Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase Protéines (MGAT1)

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. De plus, nous expédions Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase Anticorps (100) et Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase Kits (13) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MGAT1 4245 P26572
MGAT1 17308 P27808
Rat MGAT1 MGAT1 81519 Q09325
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Showing 5 out of 8 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
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Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
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Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$230.67
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Levure Arabidopsis thaliana His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,243.17
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Levure Lapin His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,254.17
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MGAT1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
, ,
Mouse (Murine)
,

Plus protéines pour Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) partenaires d'interaction

Human Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) interaction partners

  1. In this study we showed that the activation of Wnt/beta-catenin pathway culminates in the upregulation of MGAT1 enzyme both at transcriptional and post-transcriptional levels. We also showed that overexpression of the beta-catenin gene (CTNNB1) increased the promoter activity of MGAT1.

  2. The presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population.

  3. MGAT1 is downregulated in peripheral blood mononuclear cells of galactosaemia patients.

  4. The authors show here that the luminal domain of GnT1IP-L contains its MGAT1 inhibitory activity.

  5. UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).

  6. The IL2RA and IL7RA variants had univariate association in MS and T1D, whereas the MGAT1 and CTLA-4 variants associated with only MS or T1D, respectively.

  7. analysis of suppression of cancer progression by MGAT1 shRNA knockdown

  8. Genetic variants downstream MGAT1 seem to influence susceptibility to obesity. Moreover, these genetic variants affect the levels of serum unsaturated fatty acids and Delta desaturase indices, variables previously shown to correlate with obesity.

  9. Activity of HuGnTI in plants is limited by a combination of reduced protein stability, alternative protein targeting and possibly to some extend to lower enzymatic performance of the catalytic domain in the plant biochemical environment.

  10. The analysis enabled us to identify a new candidate gene, MGAT1, associated with weight in women.

  11. Findings indicated that cysteine 121 has a structural role in maintaining active site geometry of hGnT1, rather than a catalytic role, and illustrates for the first time the potential utility of E. coli as an expression system for hGnT1.

Mouse (Murine) Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) interaction partners

  1. MGAT1 is required to regulate ERK1/2 signaling during spermatogenesis, potentially via different mechanisms.

  2. The MGAT1 interacts with DGAT2, which serves to synergistically increase the TAG biosynthesis and LD expansion, leading to enhancement of lipid accumulation in the liver and fat.

  3. this study shows that loss of O-GlcNAc transferase blocks T cell progenitor renewal, malignant transformation and peripheral T cell clonal expansion

  4. Inhibition of hepatic Mogat1 improves hepatic metabolic abnormalities without attenuating liver inflammation and injury.

  5. Data from transgenic mice suggest that a lack of complex N- and O-glycans impairs early embryo development and viability in vivo leading to delayed implantation and embryo loss; Mgat1 and C1galt1 are required for embryo development and implantation.

  6. analysis of suppression of cancer progression by MGAT1 shRNA knockdown

  7. the MGAT1 pathway induced by hepatic PPARgamma is critically important in the development of hepatic steatosis during diet-induced obesity

  8. essential for spermatogenesis

  9. Mgat1 mutant oocytes had an altered zona pellucida (ZP) that was thinner than the control ZP, and they did not possess complex N-glycans

  10. analysis of developmental and nutritional regulation of monoacylglycerol lipase and monoacylglycerol acyltransferase

Fruit Fly (Drosophila melanogaster) Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) interaction partners

  1. MGAT1-dependent N-glycosylation shapes the synaptomatrix carbohydrate environment and endogenous lectin localization within this domain, to modulate retention of trans-synaptic signaling ligands driving synaptic scaffold recruitment during synaptogenesis.

  2. show that knockdown of Mgat1 in the central nervous system (CNS) of wild-type flies decreases locomotor activity and life span.

  3. beta1,2-N-acetylglucosaminyltransferase I-dependent N-glycans are required for locomotory activity, life span, and brain development in Drosophila

Cow (Bovine) Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) interaction partners

  1. N-acetylglucosaminyltransferase I activity in the oviduct may contribute to the induction of glycosylation and thereby contributing to the provision of the optimal microenvironment for fertilization and early development of the embryos.

Arabidopsis thaliana Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1) interaction partners

  1. Activity of HuGnTI in plants is limited by a combination of reduced protein stability, alternative protein targeting and possibly to some extend to lower enzymatic performance of the catalytic domain in the plant biochemical environment.

Profil protéine Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,2-N-Acetylglucosaminyltransferase (MGAT1)

Profil protéine

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene.

Gene names and symbols associated with MGAT1

  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT1)
  • mannoside acetylglucosaminyltransferase 1 (Mgat1)
  • Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 1 (Mgat1)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase S homeolog (mgat1.S)
  • alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC410105)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (mgat1)
  • Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (mgat1)
  • alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (CGL1)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase a (mgat1a)
  • CG13431 Protéine
  • CGL Protéine
  • COMPLEX GLYCAN LESS Protéine
  • COMPLEX GLYCAN LESS 1 Protéine
  • Dmel\\CG13431 Protéine
  • dMGAT1 Protéine
  • F20D10.360 Protéine
  • F20D10_360 Protéine
  • GB16928 Protéine
  • GlcNAc-TI Protéine
  • GlcNAcT1 Protéine
  • GLCT1 Protéine
  • GLYT1 Protéine
  • GNT-1 Protéine
  • GNT-I Protéine
  • GNTI Protéine
  • MGAT Protéine
  • Mgat-1 Protéine
  • MGAT1 Protéine
  • N-ACETYLGLUCOSAMINYLTRANSFERASE I Protéine
  • zgc:66030 Protéine

Protein level used designations for MGAT1

N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I , alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase , glcNAc-T I , GNT-I , CG13431-PA , Mgat1-PA , N-acetylglucosaminyltransferase I , MGAT1 gene for N-acetylglucosaminyltransferase , mannoside acetylglucosaminyltransferase 1 , alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase , UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I , mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase , Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

GENE ID SPECIES
4245 Homo sapiens
17308 Mus musculus
37323 Drosophila melanogaster
81519 Rattus norvegicus
379038 Xenopus laevis
410105 Apis mellifera
462340 Pan troglodytes
491674 Canis lupus familiaris
496815 Xenopus (Silurana) tropicalis
534248 Bos taurus
707375 Macaca mulatta
100009521 Oryctolagus cuniculus
100172524 Pongo abelii
100196739 Salmo salar
100583691 Nomascus leucogenys
829981 Arabidopsis thaliana
393649 Danio rerio
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