MKL/myocardin-Like 2 Protéines (MKL2)

Acts as a transcriptional coactivator of serum response factor (SRF). De plus, nous expédions MKL2 Anticorps (36) et MKL2 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MKL2 57496 Q9ULH7
Rat MKL2 MKL2 100362470  
MKL2 239719 P59759
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days

MKL2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
Mouse (Murine)

Plus protéines pour MKL/myocardin-Like 2 (MKL2) partenaires d'interaction

Human MKL/myocardin-Like 2 (MKL2) interaction partners

  1. Taken together, these findings suggest that MKL1 and MKL2 are present at synapses and involved in dendritic spine maturation.

  2. Study showed that MRTF-A and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer.

  3. While disruption of the MKL2:SRF axis has been associated with severe microcephaly and disordered brain development in multiple model systems, the role of this transcription factor complex has not been previously demonstrated in human brain development.

  4. There were multiple independent HIV integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells.

  5. MKL1/2 depletion resulted in Ras activation, elevated p16 expression and hypophosphorylation of the retinoblastoma (Rb) protein in DLC1-deficient hepatocellular carcinoma cells.

  6. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas.

  7. study provides evidence that MKL1/2 mediates cancerous transformation in DLC1-deficient hepatocellular and mammary carcinoma cells

  8. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma.

  9. dominant negative MKL2 blocked differentiation-induced expression of SRF target genes skeletal alpha-actin and alpha-myosin heavy chain and blocked differentiation of the myoblasts to myotubes in vitro.

  10. BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases.

  11. Myocardin-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[

  12. RNA interference was used to investigate the contribution of the MRTF-SRF pathway to cytoskeletal dynamics in MDA-MB-231 breast carcinoma and B16F2 melanoma cells, in which basal MRTF-SRF activity is Rho-dependent.

Mouse (Murine) MKL/myocardin-Like 2 (MKL2) interaction partners

  1. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  2. MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 and interactions between HAoECs and leukocytes

  3. Either MRTF-A or MRTF-B is dispensable for cardiac development, whereas deletion of both causes a spectrum of abnormalities ranging from reduced cardiac contractility and adult onset heart failure to neonatal lethality accompanied by sarcomere disarray.

  4. These results identify SRF and its MRTF cofactors as major transcriptional regulators of endothelial cell junctional stability, guaranteeing physiological functions of the cerebral microvasculature.

  5. Suggest role for nuclear RhoA signaling in MRTF-dependent gene expression in smooth muscle cells.

  6. Myocardin-related transcription factor (MRTF)-A and MRTF-B (MKL1 and MKL2, respectively) are enriched in the perinuclear space of epicardial cells during development.

  7. MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.

  8. Smad2 interaction with MRTFB seems to be a novel and important mechanism underlying neural crest cell differentiation to vascular smooth muscle cells.

  9. MRTF-B knockdown leads to increase in S and G2/M populations and downregulation of cyclin-CDK inhibitors p27Kip1, p18Ink4c and 19Ink4d as well as upregulation of p21Waf1 and cyclin D1.

  10. Data suggest that MKL1 and MKL2 are expressed in megakaryocytes and platelets; megakaryocytes lacking expression of MKL1 and/or MKL2 have both defective megakaryocytopoiesis and thrombopoiesis.

  11. MKL2 regulates a conserved TGF-beta signaling pathway that is required for angiogenesis and ultimately embryonic survival.

  12. show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B and the signaling factor Fgf10

  13. MRTF-A/B are potent repressors of cancer progression and metastasis and may be good targets for cancer therapy.

  14. MRTF-B plays a critical role in regulating differentiation of cardiac neural crest cells into smooth muscle.

  15. interacts with serum response factor and stimulates its transcriptional activity

  16. Data show that mice homozygous for a myocardin-related transcription factor-B loss-of-function mutation die during mid-gestation from a spectrum of cardiovascular defects.

  17. MRTF-B has a unique role in regulating smooth muscle genes important for liver, yolk sac, and portal vascular development.

  18. This review focuses on the role MRTF-B plays in regulating cardiovascular patterning, vascular smooth muscle cell and cardiomyocyte differentiation, and in the pathogenesis of congenital heart disease and vascular proliferative syndromes.

  19. These results indicate that MRTF-A/B act as pivotal mediators of stress fiber and focal adhesion formation via the transcriptional regulation of a subset of cytoskeletal/focal adhesion genes.

Profil protéine MKL2

Profil protéine

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.

Gene names and symbols associated with MKL/myocardin-Like 2 Protéines (MKL2)

  • MKL1/myocardin like 2 (MKL2)
  • MKL1/myocardin like 2 S homeolog (mkl2.S)
  • MKL1/myocardin like 2 (mkl2)
  • MKL1/myocardin like 2 (Mkl2)
  • MKL/myocardin-like 2 (Mkl2)
  • ENSMUSG00000075401 Protéine
  • Gt4-1 Protéine
  • MGC145857 Protéine
  • mKIAA1243 Protéine
  • MRTF-B Protéine
  • mrtf-b-A Protéine
  • Mrtfb Protéine
  • npd001 Protéine

Protein level used designations for MKL/myocardin-Like 2 Protéines (MKL2)

MKL/myocardin-like protein 2 , megakaryoblastic leukemia 2 , myocardin-related transcription factor B , MRTF-B , xMRTF-B , MKL/myocardin-like 2 , megakaryoblastic leukemia 2 protein , gene trap insertion site 4-1

57496 Homo sapiens
378496 Xenopus laevis
780107 Xenopus (Silurana) tropicalis
100050736 Equus caballus
100073360 Ornithorhynchus anatinus
100350900 Oryctolagus cuniculus
100362470 Rattus norvegicus
239719 Mus musculus
100731881 Cavia porcellus
511461 Bos taurus
416421 Gallus gallus
489999 Canis lupus familiaris
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