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The protein encoded by MCTS1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. De plus, nous expédions Malignant T Cell Amplified Sequence 1 Protéines (10) et Malignant T Cell Amplified Sequence 1 Kits (9) et beaucoup plus de produits pour cette protéine.
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Mouse (Murine) Polyclonal MCTS1 Primary Antibody pour IHC - ABIN966547
Carpenter, Poole, Halestrap: Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. dans Biochimica et biophysica acta 1996
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Human Polyclonal MCTS1 Primary Antibody pour WB - ABIN4891880
Haas, Ngo, Li, Schleich, Qu, Vanyai, Cullen, Cardona-Alberich, Gladwyn-Ng, Pagnamenta, Taylor, Stewart, Kini, Duncan, Teleman, Keays, Heng: De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation. dans Cell reports 2016
Human Polyclonal MCTS1 Primary Antibody pour WB - ABIN152954
Kumar, Kant, Singh et al.: Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage ... dans Toxicology and applied pharmacology 2013
Hypoxia-induced MCT1 (Montrer CMA1 Anticorps) supports glioblastoma glycolytic phenotype, being responsible for lactate efflux and an important mediator of cell survival and aggressiveness
our finding that the expression of MCT1 (Montrer CMA1 Anticorps) and MCT4 (Montrer SLC16A4 Anticorps) is reduced in mutant IDH1 (Montrer IDH1 Anticorps) gliomas highlights the unusual metabolic reprogramming that occurs in mutant IDH1 (Montrer IDH1 Anticorps) tumors and has important implications for our understanding of these tumors and their treatment
DENR (Montrer DENR Anticorps) binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1 (Montrer EIF1 Anticorps)/eIF2 (Montrer EIF2S1 Anticorps)/eIF3 (Montrer EIF3A Anticorps) binding, thus operating in post-termination ribosome recycling and translation re-initiation
MCT1 (Montrer CMA1 Anticorps) expression, independent of transporter activity, is required for growth factor-induced tumor cell motility.
TOMM20 (Montrer TOMM20 Anticorps), MCT1 (Montrer CMA1 Anticorps), and MCT4 (Montrer SLC16A4 Anticorps) expression was significantly different in Hodgkin and Reed Sternberg (HRS) cells. HRS have high expression of MCT1 (Montrer CMA1 Anticorps), while tumor associated macrophages have absent MCT1 (Montrer CMA1 Anticorps) expression. Tumor-infiltrating lymphocytes have absent MCT1 (Montrer CMA1 Anticorps) expression. Reactive lymph nodes in contrast to cHL (Montrer CHRDL1 Anticorps) tumors had low TOMM20 (Montrer TOMM20 Anticorps), MCT1 (Montrer CMA1 Anticorps), and MCT4 (Montrer SLC16A4 Anticorps) expression in lymphocytes and macrophages.
TOMM20 (Montrer TOMM20 Anticorps) and MCT1 (Montrer CMA1 Anticorps) were highly expressed in diffuse large B-cell lymphoma lymphocytes, indicating an OXPHOS phenotype, whereas non-neoplastic lymphocytes in the control samples did not express these markers.
MCT1 (Montrer CMA1 Anticorps) inhibitor AZD3965 increased MCT4 (Montrer SLC16A4 Anticorps)-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux.
Silencing or genetic deletion of MCT1 (Montrer CMA1 Anticorps) in vivo inhibited migration, invasion, and spontaneous metastasis.
The reversible H(+)/lactate(-) symporter MCT1 (Montrer CMA1 Anticorps) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.
Reinitiation complexes involving initiation factors eIF2D (Montrer EIF2D Anticorps), MCT-1 (Montrer CMA1 Anticorps), and DENR (Montrer DENR Anticorps) controls the translation of a large fraction of mammalian cellular mRNAs.
This study confirmed age-dependent changes of MCT1 expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.
These findings show that MCT 1 increases with the development of rumen function and also in adult animals MCT 1 may change with the feeding.
The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.
The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.
Data suggest that expression of MCT1 in intestinal mucosa can be altered by diet; here, expression of MCT1 is down-regulated in colonic mucosa by high-protein diet and appears to be linked to fermentation of dietary proteins by intestinal microbes.
MCT1-mRNA showed a higher expression in the ileum; feeding inulin-coated butyrate resulted in an increased ileal surface; delivery of butyrate to the colon requires a more resistant inulin-coating.
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.
malignant T cell-amplified sequence 1
, malignant T-cell-amplified sequence 1
, multiple copies T-cell malignancies
, multiple copies T-cell malignancies 1
, malignant T cell amplified sequence 1
, Malignant T cell amplified sequence 1-A
, malignant T cell-amplified sequence 1-A
, malignant T-cell-amplified sequence 1-A