Lysine (K)-Specific Demethylase 1B Protéines (KDM1B)

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009].. De plus, nous expédions KDM1B Anticorps (40) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
KDM1B 221656 Q8NB78
KDM1B 218214 Q8CIG3
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Baculovirus Humain GST tag KDM1B / LSD2 activity assay. Recombinant KDM1B / LSD2 activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant KDM1B / LSD2 protein gel. Recombinant KDM1B / LSD2 run on an SDS-PAGE gel and stained with Coomassie blue. 20 μg Connectez-vous pour afficher 1 to 2 Days
$478.33
Détails

KDM1B Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Lysine (K)-Specific Demethylase 1B (KDM1B) partenaires d'interaction

Human Lysine (K)-Specific Demethylase 1B (KDM1B) interaction partners

  1. These results suggest that LSD2 achieves a promoting effect on small cell lung cancer by indirectly regulating TFPI2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPI2 gene.

  2. This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes.

  3. These results demonstrate an important role for LSD2 in regulation of DNA methylation and gene silencing in breast cancer.

  4. Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT.

  5. Using transcriptome and chromatin immunoprecipitation-sequencing analyses, the study revealed that LSD2 represses the genes involved in lipid influx and metabolism through demethylation of histone H3K4.

  6. regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2

  7. The zinc finger-SWIRM-oxidase domains is required for KDM1B demethylase activity and the binding of FAD.

  8. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

Mouse (Murine) Lysine (K)-Specific Demethylase 1B (KDM1B) interaction partners

  1. reveal a direct role of hypoxia-inducible factor in regulating miRNA biogenesis and consequently activating the miR-215-KDM1B-mediated signaling required for glioma-initiating cells adaptation to hypoxia

  2. Data indicate that Myst4, Jmjd2b, Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia.

  3. AOF1 is the second histone demethylase in the family of flavin-dependent amine oxidases and reveals a demethylase-independent repression function.

  4. oocytes from KDM1B-deficient females showed a substantial increase in H3K4 methylation and failed to set up the DNA methylation marks at four out of seven imprinted genes examined

Profil protéine KDM1B

Profil protéine

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009

Gene names and symbols associated with KDM1B

  • lysine demethylase 1B (KDM1B)
  • lysine-specific histone demethylase 1B (LOC577549)
  • lysine (K)-specific demethylase 1B (kdm1b)
  • lysine demethylase 1B (kdm1b)
  • lysine (K)-specific demethylase 1B (Kdm1b)
  • 4632428N09Rik Protéine
  • AI482520 Protéine
  • Aof1 Protéine
  • bA204B7.3 Protéine
  • C6orf193 Protéine
  • dJ298J15.2 Protéine
  • LSD2 Protéine

Protein level used designations for KDM1B

amine oxidase (flavin containing) domain 1 , lysine (K)-specific demethylase 1B , lysine-specific histone demethylase 1B-like , amine oxidase, flavin containing 1 , flavin-containing amine oxidase domain-containing protein 1 , lysine-specific histone demethylase 1B , lysine-specific histone demethylase 2

GENE ID SPECIES
513667 Bos taurus
577549 Strongylocentrotus purpuratus
100066240 Equus caballus
100401095 Callithrix jacchus
100443986 Pongo abelii
100481180 Ailuropoda melanoleuca
100489838 Xenopus (Silurana) tropicalis
100547778 Meleagris gallopavo
100552653 Anolis carolinensis
221656 Homo sapiens
218214 Mus musculus
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