anti-Maternal Embryonic Leucine Zipper Kinase (MELK) Anticorps

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). De plus, nous expédions MELK Kits (17) et MELK Protéines (10) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MELK 9833 Q14680
MELK 17279 Q61846
MELK 362510  
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Top anti-MELK Anticorps sur anticorps-enligne.fr

Showing 10 out of 133 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-MELK Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HT1080 cell lysate 100 μL 2 to 3 Days
$289.00
Détails
Humain Chèvre Inconjugué ELISA, WB ABIN184576 (0.1µg/ml) staining of human testes lysate (RIPA buffer, 1.4E5 cells per lane). Detected by western blot using chemiluminescence. 100 μg 6 to 7 Days
$429.84
Détails
Boeuf (Vache) Lapin Inconjugué WB Host:  Rabbit  Target Name:  Melk  Sample Type:  Mouse Testis lysates  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
$289.00
Détails
Humain Souris Inconjugué ICC, FACS, IHC, ELISA Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of MCF-7 cells using MELK mouse mAb (green) and negative control (red) . 0.1 mg 3 to 4 Days
$430.10
Détails
Humain Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of MELK staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of MELK staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
$487.50
Détails
Humain Souris Inconjugué ELISA, FACS, IF/ICC, IHC 100 μg 11 to 16 Days
$469.05
Détails
Humain Souris Inconjugué ELISA, FACS, IF, IHC 100 μg 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from K562 cells, using MELK Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Roussette (Chauve-souris) Chèvre Inconjugué ELISA, WB 100 μg 11 to 14 Days
$610.50
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails

anti-MELK Anticorps mieux référencés

  1. Human Monoclonal MELK Primary Antibody pour ICC, FACS - ABIN969538 : Nakano, Joshi, Visnyei, Hu, Watanabe, Lam, Wexler, Saigusa, Nakamura, Laks, Mischel, Viapiano, Kornblum: Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. dans Neuro-oncology 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal MELK Primary Antibody pour ELISA, WB - ABIN546704 : Lin, Park, Nishidate, Nakamura, Katagiri: Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. dans Breast cancer research : BCR 2007 (PubMed)

  3. Human Polyclonal MELK Primary Antibody pour ELISA, WB - ABIN543667 : Heyer, Warsowe, Solter, Knowles, Ackerman: New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. dans Molecular reproduction and development 1997 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal MELK Primary Antibody pour ELISA, WB - ABIN543668 : Davezac, Baldin, Blot, Ducommun, Tassan: Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. dans Oncogene 2002 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal MELK Primary Antibody pour ELISA, WB - ABIN263108 : Nagase, Seki, Ishikawa, Tanaka, Nomura: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. dans DNA research : an international journal for rapid publication of reports on genes and genomes 1996 (PubMed)

Plus d’anticorps contre MELK partenaires d’interaction

Human Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. MELK is highly expressed in cervical cancer and correlates with tumor metastasis. MELK is positively involved in cervical cancer cell proliferation, apoptosis, colony formation, and DNA damage repair. Therefore, MELK may be a novel biomarker predicting the poor prognosis of cervical cancer.

  2. Here, the authors generate several additional knockout clones of MELK and demonstrate that across cancer types, cells lacking MELK exhibit wild-type growth in vitro, under environmental stress, in the presence of cytotoxic chemotherapies, and in vivo.

  3. data suggest that MELK is a modulator of tumor cell growth and survival in a hypoxic microenvironment in adrenal cancer cells and support future investigation of its role as a therapeutic kinase target in patients with Adrenocortical Carcinoma.

  4. Study found that STRAP and MELK were overexpressed and highly phosphorylated in samples form colorectal adenocarcinoma patients and their expression were significantly correlated with tumor stages.

  5. Study demonstrates that the interaction occurring between MELK and EZH2 promotes self-proliferation and stemness.

  6. In common culture conditions, the authors found that small molecule inhibition, genetic deletion, or acute depletion of MELK did not significantly affect cellular growth.

  7. Synthesis of MCL1, an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling.

  8. Inhibition of MELK (genetically and pharmacologically) induces radiation sensitivity.

  9. MELK is a host factor required for optimal uncoating of the HIV-1 core to promote viral cDNA synthesis.

  10. Here, the authors report that mutagenizing MELK with CRISPR/Cas9 has no effect on the fitness of basal breast cancer cell lines or cell lines from six other cancer types. Cells that harbor null mutations in MELK exhibit wild-type doubling times, cytokinesis, and anchorage-independent growth.

