Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase Protéines (MGAT3)

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. De plus, nous expédions MGAT3 Anticorps (71) et MGAT3 Kits (12) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MGAT3 17309  
MGAT3 4248 Q09327
Rat MGAT3 MGAT3 29582 Q02527
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Showing 3 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,493.38
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$340.00
Détails

MGAT3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)
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Human ,
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Plus protéines pour Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase (MGAT3) partenaires d'interaction

Mouse (Murine) Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase (MGAT3) interaction partners

  1. The MGAT3 and bisected complex N-glycans retard mouse mammary tumor progression; identification of key galectins that promote mammary tumor progression in mice is not straightforward because the galectin genes are expressed; and high levels of MGAT3.

  2. data suggest that Fut8(-/-) mice adapted to oxidative stress, both ex vivo and in vivo, by inducing various genes including GnT-III, which may compensate for the loss of core fucose functions

  3. Mgat3 glycogene expression and GnT-III-mediated glycosylation, specifically on E-cadherin, is a novel and major component of the Epithelial-Mesenchymal-Transition and the reverted process, Mesenchymal-Epithelial-Transition mechanism.

  4. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines

  5. GnT-III expression may be precisely regulated by the interplay of E-cadherin-catenin complex-mediated cell-cell adhesion and Wnt/beta-catenin signaling

  6. upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production

  7. mice homozygous for the Mgat3T37 mutation that express truncated GlcNAc-TIII from two mutant alleles suffer neurological and other consequences

  8. beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin

  9. An E-cadherin-dependent pathway plays a critical role in regulation of GnT-III expression; changes in GnT-III expression presumably contribute to intracellular signaling transduction during tissue development and homeostasis.

Human Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase (MGAT3) interaction partners

  1. Results strongly indicate that the MGAT3 and BACH2 genes play an important role in IBD pathogenesis and suggest a possible disease pathway mediated by the pro-inflammatory properties of IgG antibodies acquired by alterations in Fc glycosylation.

  2. Novel insights into the epigenetic regulation of MGAT3/bisecting GlcNAc and demonstrate the importance of N-glycosylation in cancer progression.

  3. Data suggest that GNT-III expression regulates levels/activation of the heavily glycosylated Notch receptor involved in normal and malignant cell development; suppression of GNT-III in epithelial ovarian carcinoma cell lines results in down-regulation of Notch signaling that is more potent than pharmacologic blockage of Notch activation.

  4. MGAT3 expressed in cells stimulates lipid droplet growth. These findings provide additional evidence that MGAT3 likely functions as a triacylglycerol synthase in cells.

  5. Core-fucosylated tetra-antennary structures were decreased in quantity likely as a result of hypomethylated MGAT3 gene promoter followed by increased expression of this gene

  6. High expression of alpha2,6-sialylation on the cell surface could affect the anti-migratory role of GnT-III, which provides an insight into the mechanistic roles of GnT-III in tumor metastasis.

  7. Mgat3 plays an important role in early spontaneous miscarriage in humans.

  8. MGAT3 protein and gene expression in in uveal and cutaneous melanoma cells

  9. HS5 cells had significantly enhanced levels of bisecting N-glycans (catalyzed by MGAT3 whereas HS27a cells had enhanced levels of Galbeta1,4GlcNAc.

  10. functional characterization of N-acetylglucosaminyltransferases III and V in human melanoma cells

  11. GnT-III determines E-cadherin-mediated tumor suppression, and GnT-V regulates E-cadherin-mediated tumor invasion.

  12. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines

  13. MGAT3 mRNA biomarker may characterize subgroups of Alzheimer's disease patients with different disease progression.

  14. the modulation of glycosyltransferases MGAT3 and MGAT5 by synthetic N-acetyl-D-glucosamine-calix[4]arene correlated with the improvement of NK cell effector functions and the augmentation of tumor cells sensitivity to NK cell-mediated cytotoxicity.

  15. upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production

  16. down-regulation of hydrogen peroxide-induced PKC delta activation in cells transfected with this enzyme

  17. beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin

  18. An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III.

  19. MGAT3 and MGAT5 competitively modified E-cadherin N-glycans.

Profil protéine MGAT3

Profil protéine

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with MGAT3

  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (MGAT3)
  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase a (mgat3a)
  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase L homeolog (mgat3.L)
  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (mgat3)
  • mannoside acetylglucosaminyltransferase 3 (Mgat3)
  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (Mgat3)
  • 1110038J12Rik Protéine
  • AI848272 Protéine
  • GNT-III Protéine
  • GNT3 Protéine
  • mgat3 Protéine
  • zgc:112067 Protéine

Protein level used designations for MGAT3

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase , mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase , beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like , N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III , glcNAc-T III , GlcNAc-T III , N-acetylglucosaminyltransferase III , GNT-III , mannoside acetyl glucosaminyltransferase 3

GENE ID SPECIES
418013 Gallus gallus
470218 Pan troglodytes
481244 Canis lupus familiaris
520087 Bos taurus
553676 Danio rerio
703643 Macaca mulatta
100055333 Equus caballus
100090777 Ornithorhynchus anatinus
100381104 Xenopus laevis
100401747 Callithrix jacchus
100461728 Pongo abelii
100492491 Xenopus (Silurana) tropicalis
17309 Mus musculus
4248 Homo sapiens
29582 Rattus norvegicus
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