Lysine (K)-Specific Demethylase 2A Protéines (KDM2A)

KDM2A encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions KDM2A Anticorps (81) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
KDM2A 225876 P59997
Rat KDM2A KDM2A 361700  
KDM2A 22992 Q9Y2K7
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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KDM2A Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,
,

Plus protéines pour Lysine (K)-Specific Demethylase 2A (KDM2A) partenaires d'interaction

Pig (Porcine) Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. JHDM1A is differentially expressed in porcine embryonic skeletal muscle and associated with meat growth and quality traits.

Mouse (Murine) Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. Kdm2a (Montrer KDM3A Protéines) expression may be closely related to cell proliferation

  2. Fbxl11 plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival.

  3. we identify Jhdm1a negatively regulates gluconeogenic gene PEPCK (Montrer PEPCK Protéines) and G6Pase (Montrer G6PC Protéines) expression both in vitro and in vivo

  4. Data describe a NF-kappaB (Montrer NFKB1 Protéines) regulatory pathway that is driven by reversible lysine methylation of p65 (Montrer NFkBP65 Protéines), carried out by nuclear receptor-binding SET domain-containing protein 1 (NSD1) and F-box and leucine-rich repeat protein 11 (FBXL11).

Human Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. KDM2A-SF forms distinct nuclear heterochromatic bodies in an HP1a (Montrer TFF1 Protéines) dependent manner

  2. Authors conclude that KDM2A functions as an oncogene (Montrer RAB1A Protéines) in breast cancer by upregulating JAG1 (Montrer JAG1 Protéines) to promote stemness, chemoresistance and angiogenesis.

  3. Identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD (Montrer PDC Protéines) domain and a newly identified Heterochromatin Protein 1 (HP1 (Montrer DEFA1 Protéines)) interaction motif that mediates direct binding between KDM2A and HP1 (Montrer DEFA1 Protéines). This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.

  4. The miR (Montrer MLXIP Protéines)-29b/KDM2A axis was involved in the RUNX3 (Montrer RUNX3 Protéines)-mediated inhibition of gastric cancer cell proliferation and metastasis.

  5. KDM2A-WWTR1 (Montrer WWTR1 Protéines) fusion is associated with ossifying fibromyxoid tumors.

  6. Silencing KDM2A, a histone demethylase (Montrer MBD2 Protéines) and BCL6 co-repressor (Montrer BCOR Protéines), de-repressed SFRP2 (Montrer SFRP2 Protéines) transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 (Montrer SFRP2 Protéines) promoter.

  7. Findings suggest that amplification and overexpression of the KDM2A short isoform is critical in breast cancer progression.

  8. In this study, KDM2A was identified as a novel substrate of ATM (Montrer ATM Protéines). DSB enhanced the interaction between ATM (Montrer ATM Protéines) and KDM2A, which induced ATM (Montrer ATM Protéines)-mediated phosphorylation of KDM2A at T632.

  9. The results suggest that under mild glucose starvation AMP (Montrer APRT Protéines)-activated kinase induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation.

  10. FBXL11 is proposed as a novel component of the circadian clock that regulates the circadian gene expression by a so far unknown mechanism.

Zebrafish Lysine (K)-Specific Demethylase 2A (KDM2A) interaction partners

  1. loss of the orthologue kdm2aa (Montrer KDM2B Protéines) in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanomas at a high frequency

Profil protéine KDM2A

Profil protéine

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KDM2A

  • lysine demethylase 2A (KDM2A)
  • lysine (K)-specific demethylase 2A (Kdm2a)
  • lysine demethylase 2A (Kdm2a)
  • lysine (K)-specific demethylase 2Aa (kdm2aa)
  • 5530401A10Rik Protéine
  • 100043628 Protéine
  • AA589516 Protéine
  • AW536790 Protéine
  • CXXC8 Protéine
  • fb76b11 Protéine
  • FBL7 Protéine
  • FBL11 Protéine
  • Fbxl11 Protéine
  • Gm4560 Protéine
  • Jhdm1 Protéine
  • Jhdm1a Protéine
  • KDM2A Protéine
  • lalina Protéine
  • LILINA Protéine
  • wu:fb76b11 Protéine
  • wu:fj11c04 Protéine
  • zgc:158441 Protéine
  • zgc:158606 Protéine

Protein level used designations for KDM2A

F-box and leucine-rich repeat protein 11 , jumonji C domain-containing histone demethylase 1A , lysine-specific demethylase 2A , F-box protein containing leucine repeats , F-box/LRR-repeat protein 11 , [Histone-H3]-lysine-36 demethylase 1A , jmjC domain-containing histone demethylation protein 1A , lysine (K)-specific demethylase 2A , CXXC-type zinc finger protein 8 , JmjC domain-containing histone demethylation protein 1B , lysine (K)-specific demethylase 2B

GENE ID SPECIES
100294703 Sus scrofa
540141 Bos taurus
225876 Mus musculus
483702 Canis lupus familiaris
361700 Rattus norvegicus
22992 Homo sapiens
571851 Danio rerio
100052955 Equus caballus
100732285 Cavia porcellus
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