MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) Protéines (MOBKL1B)

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. De plus, nous expédions MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) Anticorps (56) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MOBKL1B 55233 Q9H8S9
MOBKL1B 232157 Q921Y0
MOBKL1B 297387 Q3T1J9
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Top MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) Protéines sur anticorps-enligne.fr

Showing 10 out of 13 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Humain His tag   50 μg Connectez-vous pour afficher 4 Days
$522.50
Détails
Escherichia coli (E. coli) Humain His-SUMO Tag 100 μg Connectez-vous pour afficher 11 Days
$411.40
Détails
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 10 μg Connectez-vous pour afficher 8 to 11 Days
$504.90
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,531.83
Détails
Escherichia coli (E. coli) Humain His tag   10 μg Connectez-vous pour afficher 15 to 16 Days
$300.00
Détails
Levure Humain Inconjugué   100 μg Connectez-vous pour afficher 11 to 16 Days
$341.12
Détails

MOBKL1B Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) (MOBKL1B) partenaires d'interaction

Xenopus laevis MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) (MOBKL1B) interaction partners

  1. Data report the solution structure of the Mob1 protein from Xenopus laevis solved by heteronuclear multidimensional NMR.

Zebrafish MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) (MOBKL1B) interaction partners

  1. mats1 plays a critical role in regulating cell proliferation and apoptosis during early development in zebrafish[mats1]

Human MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) (MOBKL1B) interaction partners

  1. validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 (Montrer PTPN5 Protéines) and Mob1a.

  2. Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A regulates its interaction with both MST (Montrer MAP3K10 Protéines) kinases and LATS/NDR (Montrer STK38 Protéines) family kinases in vitro.

  3. In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases.

  4. MOB1 (Montrer MOBKL3 Protéines) binds differently to the NDR2 (Montrer STK38L Protéines) and LATS1 kinases.MOB1 interaction with Hippo and MST (Montrer MAP3K10 Protéines) protein is not essential for development and tissue growth control.

  5. No relationship has been found between the MOBKL1B-NS5A interaction and hepatitis C virus replication.

  6. The RING ligase praja2 ubiquitylates and degrades Mob, a core component of NDR/LATS kinase and a positive regulator of the tumour-suppressor Hippo cascade.

  7. Mob1A and Mob1B (Montrer MOB1B Protéines) are needed for cell abscission and centriole re-joining after telophase and cytokinesis.

  8. Results suggest that Mob1 (Montrer MOBKL3 Protéines) and the other mammalian orthologues of the mitotic exit network regulate mitotic progression by facilitating the timely mobilization of the chromosomal passenger complex to the spindle midzone.

  9. hMOB1A and hMOB1B are 2 LATS-binding proteins that may function as tumor suppressors in human cancer cells.

  10. Mats1 can rescue the lethality associated with loss of Mats function in Drosophila; As Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans

Mouse (Murine) MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) (MOBKL1B) interaction partners

  1. MOB1A and MOB1B (Montrer MOB1B Protéines) have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway.

Profil protéine MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) (MOBKL1B)

Profil protéine

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).

Gene names and symbols associated with MOBKL1B

  • MOB kinase activator 1A L homeolog (mob1a.L)
  • MOB kinase activator 1A (MOB1A)
  • MOB kinase activator 1A (mob1a)
  • MOB kinase activator 1A pseudogene (LOC712156)
  • MOB kinase activator 1A (Mob1a)
  • 4022402H07Rik Protéine
  • C2orf6 Protéine
  • MATS1 Protéine
  • MOB1 Protéine
  • MOB1A Protéine
  • MOB4B Protéine
  • Mobk1b Protéine
  • Mobkl1b Protéine
  • wu:fv69d04 Protéine
  • zgc:56189 Protéine

Protein level used designations for MOBKL1B

MOB1, Mps One Binder kinase activator-like 1B , Mob4B protein , mps one binder kinase activator-like 1B , MOB1, Mps One Binder kinase activator-like 1B (yeast) , mats1 , mobk1b , Mps one binder kinase activator-like 1B , mob1 homolog 1B , MOB1 Mps One Binder homolog A , mob1 alpha

GENE ID SPECIES
398675 Xenopus laevis
459544 Pan troglodytes
549780 Xenopus (Silurana) tropicalis
612924 Canis lupus familiaris
614611 Bos taurus
712156 Macaca mulatta
100005014 Danio rerio
100172677 Pongo abelii
55233 Homo sapiens
232157 Mus musculus
297387 Rattus norvegicus
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