Lysine (K)-Specific Demethylase 2A Protéines (KDM2A)

KDM2A encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions KDM2A Anticorps (84) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
KDM2A 225876 P59997
Rat KDM2A KDM2A 361700  
KDM2A 22992 Q9Y2K7
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
Baculovirus infected Insect Cells Humain GST tag   20 μg Connectez-vous pour afficher 1 to 2 Days

KDM2A Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , , ,

Plus protéines pour Lysine (K)-Specific Demethylase 2A (KDM2A) partenaires d'interaction

Pig (Porcine) Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. JHDM1A is differentially expressed in porcine embryonic skeletal muscle and associated with meat growth and quality traits.

Mouse (Murine) Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. Kdm2a expression may be closely related to cell proliferation

  2. Fbxl11 plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival.

  3. we identify Jhdm1a negatively regulates gluconeogenic gene PEPCK and G6Pase expression both in vitro and in vivo

  4. Data describe a NF-kappaB regulatory pathway that is driven by reversible lysine methylation of p65, carried out by nuclear receptor-binding SET domain-containing protein 1 (NSD1) and F-box and leucine-rich repeat protein 11 (FBXL11).

Human Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. KDM2B is crucial for glioblastoma maintenance, with it's inhibition causing loss of glioblastoma stem-like cells survival, genomic stability, and chemoresistance.

  2. Study data revealed that KDM2A functions as a tumor oncogene, and the downregulation of KDM2A expression regulates Epithelialmesenchymal transition and epithelial ovarian cancer progression.

  3. KDM2A-SF forms distinct nuclear heterochromatic bodies in an HP1a dependent manner

  4. Authors conclude that KDM2A functions as an oncogene in breast cancer by upregulating JAG1 to promote stemness, chemoresistance and angiogenesis.

  5. Identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protein 1 (HP1) interaction motif that mediates direct binding between KDM2A and HP1. This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.

  6. The miR-29b/KDM2A axis was involved in the RUNX3-mediated inhibition of gastric cancer cell proliferation and metastasis.

  7. KDM2A-WWTR1 fusion is associated with ossifying fibromyxoid tumors.

  8. Silencing KDM2A, a histone demethylase and BCL6 co-repressor, de-repressed SFRP2 transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 promoter.

  9. Findings suggest that amplification and overexpression of the KDM2A short isoform is critical in breast cancer progression.

  10. In this study, KDM2A was identified as a novel substrate of ATM. DSB enhanced the interaction between ATM and KDM2A, which induced ATM-mediated phosphorylation of KDM2A at T632.

  11. The results suggest that under mild glucose starvation AMP-activated kinase induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation.

  12. FBXL11 is proposed as a novel component of the circadian clock that regulates the circadian gene expression by a so far unknown mechanism.

  13. The protein lysine demethylases Kdm2a and Kdm2b regulate the turnover of non-phosphorylated beta-catenin specifically within the nucleus via direct interaction with the fourth and fifth armadillo repeats.

  14. Upregulation of KDM2A is very important in the progression of gastric cancer.

  15. a regulatory role for KDM2A in breast cancer cell invasion and migration, through the regulation of E2F1 function

  16. KDM2A binds to the rDNA promoter with unmethylated CpG sequences via the CxxC-ZF domain

  17. KDM2A represses histone deacetylase 3 and has a role in tumorigenicity of lung cancer cells

  18. KDMA2 is frequently overexpressed in NSCLC tumors & cell lines. It is needed for in vitro proliferation & invasion. KDM2A activated ERK1/2 by epigenetic repression of DUSP3 expression via demethylation of dimethylated H3K36 at the DUSP3 locus.

  19. KDM2A is a H3K4 demethylase that regulates cell proliferation through p15(INK4B) and p27(Kip1) in stem cells from apical papilla.

  20. FBXL11 inhibited osteo/dentinogenic differentiation potential in MSC cells by associating with BCOR, then increasing histone K4/36 methylation in Epiregulin promoter to repress Epiregulin transcription.

Zebrafish Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. loss of the orthologue kdm2aa in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanomas at a high frequency

Profil protéine KDM2A

Profil protéine

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KDM2A

  • lysine demethylase 2A (KDM2A)
  • lysine (K)-specific demethylase 2A (Kdm2a)
  • lysine demethylase 2A (Kdm2a)
  • lysine (K)-specific demethylase 2Aa (kdm2aa)
  • 5530401A10Rik Protéine
  • 100043628 Protéine
  • AA589516 Protéine
  • AW536790 Protéine
  • CXXC8 Protéine
  • fb76b11 Protéine
  • FBL7 Protéine
  • FBL11 Protéine
  • Fbxl11 Protéine
  • Gm4560 Protéine
  • Jhdm1 Protéine
  • Jhdm1a Protéine
  • KDM2A Protéine
  • lalina Protéine
  • LILINA Protéine
  • wu:fb76b11 Protéine
  • wu:fj11c04 Protéine
  • zgc:158441 Protéine
  • zgc:158606 Protéine

Protein level used designations for KDM2A

F-box and leucine-rich repeat protein 11 , jumonji C domain-containing histone demethylase 1A , lysine-specific demethylase 2A , F-box protein containing leucine repeats , F-box/LRR-repeat protein 11 , [Histone-H3]-lysine-36 demethylase 1A , jmjC domain-containing histone demethylation protein 1A , lysine (K)-specific demethylase 2A , CXXC-type zinc finger protein 8 , JmjC domain-containing histone demethylation protein 1B , lysine (K)-specific demethylase 2B

100294703 Sus scrofa
540141 Bos taurus
225876 Mus musculus
483702 Canis lupus familiaris
361700 Rattus norvegicus
22992 Homo sapiens
571851 Danio rerio
100052955 Equus caballus
100732285 Cavia porcellus
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