anti-Lysyl Oxidase-Like 1 (LOXL1) Anticorps

LOXL1 encodes a member of the lysyl oxidase gene family. De plus, nous expédions LOXL1 Protéines (17) et LOXL1 Kits (14) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
LOXL1 4016 Q08397
LOXL1 16949 P97873
LOXL1 315714  
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Showing 10 out of 89 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-LOXL1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysate 100 μL 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-LOXL1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human Lung 100 μL 2 to 3 Days
Humain Lapin Inconjugué IHC (p), WB Observed bind size: 63KD Anti- LOXL1 Picoband antibody, IHC(P) IHC(P): Human Prostatic Cancer Tissue 100 μg 4 to 6 Days
Boeuf (Vache) Lapin Inconjugué WB 100 μL 11 to 14 Days
Boeuf (Vache) Lapin Inconjugué WB 100 μL 11 to 14 Days
Humain Lapin Inconjugué ELISA, WB 100 μL 11 to 14 Days
Humain Lapin Inconjugué WB 100 μL 11 to 14 Days
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cells, using LOXL1 antibody. Western blot analysis of extracts of various cell lines, using LOXL1 antibody (ABIN4904244) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s. 100 μL 11 to 13 Days
Humain Lapin Inconjugué ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
Humain Lapin Inconjugué ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 15 to 18 Days

anti-LOXL1 Anticorps mieux référencés

  1. Human Polyclonal LOXL1 Primary Antibody pour IF, WB - ABIN517560 : Sethi, Mao, Wordinger, Clark: Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. dans Investigative ophthalmology & visual science 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal LOXL1 Primary Antibody pour WB - ABIN517559 : Schlötzer-Schrehardt, Hammer, Krysta, Hofmann-Rummelt, Pasutto, Sasaki, Kruse, Zenkel: LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma. dans Ophthalmology 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal LOXL1 Primary Antibody pour DB, ELISA - ABIN549499 : Trackman, Bedell-Hogan, Tang, Kagan: Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor. dans The Journal of biological chemistry 1992 (PubMed)
    Show all 3 Pubmed References

  4. Cow (Bovine) Polyclonal LOXL1 Primary Antibody pour WB - ABIN2785878 : Ohmura, Yasukawa, Minami, Sugi, Oba, Nagata, Kyogoku, Ohshima, Aoki, Imaizumi: Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice. dans Hypertension research : official journal of the Japanese Society of Hypertension 2012 (PubMed)

Plus d’anticorps contre LOXL1 partenaires d’interaction

Rhesus Monkey Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. high lysyl oxidase activity is associated with ischemic hearts.

Human Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. The study shows lack of association between LOXL1 single-nucleotide polymorphisms and pseudoexfoliation in North Indian population.

  2. Findings indicate that lysyl oxidase (LOX) could be a potential therapeutic target for early recurrence of hepatocellular carcinoma (HCC).

  3. LOXL1 variants that contribute to exfoliative glaucoma demonstrate various differences and are also common in normal population.

  4. LOXL1, LOXL3, and LOXL4 expressions are associated with distant metastasis of gastric cancer.

  5. The current study aimed to investigate the role of LOXL1 in liver fibrosis and the potential mechanism; the mRNA and protein levels of LOXL1 were increased in transforming growth factor-beta 1 (TGF-beta1)-stimulated human hepatic stellate cell line LX-2.

  6. the rs11638944:C>G transversion exerts a cis-acting effect on the expression levels of LOXL1, mediated by differential binding of the transcription factor retinoid X receptor alpha and by modulating alternative splicing of LOXL1, eventually leading to reduced levels of LOXL1 mRNA in cells and tissues of risk allele carriers for pseudoexfoliation syndrome

  7. LOXL1/LOXL2 gene expression and protein levels were increased in Idiopathic pulmonary fibrosis (IPF) versus non-IPF.

  8. This study focused on the relationship between lysyl oxidase (LOX), LOX-like protein 1 (LOXL1), and LOXL2 and pulmonary emphysema pathogenesis.

  9. These findings provide evidence for a functional role of alternative splicing coupled to NMD in the posttranscriptional regulation of LOXL1 gene expression and suggest this mechanism to represent a dynamic mode of adapting LOXL1 expression to PEX-associated environmental and nutritional cues.

  10. remenopausal and postmenopausal women with Pelvic Organ Prolapse (POP) exhibit differential expression of LOXL1 suggesting different pathways in the pathogenesis of POP. The role of biopsy location on LOXL1 expression requires further investigation.

