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Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. De plus, nous expédions LRP10 Protéines (11) et beaucoup plus de produits pour cette protéine.
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Our findings implicate LRP10 gene defects in the development of inherited forms of alpha-synucleinopathies
In Mayer-Rokitansky-Kuster-Hauser syndrome in monoztgotic twins, LRP10 was identified as one of the candidate genes.
Increased expression of LRP10 in human neuroblastoma SH-SY5Y cells induces the accumulation of mature APP in the Golgi and reduces its presence at the cell surface and its processing into Abeta.
LRP10 may interfere with the formation of the beta-catenin/TCF complex and/or its binding to target DNA in the nucleus, and that the extracellular domain of LRP10 is critical for inhibition of the canonical Wnt/beta-catenin signaling pathway.
These results suggest that LRP9 cycles between the trans-Golgi network, endosomes and the plasma membrane through a GGA dependent-trafficking mechanism.
Data show that Calnuc is involved in LRP9 endosomal sorting to prevent the delivery of LRP9 to lysosomes.
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver.
, low-density lipoprotein receptor-related protein 10