anti-MDS1 and EVI1 Complex Locus (MECOM) Anticorps

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. De plus, nous expédions MDS1 and EVI1 Complex Locus Protéines (9) et MDS1 and EVI1 Complex Locus Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
MECOM 294924  
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Top anti-MDS1 and EVI1 Complex Locus Anticorps sur anticorps-enligne.fr

Showing 10 out of 125 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Host: Rabbit Target Name: EVI1 Sample Tissue: Human 293T Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: MECOM Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human brain 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-MDS1 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  Raji cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$229.00
Détails
Humain Chèvre Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 6 to 7 Days
$429.84
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, IHC, WB 100 μL Connectez-vous pour afficher Disponible
$181.73
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 11 to 14 Days
$493.17
Détails
Chien Chèvre Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 11 to 14 Days
$610.50
Détails

anti-MDS1 and EVI1 Complex Locus Anticorps mieux référencés

  1. Human Polyclonal MECOM Primary Antibody pour ELISA, WB - ABIN4270672 : Konrad, Karger, Hackl, Schwarzinger, Herbacek, Wieser: Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. dans Journal of leukocyte biology 2009 (PubMed)

Plus d’anticorps contre MDS1 and EVI1 Complex Locus partenaires d’interaction

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. report on the first familial germline mutation in MDS1 and EVI1 complex locus (MECOM); finding extends MECOM germline mutation associated phenotypes and proposes MECOM as a novel HMMS candidate gene.

  2. Expression of ecotopic viral integration site 1 (EVI1) is positively correlated with talin1 (TLN1) in both chronic myeloid leukemia (CML)-chronic phase (CP) and CML-blast crisis (BC) cases.

  3. EVI1 expression is associated with aggressive behavior in intrahepatic cholangiocarcinoma.

  4. We propose the term MECOM-associated syndrome for this heterogeneous hereditary disease and inclusion of MECOM sequencing in the diagnostic workup of congenital bone marrow failure.

  5. Overall, we show the importance of performing detailed molecular cytogenetic analysis of MECOM to enable appropriate management of high-risk pediatric myeloid neoplasms.

  6. presence of 3q26.2/EVI1 rearrangements in MDS/MPN is associated with rapid disease progression, poor response to treatment, and a poor prognosis

  7. High EVI1 expression predicts poor outcome in Acute myeloid leukemia with intermediate cytogenetic risk in patients receiving chemotherapy.

  8. The relationship between EVI1 and microRNAs in human malignancies. [review]

  9. Fisher's exact SubID was used to reveal EVI1 as a transcriptional regulator of INPP4B in AML; a finding which was validated in vitro. Next, we used CoxPH SubID to conduct a pan-cancer analysis of INPP4B's prognostic significance

  10. Letter/Case Report: ETV6/MECOM gene fusion in therapy-related acute myeloid leukemia with t(3;12) and monosomy 7.

  11. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  12. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  13. The expression of EVI1 and SOX9 is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR targeting failure

  14. EVI1 contributes to PCa progression by regulating different oncogenic functions. EVI1 regulates the PCa stem cell compartment responsible for disease initiation and also development of CRPC.

  15. oncogenic potential for EVI1 in modulating genomic stability

  16. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  17. EVI1 overexpression alters cellular metabolism. EVI1 promotes CKMT1 expression by repressing the myeloid differentiation regulator RUNX1.

  18. EVI1 transcription is directly regulated by LEF1/beta-catenin complex in myeloid blast crisis of chronic myeloid leukemia. Loss of p53 function as a key regulator for beta-catenin-EVI1 in myeloid blast crisis of chronic myeloid leukemia.

  19. we demonstrated that miR-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1) mRNA is a direct target of miR-22 and MECOM (EVI1) functions as a negative regulator in the differentiation.The miR-22-mediated MECOM degradation increased c-Jun but decreased GATA2 expression, which results in increased interaction between c-Jun and PU.1

  20. Results establish the oncogenic contributions of EVI1 in ER- and HER2-negative subsets of breast cancer.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription.

  2. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  3. Gata2 heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  4. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  5. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa from EVI1-induced suppression.

  6. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF, acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF levels.

  7. Survivin partially regulates HSC function by modulating the Evi-1 transcription factor and its downstream targets

  8. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  9. Prdm16 and Prdm3 control postnatal BAT identity and function.

  10. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  11. Lack of ME leads to a complex defect in both osseous and non-osseous musculoskeletal tissues.

  12. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL) fusion protein (MFP) leukemia

  13. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta, liver inhibitory protein (LIP), induced acute myeloid leukemia with short latencies in a mouse bone marow transplantation model.

  14. Transient Evi1 transfection inhibited TGF-beta-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta in MC-26 mouse colon cancer cells.

  15. Evi1 is a key regulator of adipogenic competency

  16. Data identify Prdm3 and Prdm16 as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin.

  17. EVI1 is a critical player in tumor growth in a subset of MLL-rearranged acute myeloid leukemia.

  18. our study provides important insights into the novel role for EVI1 in negatively regulating NF-kappaB-dependent inflammation

  19. the results indicate that Evi-1 is expressed in a stage-specific manner during ovarian follicular development and may be involved in early follicle development.

  20. Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity.

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch signaling

  2. Prdm3 and prdm16 are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Xenopus laevis MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck

MDS1 and EVI1 Complex Locus (MECOM) profil antigène

Profil protéine

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (MECOM) anticorps
  • MDS1 and EVI1 complex locus (Mecom) anticorps
  • MDS1 and EVI1 complex locus (mecom) anticorps
  • MDS1 and EVI1 complex locus L homeolog (mecom.L) anticorps
  • AML1-EVI-1 anticorps
  • D630039M04Rik anticorps
  • evi-1 anticorps
  • evi1 anticorps
  • im:7140716 anticorps
  • Jbo anticorps
  • Mds anticorps
  • Mds1 anticorps
  • Mds1-Evi1 anticorps
  • mecom anticorps
  • mecom-a anticorps
  • mecom-b anticorps
  • prdm3 anticorps
  • xEvi-1 anticorps
  • Znfpr1b1 anticorps

Protein level used designations for MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID SPECIES
2122 Homo sapiens
424997 Gallus gallus
532209 Bos taurus
14013 Mus musculus
497407 Danio rerio
460837 Pan troglodytes
488148 Canis lupus familiaris
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
294924 Rattus norvegicus
734157 Xenopus laevis
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