  11. In this study, we found no significant association between allele and genotype frequencies of APOE; the intronic SNP rs2165241 and the non-synonymous SNP rs3825942 in exon 1 of LOXL1 are significantly associated with pseudoexfoliation syndrome and exfoliation glaucoma in the Turkish population.

  12. The LOXL1 SNPs, rs1048661 and rs3825942, are associated with PXF in the South Indian population correlating with lowered LOX activity in the aqueous humor. The increased level of total TGF-beta in the aqueous humor of PXF cases is possibly associated with LOX regulation which needs further investigation.

  13. A rare protective allele at LOXL1,Tyr407Phe, was identified. It is found exclusively in the Japanese population. It confers 25-fold resistance to XFS. It segregated with the common rs3825942[A] (p.Asp153) in all but 2 patients examined. In spheroids, this haplotype conferred a significant increase in the strength of cellular adhesion in comparison to 3 haplotypes with the wild-type allele.

  14. Findings of this current study indicate a different LOXL1 gene expression pattern compared with a recent study that was also performed in the Turkish population.

  15. LOXL1 transcriptional activity was dramatically reduced when a recombinant DNMT3A was concomitantly overexpressed.

  16. The present study, for the first time, shows that the pseudoexfoliation syndrome-associated variant residues in LOXL1 influence processing of the protein, most likely by BMP-1.

  17. In this study group of Turkish population, no LOXL1 mutations were found. No associations between the defined SNPs (A320A, R141L and F184F) and the severity of the disease were detected.

  18. Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue

  19. To identify additional candidate functional variants, we sequenced the entire LOXL1 genomic locus ( approximately 40 kb) in 50 indigenous, black South African XFS cases and 50 matched controls.

  20. This is the first study associating two SNPs of LOXL1 (rs3825942 and rs2165241) and XFS/XFG in a Spanish population, confirming findings in patients from Europe.

Cow (Bovine) Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. The enzyme has a very stable central core containing three disulfide bonds, the lysyl tyrosyl quinone cross-link and the copper.

Mouse (Murine) Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. LOXL1-deficient mice are protected from experimental lung fibrosis induced by overexpression of TGF-beta1 using adenoviral (Ad) gene transfer (AdTGF-beta1) by preventing accumulation of insoluble cross-linked collagen in the lungs, and therefore limiting lung stiffness.

  2. the copper transporter ATP7A is necessary for the activity of LOX and LOXL enzymes. Silencing of ATP7A inhibited LOX activity in the 4T1 mammary carcinoma cell line.

  3. We conclude that LOXL1 has a strong tendency to aggregate in the rER when expressed in vivo at high amounts. A similar scenario, involving intracellular aggregation of LOXL1 and secretion of LOXL1 aggregates into the extracellular space, may be involved in the early pathogenetic events in eyes of PEX patients.

  4. findings strongly suggested that elastin crosslinking and LOXL1 were co-associated with liver cirrhosis, while selective inhibition of LOXL1 arrested disease progression by reducing crosslinking of elastin.

  5. LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females

  6. Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma.

  7. There is a possible fundamental role of LOXL-1 in cardiac hypertrophy.

  8. loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype

  9. Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted long-term potentiation compared to LOXL +/+ mice.

  10. pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers

  11. LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders

  12. LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues

  13. LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin disorganization may lead to such functional abnormalities.

  14. Loxl1(-/-) males bred with control females demonstrated relative fecundity values intermediate between Loxl1(-/-) pairs (lowest fecundity) and control pairs (highest fecundity), suggesting a component of male-factor infertility.

LOXL1 profil antigène

Profil protéine

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Gene names and symbols associated with LOXL1

  • lysyl oxidase like 1 (LOXL1) anticorps
  • lysyl oxidase like 1 (loxl1) anticorps
  • lysyl oxidase-like 1 (Loxl1) anticorps
  • lysyl oxidase-like 1 (loxl1) anticorps
  • lysyl oxidase like 1 L homeolog (loxl1.L) anticorps
  • lol anticorps
  • loxl anticorps
  • loxl-1 anticorps
  • oxl-1 anticorps
  • si:ch211-238c15.1 anticorps

Protein level used designations for LOXL1

lysyl oxidase-like 1 , lysyl oxidase homolog 1-like , lysyl oxidase homolog 1 , lysyl oxidase-like protein 1 , lysyl oxidase 2

426411 Gallus gallus
706464 Macaca mulatta
100051862 Equus caballus
100124878 Xenopus (Silurana) tropicalis
100388123 Callithrix jacchus
100606325 Nomascus leucogenys
4016 Homo sapiens
281903 Bos taurus
16949 Mus musculus
315714 Rattus norvegicus
560115 Danio rerio
496210 Xenopus laevis
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