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these data provide the evidence that membrane-bound and secretory isoforms of perforin (Montrer PRF1 Kits ELISA)-2 are present in human macrophages and may play important roles in immune defense
Collectively, these studies further underscore the biological significance of Perforin (Montrer PRF1 Kits ELISA)-2 and elucidate critical molecular events that culminate in Perforin (Montrer PRF1 Kits ELISA)-2-dependent killing of both intracellular and extracellular, cell-adherent bacteria.
the impact of Perforin (Montrer PRF1 Kits ELISA)-2/macrophage-expressed protein 1 from the earliest multicellular organisms to modern vertebrates, as well as review the development of other membrane attack complexes of complement and Perforin (Montrer PRF1 Kits ELISA) domain member proteins
Knockdown of perforin (Montrer PRF1 Kits ELISA)-2 in macrophages did not alter the invasion of host cells but did result in chlamydial growth that closely mirrored that detected in HeLa cells.
mpeg1-driven transgenes are expressed in macrophage-lineage cells that do not express neutrophil-marking transgenes.
These findings suggest that the protective role of Perforin (Montrer PRF1 Kits ELISA)-2(encoded by the macrophage-expressed gene 1, Mpeg1) against listeriosis is based on it limiting the intracellular replication of the pathogen.
this study shows that primary embryonic and established fibroblasts can be induced by interferons or by intracellular bacterial infection to express a perforin (Montrer PRF1 Kits ELISA)-like mRNA previously described as macrophage-expressed gene 1 (Mpeg1).
may be involved in the pathogenesis of disease related renal injury
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, macrophage-expressed gene 1 protein