  11. MELK-inhibitor has a role in triple-negative breast cancer cells demonstrating context-dependent response with p53 as a key determinant

  12. MELK is an oncogenic kinase involved in the pathogenesis and recurrence of hepatocellular carcinoma.

  13. Inhibition or depletion of MELK reduced cell proliferation and anchorage-dependent and -independent growth in various ovarian cancer cell lines through a G2/M cell cycle arrest, eventually resulting in apoptosis.

  14. Report IL11RA and MELK amplification in gastric cancer cell lines and primary gastric adenocarcinomas.

  15. MELK expression in hepatocellular carcinoma is extremely intense compared to its expression reported in other types of cancer and could be a promising effective tumor marker of HCC.

  16. targeting MELK by the inhibition of both its catalytic activity and its protein stability might sensitize tumours to DNA-damaging agents or radiation therapy by lowering the DNA-damage threshold

  17. Together, these data indicate that MELK is a normally non-essential kinase, but is critical for basal-like breast cancer.

  18. EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner

  19. we report characterization of possible roles of MELK in acute myeloid leukemia

  20. insight has been brought by the discovery of a protein complex of FOXM1 with the mitotic kinase MELK in cancer stem cells in brain cancers, as this protein complex appears to be cancer-specific

Mouse (Murine) Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. These findings suggest that Smad proteins have class-specific impacts on obesity-associated metabolism by differentially regulating MPK38 activity in diet-induced obese mice.

  2. MELK promotes cell migration and invasion via the FAK/Paxillin pathway, and plays an important role in the occurrence and development of gastric cancer.

  3. Phosphorylation of the activation loop of MPK38 induces its movement resulting in kinase activation.

  4. These results indicate that Trx functions as a physiological inhibitor of MPK38, which plays an important role in inducing ASK1-, TGF-beta, and p53-mediated activity

  5. an important role for MPK38-mediated phosphorylation of PDK1 in the negative regulation of PDK1 activity.

  6. MPK38 may act as a novel regulator for promoting p53 activity through direct phosphorylation of p53 at Ser(15).

  7. Upregulation of maternal embryonic leucine zipper kinase is associated with mammary tumor.

  8. MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP-expressing progenitors to rapid amplifying progenitors in the postnatal brain.

  9. The characterization of two novel E2F target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1) and maternal embryonic leucine zipper kinase (Melk) is reported.

  10. MPK38 physically interacts with ASK1 in vivo and acts as a positive upstream regulator of ASK1

Zebrafish Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. Melk-like gene may play a role in primitive hematopoiesis by affecting the expression of genes critical for hematopoiesis.

Xenopus laevis Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. Overexpression of xMELK leads to failure of cytokinesis and impairs accumulation RhoA- a pivotal regulator of cytokinesis.

  2. These results demonstrate the presence of a mitochondrial targeting signal at the N-terminus of the MC domain of MELK. This mitochondrial targeting signal was also functional in human HeLa cells.[MELK]

MELK profil antigène

Profil protéine

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis.

Gene names and symbols associated with MELK

  • maternal embryonic leucine zipper kinase (MELK) anticorps
  • maternal embryonic leucine zipper kinase (melk) anticorps
  • maternal embryonic leucine zipper kinase (cgd5_2270) anticorps
  • maternal embryonic leucine zipper kinase (Melk) anticorps
  • maternal embryonic leucine zipper kinase L homeolog (melk.L) anticorps
  • AI327312 anticorps
  • fb71b01 anticorps
  • fe01f04 anticorps
  • HPK38 anticorps
  • Melk anticorps
  • mKIAA0175 anticorps
  • MPK38 anticorps
  • wu:fb71b01 anticorps
  • wu:fe01f04 anticorps
  • xmelk anticorps

Protein level used designations for MELK

maternal embryonic leucine zipper kinase , maternal embryonic leucine zipper kinase-like , pEg3 kinase , protein kinase Eg3 , protein kinase PK38 , tyrosine-protein kinase MELK , zMelk , Protein kinase Eg3

GENE ID SPECIES
428391 Gallus gallus
465095 Pan troglodytes
549144 Xenopus (Silurana) tropicalis
3373320 Cryptosporidium parvum Iowa II
100123808 Nasonia vitripennis
100386947 Callithrix jacchus
100586707 Nomascus leucogenys
9833 Homo sapiens
481608 Canis lupus familiaris
520088 Bos taurus
17279 Mus musculus
362510 Rattus norvegicus
30724 Danio rerio
397927 Xenopus laevis
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