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KDM2A encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions KDM2A Anticorps (81) et et beaucoup plus de produits pour cette protéine.
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JHDM1A is differentially expressed in porcine embryonic skeletal muscle and associated with meat growth and quality traits.
Kdm2a (Montrer KDM3A Protéines) expression may be closely related to cell proliferation
Fbxl11 plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival.
we identify Jhdm1a negatively regulates gluconeogenic gene PEPCK (Montrer PEPCK Protéines) and G6Pase (Montrer G6PC Protéines) expression both in vitro and in vivo
Data describe a NF-kappaB (Montrer NFKB1 Protéines) regulatory pathway that is driven by reversible lysine methylation of p65 (Montrer NFkBP65 Protéines), carried out by nuclear receptor-binding SET domain-containing protein 1 (NSD1) and F-box and leucine-rich repeat protein 11 (FBXL11).
KDM2A-SF forms distinct nuclear heterochromatic bodies in an HP1a (Montrer TFF1 Protéines) dependent manner
Authors conclude that KDM2A functions as an oncogene (Montrer RAB1A Protéines) in breast cancer by upregulating JAG1 (Montrer JAG1 Protéines) to promote stemness, chemoresistance and angiogenesis.
Identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD (Montrer PDC Protéines) domain and a newly identified Heterochromatin Protein 1 (HP1 (Montrer DEFA1 Protéines)) interaction motif that mediates direct binding between KDM2A and HP1 (Montrer DEFA1 Protéines). This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.
The miR (Montrer MLXIP Protéines)-29b/KDM2A axis was involved in the RUNX3 (Montrer RUNX3 Protéines)-mediated inhibition of gastric cancer cell proliferation and metastasis.
KDM2A-WWTR1 (Montrer WWTR1 Protéines) fusion is associated with ossifying fibromyxoid tumors.
Silencing KDM2A, a histone demethylase (Montrer MBD2 Protéines) and BCL6 co-repressor (Montrer BCOR Protéines), de-repressed SFRP2 (Montrer SFRP2 Protéines) transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 (Montrer SFRP2 Protéines) promoter.
Findings suggest that amplification and overexpression of the KDM2A short isoform is critical in breast cancer progression.
In this study, KDM2A was identified as a novel substrate of ATM (Montrer ATM Protéines). DSB enhanced the interaction between ATM (Montrer ATM Protéines) and KDM2A, which induced ATM (Montrer ATM Protéines)-mediated phosphorylation of KDM2A at T632.
The results suggest that under mild glucose starvation AMP (Montrer APRT Protéines)-activated kinase induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation.
FBXL11 is proposed as a novel component of the circadian clock that regulates the circadian gene expression by a so far unknown mechanism.
loss of the orthologue kdm2aa (Montrer KDM2B Protéines) in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanomas at a high frequency
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
F-box and leucine-rich repeat protein 11
, jumonji C domain-containing histone demethylase 1A
, lysine-specific demethylase 2A
, F-box protein containing leucine repeats
, F-box/LRR-repeat protein 11
, [Histone-H3]-lysine-36 demethylase 1A
, jmjC domain-containing histone demethylation protein 1A
, lysine (K)-specific demethylase 2A
, CXXC-type zinc finger protein 8
, JmjC domain-containing histone demethylation protein 1B
, lysine (K)-specific demethylase 2B