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The protein encoded by MST1 contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. De plus, nous expédions et MST1 Protéines (15) et beaucoup plus de produits pour cette protéine.
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Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1/2)/YAP (Montrer YAP1 Kits ELISA) signaling, and that inhibition of miR (Montrer MLXIP Kits ELISA)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (Montrer SOX2 Kits ELISA) and SALL4 (Montrer SALL4 Kits ELISA).
These data suggest that MSP (Montrer MSMB Kits ELISA) is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP (Montrer MSMB Kits ELISA) has a key regulatory role in non-alcoholic steatohepatitis.
Study found that MST1 is strongly activated in a diabetic beta cell and induces not only its death but also directly impairs insulin (Montrer INS Kits ELISA) secretion through promoting proteasomal degradation of key beta cell transcription factor, pancreatic and duodenal homeobox 1 (PDX1 (Montrer PDX1 Kits ELISA)), which is critical for insulin (Montrer INS Kits ELISA) production.
deacetylation of MST1 mediated by HBXIP-enhanced HDAC6 results in MST1 degradation in a chaperone-mediated autophagy (CMA) manner in promotion of breast cancer growth.
TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
Data suggest that Hippo (MST1/2 protein kinases) - Yes associated protein 1 (YAP (Montrer YAP1 Kits ELISA)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
our results identified that mammalian sterile 20-like kinase 1 (Montrer STK4 Kits ELISA) is a novel downstream target of pyruvate kinase M2, and knockdown of pyruvate kinase M2 contributes apoptosis via promoting nuclear translocation of mammalian sterile 20-like kinase 1 (Montrer STK4 Kits ELISA) by enhancing Caspase-3 (Montrer CASP3 Kits ELISA)-dependent cleavage.
H-ras, via an Erk-dependent mechanism, downregulates Mst1/Mst2 activity by inducing the formation of inactive Mst1/Mst2 heterodimers.
Mst1 as a novel physiological negative regulator of IRF3 (Montrer IRF3 Kits ELISA) activation provides mechanistic insights into innate antiviral defense and potential antiviral prevention strategies.
Mst1 increases the (Montrer FOXP3 Kits ELISA)acetylation of Foxp3 by inhibiting Sirt1 activity, which requires the Mst1 kinase activity.
These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis.
kinases, including Slk (Montrer SLK Kits ELISA), Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
Nicorandil alleviates post-MI cardiac dysfunction and remodeling. The mechanisms were associated with enhancing autophagy and inhibiting apoptosis through Mst1 inhibition.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (Montrer YAP1 Kits ELISA) target genes and hepatocyte proliferation.
The MST1 acts as a molecular brake to maintain immune tolerance by regulating T cell-mediated B cell activation (Montrer BLNK Kits ELISA).
Mst1 knockout alleviated while Mst1 overexpression aggravated cardiac dysfunction in diabetes.
these findings highlight a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional mechanistic explanation for the severe immune defect
Results identify L-plastin as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein critical to T cell migration.
MIST1 is a scaling factor necessary and sufficient by itself to induce and maintain secretory cell architecture
Mst1 deficiency diminishes atherosclerosis and stabilizes atherosclerotic plaques in ApoE (Montrer APOE Kits ELISA)(-/-) mice. Mst1 may participate in atherosclerosis progression through inhibition of macrophage autophagy and promotion of macrophage apoptosis.
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, hepatocyte growth factor-like protein
, hepatocyte growth factor-like protein homolog
, macrophage-stimulating protein
, E2F transcription factor 2
, macrophage stimulatory protein
, hepatocyte growth factor-like/macrophage stimulating protein
, macrophage stimulating 1 (hepatocyte growth factor-like)
, 12S E1A
, macrophage stimulating 1 L homeolog