrades the phosphorylated subunits of CcO (Montrer RYR1 Anticorps) and plays a role in the regulation of CcO (Montrer RYR1 Anticorps) activity in hypoxia and ischemia/reperfusion injury.

  7. Lon protease (Lonp1), which is a key inductive of mitochondrial unfolded protein response (UPR(mt)) and is required to maintain the mitochondrial quality, was greatly induced in H. pylori infected gastric epithelial cells.

  8. Mutations of Lon, which likely impair its chaperone properties, are at the basis of a genetic inherited disease named the cerebral, ocular, dental, auricular, skeletal (CODAS) syndrome. (Review)

  9. Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells.

  10. Lon downregulation attenuated hypoxia-induced cardiomyocyte apoptosis through a reduction of reactive oxygen species level.

Mouse (Murine) Lon Peptidase 1, Mitochondrial (LONP1) interaction partners

  1. these findings suggest that Lon protease may be particularly vulnerable to inactivation in conditions associated with elevated oxidative stress resulting in mitochondrial dysfunction and neuron cell death, an early event in the pathogenesis of Parkinson's disease

  2. Lon preferentially degrades the phosphorylated subunits of CcO (Montrer RYR1 Anticorps) and plays a role in the regulation of CcO (Montrer RYR1 Anticorps) activity in hypoxia and ischemia/reperfusion injury.

  3. Lon protease (Lonp1), which is a key inductive of mitochondrial unfolded protein response (UPR(mt)) and is required to maintain the mitochondrial quality, was greatly induced in H. pylori infected gastric epithelial cells.

  4. LONP1 knockdown inhibits cellular proliferation and tumor and metastasis formation, whereas its overexpression increases tumorigenesis.

  5. Epidermal growth factor (Montrer EGF Anticorps) up-regulates the transcription of ATP-dependent protease through extracellular signal-regulated protein kinase (Montrer CDK7 Anticorps)- and 1-phosphatidylinositol 3-kinase (Montrer PIK3CG Anticorps)-dependent pathways.

  6. Modulation of Lon protease activity during aging and oxidative stress.

  7. The correlative effect of Lon and ClpP (Montrer CLPP Anticorps) upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP (Montrer CLPP Anticorps) proteases in FRDA (Montrer FXN Anticorps).

Lon Peptidase 1, Mitochondrial (LONP1) profil antigène

Profil protéine

This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with LONP1

  • lon peptidase 1, mitochondrial (LONP1) anticorps
  • lon peptidase 1, mitochondrial (lonp1) anticorps
  • lon peptidase 1, mitochondrial (Lonp1) anticorps
  • ATP-dependent Lon protease (PIM1) anticorps
  • 1200017E13Rik anticorps
  • fc64d11 anticorps
  • hLON anticorps
  • Lon anticorps
  • LonHS anticorps
  • LONP anticorps
  • PIM1 anticorps
  • Prss15 anticorps
  • wu:fc64d11 anticorps

Protein level used designations for LONP1

lon peptidase 1, mitochondrial , protease, serine, 15 , lon protease homolog, mitochondrial-like , hLON ATP-dependent protease , lon protease homolog, mitochondrial , mitochondrial ATP-dependent protease Lon , mitochondrial lon protease-like protein , serine protease 15 , LONP , lon protease-like protein , ATP-dependent Lon protease , hypothetical protein

GENE ID SPECIES
455623 Pan troglodytes
563257 Danio rerio
100024990 Monodelphis domestica
100074993 Ornithorhynchus anatinus
100408135 Callithrix jacchus
100468447 Ailuropoda melanoleuca
100538450 Meleagris gallopavo
100590941 Nomascus leucogenys
9361 Homo sapiens
74142 Mus musculus
170916 Rattus norvegicus
768942 Gallus gallus
611425 Canis lupus familiaris
100511917 Sus scrofa
510796 Bos taurus
3640999 Candida albicans SC5314
Avez-vous cherché autre chose?