Major Facilitator Superfamily Domain Containing 2A Protéines (MFSD2A)

Plays a role in thermogenesis via beta-adrenergic signaling pathway. De plus, nous expédions MFSD2A Anticorps (36) et MFSD2A Kits (12) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MFSD2A 84879 Q8NA29
MFSD2A 76574 Q9DA75
Rat MFSD2A MFSD2A 298504  
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,626.01
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails

MFSD2A Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Major Facilitator Superfamily Domain Containing 2A (MFSD2A) partenaires d'interaction

Human Major Facilitator Superfamily Domain Containing 2A (MFSD2A) interaction partners

  1. In offspring of women with gestational diabetes mellitus treated either with diet or insulin (Montrer INS Protéines), higher fetal fat accretion and lower placental MFSD2a contribute to reduce docosahexaenoic acid availability.

  2. Levels of DHA-derived epoxides are lower in colon tissues from patients with ulcerative colitis than healthy and resolving mucosa. Production of these metabolites by gut endothelium requires MFSD2A; endothelial progenitor cells that overexpress MFSD2A reduce colitis in mice.

  3. The regulatory role of Mfsd2a deepens our knowledge of the function of the BBB, potentially contributing to the effective drug delivery in the treatments for neurodegenerative diseases, brain tumors, and life-threatening infections in the CNS

  4. MFSD2A transported structurally related acylcarnitines but not a lysolipid without a negative charge, demonstrating the necessity of a negatively charged headgroup interaction with Lys (Montrer LYZ Protéines)-436 for transport.

  5. A homozygous mutation affecting a highly conserved MFSD2A residue (p.Ser339Leu) is associated with a progressive microcephaly syndrome characterized by intellectual disability, spasticity and absent speech.

  6. MFSD2A mutations impair brain lipid transport activity.

  7. Several tagging SNPs and haplotypes in TRIT1 (Montrer TRIT1 Protéines), MYCL1 and MFSD2A region are significantly associated with risk and clinicopathological features of gastric cancer in a Chinese population.

  8. Importance of MFSD2a in trophoblast fusion and placenta development.

  9. SNP rs12072037 modulates MFSD2A promoter activity and thus might affect MFSD2A levels in normal lung and in lung tumors.

  10. MFSD2A is a putative Tunicamycin transporter at the plasma membrane.

Mouse (Murine) Major Facilitator Superfamily Domain Containing 2A (MFSD2A) interaction partners

  1. Mfsd2a may protect against BBB injury by inhibiting vesicular transcytosis following intracerebral hemorrhage.

  2. Transplantation of endothelial progenitor cells that overexpress MFSD2A reduce colitis in mice.

  3. Maternal DHA supplementation had a strong impact on offspring hepatic gene expression, especially of the fatty acid transporter, Mfsd2a, suggesting a dynamic interplay between DHA synthesis and DHA uptake in the control of systemic levels in the offspring

  4. Mfsd2a lipid transport function is required for suppression of transcytosis and blood brain barrier integrity.

  5. These findings identify LPC (Montrer PCSK7 Protéines) transport via Mfsd2a as an important pathway for DHA uptake in eye and for development of photoreceptor membrane discs.

  6. findings identify Mfsd2a as a key regulator of blood brain barrier function that may act by suppressing transcytosis in CNS endothelial cells.

  7. identification of a member of the major facilitator superfamily--Mfsd2a (previously an orphan transporter)--as the major transporter for docosahexaenoic acid uptake into brain

  8. Data suggest that the ligand(s) that are transported by MFSD2A play important roles in these physiological processes and await future identification.

  9. Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis.

Profil protéine MFSD2A

Profil protéine

Plays a role in thermogenesis via beta-adrenergic signaling pathway. May be the main plasma membrane tunicamycin transporter.

Gene names and symbols associated with MFSD2A

  • major facilitator superfamily domain containing 2A (MFSD2A)
  • major facilitator superfamily domain containing 2A (mfsd2a)
  • major facilitator superfamily domain containing 2A (Mfsd2a)
  • 1700018O18Rik Protéine
  • Mfsd2 Protéine
  • RGD1310174 Protéine

Protein level used designations for MFSD2A

major facilitator superfamily domain containing 2 , major facilitator superfamily domain containing 2A , major facilitator superfamily domain-containing protein 2A

GENE ID SPECIES
100068365 Equus caballus
718876 Macaca mulatta
100025155 Monodelphis domestica
100441975 Pongo abelii
100476592 Ailuropoda melanoleuca
100565013 Anolis carolinensis
419679 Gallus gallus
84879 Homo sapiens
475318 Canis lupus familiaris
100518612 Sus scrofa
512633 Bos taurus
76574 Mus musculus
298504 Rattus norvegicus
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